公开(公告)号：US11406617B2

公开(公告)日：2022-08-09

申请号：US16472084

申请日：2017-12-22

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Ralf Warrass ,  Joachim Ullrich ,  Michael Berger ,  Michael Linder

IPC: A61K31/27 ,  A61P31/04 ,  A61P11/00 ,  A61K9/00 ,  A61K31/166 ,  A61K31/222 ,  A61K31/357 ,  A61K31/40 ,  A61K31/445 ,  A61K31/472 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/695

Abstract: The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20150080365A1

公开(公告)日：2015-03-19

申请号：US14387437

申请日：2013-03-27

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Marko Eck ,  Christopher Kern

IPC: C07D487/08 ,  C07D401/04 ,  C07D277/46 ,  C07D215/38 ,  C07D271/07 ,  C07D401/12 ,  C07D239/42

CPC classification number: C07D487/08 ,  C07D213/74 ,  C07D213/82 ,  C07D213/85 ,  C07D213/89 ,  C07D215/38 ,  C07D239/42 ,  C07D271/07 ,  C07D271/113 ,  C07D277/42 ,  C07D277/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12

Abstract: This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

Abstract translation: 本发明涉及用作药物的某些杂芳基化合物，更具体地涉及用于治疗动物的药物。 药物可用于治疗蠕虫感染和治疗由蠕虫感染引起的寄生虫病。 本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。 本发明还涉及包含该化合物的药物组合物和试剂盒。

公开(公告)号：US12227485B2

公开(公告)日：2025-02-18

申请号：US17253346

申请日：2019-06-24

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Michael Berger ,  Ralf Warrass ,  Joachim Ullrich

IPC: C07D239/94 ,  A61P11/00 ,  A61P31/04 ,  C07D217/22 ,  C07D275/04

Abstract: The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US12157717B2

公开(公告)日：2024-12-03

申请号：US17253437

申请日：2019-06-24

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Michael Berger ,  Ralf Warrass ,  Joachim Ullrich

IPC: C07C259/06 ,  A61P31/04 ,  C07C333/20 ,  C07D213/36 ,  C07D277/28 ,  C07D307/52

Abstract: The present invention provides compounds of formula (I) for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20200283389A1

公开(公告)日：2020-09-10

申请号：US16063944

申请日：2016-12-22

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Hans Peter Niedermann ,  Tobias Kappesser ,  Stephan Veit ,  Heiko Bothe ,  Marcus Knell ,  Christophe Pierre Alain Chassaing

IPC: C07D213/75 ,  C07D213/74

Abstract: An improved process for producing a compound of Formula (I).

公开(公告)号：US20190135725A1

公开(公告)日：2019-05-09

申请号：US16240271

申请日：2019-01-04

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Stephan Veit ,  Hans Peter Niedermann ,  Tobias Kappesser ,  Alfred Stutz

IPC: C07C51/09 ,  C07C67/313 ,  C07C67/30 ,  C07C67/31 ,  C07C67/327 ,  C07C67/343

CPC classification number: C07C51/09 ,  C07C67/30 ,  C07C67/31 ,  C07C67/313 ,  C07C67/327 ,  C07C67/343 ,  C07C59/58 ,  C07C57/52 ,  C07C69/734 ,  C07C69/65 ,  C07C69/716 ,  C07C69/675 ,  C07C69/708

Abstract: A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

公开(公告)号：US09321724B2

公开(公告)日：2016-04-26

申请号：US14386954

申请日：2013-03-27

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Marko Eck ,  Christopher Kern

IPC: C07D207/34 ,  C07D213/74 ,  C07D215/38 ,  C07D277/42 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/435 ,  C07D213/40 ,  C07D213/85 ,  C07D217/22 ,  C07D241/20 ,  C07D249/14 ,  C07D271/07 ,  C07D277/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D471/10 ,  C07D487/04

CPC classification number: C07D213/40 ,  C07D207/34 ,  C07D213/74 ,  C07D213/85 ,  C07D215/38 ,  C07D217/22 ,  C07D241/20 ,  C07D249/14 ,  C07D271/07 ,  C07D277/42 ,  C07D277/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D471/10 ,  C07D487/04

Abstract: This invention relates to certain heteroaryl compounds which may be used as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of parasitic infections such as helminth infections and the treatment of parasitosis caused by such infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

Abstract translation: 本发明涉及可用作药物的某些杂芳基化合物，更具体地涉及用于治疗动物的药物。 药物可用于治疗诸如蠕虫感染的寄生虫感染和由这种感染引起的寄生虫病的治疗。 本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。 本发明还涉及包含该化合物的药物组合物和试剂盒。

公开(公告)号：US20230000813A1

公开(公告)日：2023-01-05

申请号：US17807984

申请日：2022-06-21

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Ralf Warrass ,  Joachim Ullrich ,  Michael Berger ,  Michael Linder

IPC: A61K31/27 ,  A61P31/04 ,  A61P11/00 ,  A61K9/00 ,  A61K31/166 ,  A61K31/222 ,  A61K31/357 ,  A61K31/40 ,  A61K31/445 ,  A61K31/472 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/695

Abstract: The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US11034650B2

公开(公告)日：2021-06-15

申请号：US16472001

申请日：2017-12-22

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Thorsten Meyer ,  Joachim Ullrich ,  Ralf Warrass

IPC: A61K31/165 ,  A61P11/00 ,  C07D259/00 ,  C07D205/04 ,  C07D207/14 ,  C07D213/56 ,  C07D217/18 ,  C07D233/64 ,  C07D267/10 ,  C07D277/28 ,  C07D295/00 ,  C07D307/56 ,  C07D333/20 ,  C07D409/12 ,  C07C259/06 ,  A61P31/04 ,  C07C317/50 ,  C07C323/60 ,  C07D235/14 ,  C07D295/155 ,  C07D307/52 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20210107874A1

公开(公告)日：2021-04-15

申请号：US16496514

申请日：2018-03-30

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Hans Peter Niedermann ,  Marcus Knell ,  Anne Lehay ,  Angelique Duval ,  Anne-Laure Morer ,  Susi Alteheld

IPC: C07D213/74 ,  A61K47/10 ,  A61K9/08 ,  A61K47/02 ,  A61K47/22 ,  A61K47/12 ,  A61K47/38 ,  A61K47/18 ,  A61K47/14 ,  A61K47/20 ,  A61K47/26

Abstract: The present invention is directed to a salt of a compound of formula (I), R1 is halogen or methyl; X is methyl, OR2, or SR2; Y1, Y2 is CR3 or N, and one of Y1, Y2 is N and one of Y1, Y2 is CR3; R2 is methyl or ethyl; R3 is hydrogen or methyl, wherein the salt is chosen from the group 10 consisting of malate salt, citrate salt, tartrate salt, oxalate salt, fumarate salt, lactate salt, glucoronate salt, oxoglucoronate salt, ethanesulfonate salt, and succinate salt. The present invention is further related to a pharmaceutical formulation comprising the salt of the invention wherein the base compound is present in an amount of 2-30% (w/v) and having a pH value of at least 3.7 and to methods of treatment using the salt of the invention.