公开(公告)号：US20200239906A1

公开(公告)日：2020-07-30

申请号：US16738015

申请日：2020-01-09

Applicant: Intrexon Corporation

Inventor： Jeremiah F. Roeth ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/85 ,  C12N15/86 ,  C07K14/54 ,  C12N15/861 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/44 ,  A61K48/00 ,  C12N5/0784

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.

公开(公告)号：US20160317678A1

公开(公告)日：2016-11-03

申请号：US15151947

申请日：2016-05-11

Applicant: Intrexon Corporation

Inventor： Jeremiah F. ROETH ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler ,  Fayaz Khazi

IPC: A61K48/00 ,  C12N15/86 ,  A61K38/18 ,  C12N15/85 ,  A61K38/20 ,  A61K38/21

CPC classification number: A61K48/0025 ,  A61K38/1816 ,  A61K38/208 ,  A61K38/212 ,  A61K48/0066 ,  A61K48/0075 ,  C07K14/4713 ,  C07K14/505 ,  C07K14/5428 ,  C07K14/5434 ,  C07K14/56 ,  C07K14/565 ,  C07K14/70567 ,  C07K2319/70 ,  C07K2319/715 ,  C07K2319/81 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2750/14143 ,  C12N2830/002 ,  C12N2830/75 ,  C12N2830/85 ,  C12N2840/203

Abstract: This invention relates to the field of therapeutics. Disclosed are methods of generating conditionally expressing erythropoietin under the control of an ecdysone receptor-based gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. The methods of the invention cause an in vivo increase in the expression of erythropoietin and an increase in the hematocrit or volume percentage of red blood cells in blood after administration of the ligand.

Abstract translation: 本发明涉及治疗领域。 公开了在活化配体存在下在基于蜕皮激素受体的基因表达调节系统的控制下产生有条件表达促红细胞生成素的方法以及用于动物治疗目的的用途。 本发明的方法导致体内增加促红细胞生成素的表达，并且在给予配体后血液中红血细胞的血细胞比容或体积百分数增加。

公开(公告)号：US20160208285A1

公开(公告)日：2016-07-21

申请号：US14982815

申请日：2015-12-29

Applicant: Intrexon Corporation

Inventor： Jeremiah F. Roeth ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/85 ,  A61K38/20 ,  A61K48/00 ,  C12N5/0784 ,  A61K38/19

CPC classification number: C12N15/85 ,  A61K38/191 ,  A61K38/208 ,  A61K38/212 ,  A61K38/44 ,  A61K48/0066 ,  C07K14/5434 ,  C12N5/0639 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2840/203 ,  Y02A50/463

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.

公开(公告)号：US10584351B2

公开(公告)日：2020-03-10

申请号：US15648623

申请日：2017-07-13

Applicant: Intrexon Corporation

Inventor： Jeremiah F. Roeth ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/861 ,  C07K14/55 ,  A61K38/20 ,  C07K14/47 ,  C12N15/85 ,  C12N15/86 ,  C07K14/54 ,  A61K38/19 ,  A61K38/21 ,  A61K38/44 ,  A61K48/00 ,  C12N5/0784

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immuunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.

公开(公告)号：US20180002719A1

公开(公告)日：2018-01-04

申请号：US15648623

申请日：2017-07-13

Applicant: Intrexon Corporation

Inventor： Jeremiah F. ROETH ,  Charles C. Reed ,  Brandon Cuthbertson ,  Sunil Chada ,  William E. Fogler

IPC: C12N15/85 ,  A61K38/20 ,  A61K38/21 ,  A61K38/44 ,  C12N15/86 ,  A61K38/19 ,  C07K14/54 ,  A61K48/00 ,  C12N5/0784 ,  C12N15/861

Abstract: This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing vectors for one or more immuunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals. These vector may be provided to treat a variety of disorders, e.g., neoplastic disorders, through direct injection or through in vitro engineered cells, such as dendritic cells.