公开(公告)号：US20200239906A1

公开(公告)日：2020-07-30

申请号：US16738015

申请日：2020-01-09

Applicant: Intrexon Corporation

Inventor： Jeremiah F. Roeth ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/85 ,  C12N15/86 ,  C07K14/54 ,  C12N15/861 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/44 ,  A61K48/00 ,  C12N5/0784

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.

公开(公告)号：US20160208285A1

公开(公告)日：2016-07-21

申请号：US14982815

申请日：2015-12-29

Applicant: Intrexon Corporation

Inventor： Jeremiah F. Roeth ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/85 ,  A61K38/20 ,  A61K48/00 ,  C12N5/0784 ,  A61K38/19

CPC classification number: C12N15/85 ,  A61K38/191 ,  A61K38/208 ,  A61K38/212 ,  A61K38/44 ,  A61K48/0066 ,  C07K14/5434 ,  C12N5/0639 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2840/203 ,  Y02A50/463

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.

公开(公告)号：US10584351B2

公开(公告)日：2020-03-10

申请号：US15648623

申请日：2017-07-13

Applicant: Intrexon Corporation

Inventor： Jeremiah F. Roeth ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/861 ,  C07K14/55 ,  A61K38/20 ,  C07K14/47 ,  C12N15/85 ,  C12N15/86 ,  C07K14/54 ,  A61K38/19 ,  A61K38/21 ,  A61K38/44 ,  A61K48/00 ,  C12N5/0784

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immuunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.