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公开(公告)号：US08410126B2
公开(公告)日：2013-04-02
申请号：US12784813
申请日：2010-05-21
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D401/12 , C07D239/48 , C07D405/12
摘要： Compounds of general formula (1) wherein A, B, R1 to R5, Rx m, n and p are defined as described in the specification, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and the use thereof [as] medicaments.
摘要翻译： 其中A，B，R1至R5，Rx m，n和p的通式（1）的化合物如本说明书所述定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，其含有 这些化合物及其用作药物。
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公开(公告)号：US20110130401A1
公开(公告)日：2011-06-02
申请号：US12784813
申请日：2010-05-21
IPC分类号： A61K31/505 , C07D401/12 , C07D239/48 , C07D403/12 , C07D413/12 , A61K31/506 , A61K31/496 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D405/12
摘要： Compounds of general formula (1) wherein A, B, R1 to R5, Rx m, n and p are defined as described in the specification, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and the use thereof [as] medicaments.
摘要翻译： 其中A，B，R1至R5，Rx m，n和p的通式（1）的化合物如本说明书所述定义，其适用于治疗特征为过度或异常细胞增殖的疾病，其含有 这些化合物及其用作药物。
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公开(公告)号：US08466155B2
公开(公告)日：2013-06-18
申请号：US12893240
申请日：2010-09-29
IPC分类号： C07D239/47 , C07D403/12 , A61K31/496
CPC分类号： C07D239/47 , C07D403/12 , C07D417/12
摘要： The present invention encompasses compounds of general formulae (1a) and (1b) wherein the groups R1 to R5, A, Q, m, n, p and q are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments.
摘要翻译： 本发明包括通式（1a）和（1b）的化合物，其中基团R 1至R 5，A，Q，m，n，p和q如权利要求1所定义，其适用于治疗以 过度或异常的细胞增殖，以及它们作为药物的用途。
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公开(公告)号：US08785464B2
公开(公告)日：2014-07-22
申请号：US14049575
申请日：2013-10-09
IPC分类号： C07D401/12 , C07D401/14 , A61K31/505
CPC分类号： C07D417/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： The present invention includes compounds of general formula (1) wherein A, X, R1 and R2 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，R 1和R 2如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，及其用于制备具有 上述属性。
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公开(公告)号：US20110288109A1
公开(公告)日：2011-11-24
申请号：US13130069
申请日：2009-11-24
IPC分类号： A61K31/506 , C07D401/14 , C07D417/14 , C07D403/12 , A61P37/06 , C07D413/14 , A61P35/00 , A61P31/00 , A61P29/00 , C07D401/12 , C07D405/14
CPC分类号： C07D417/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： The present invention includes compounds of general Formula (1), wherein A, X, R1 and R2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，R 1和R 2如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备药物 具有上述性质。
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公开(公告)号：US20110237598A1
公开(公告)日：2011-09-29
申请号：US12893240
申请日：2010-09-29
IPC分类号： A61K31/496 , C07D239/47 , A61K31/505 , C07D401/12 , A61K31/506 , C07D403/12 , A61P31/00 , A61P35/00 , A61P29/00
CPC分类号： C07D239/47 , C07D403/12 , C07D417/12
摘要： The present invention encompasses compounds of general formulae (1a) and (1b) wherein the groups R1 to R5, A, Q, m, n, p and q are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use as medicaments.
摘要翻译： 本发明包括通式（1a）和（1b）的化合物，其中基团R 1至R 5，A，Q，m，n，p和q如权利要求1所定义，其适用于治疗以 过度或异常的细胞增殖，以及它们作为药物的用途。
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7.发明申请2,4-DIAMINOPYRIMIDINE DERIVATES AS PTK2- INHIBITORS FOR THE TREATMENT OF ABNORMAL CELL GROWTH 有权2,4-二氨基嘧啶衍生物作为治疗异常细胞生长的PTK2-抑制剂公开(公告)号：US20110275633A1
公开(公告)日：2011-11-10
申请号：US13128029
申请日：2009-11-13
IPC分类号： A61K31/506 , C07D413/12 , C07D403/12 , C07D407/14 , A61P37/00 , A61K31/5377 , A61K31/496 , A61P35/00 , A61P29/00 , C07D401/12 , C07D413/14
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1-R3 and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R1-R3和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备具有上述药物的用途 提到的属性。
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公开(公告)号：US08846689B2
公开(公告)日：2014-09-30
申请号：US13130669
申请日：2009-11-24
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04
CPC分类号： C07D413/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D419/14 , C07D493/04
摘要： The present invention encompasses compounds of general formula (1) wherein A, B, X, R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，B，X，R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备 具有上述特性的药物。
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9.发明授权2,4-diaminopyrimidine derivates as PTK2-inhibitors for the treatment of abnormal cell growth 有权2,4-二氨基嘧啶衍生物作为治疗异常细胞生长的PTK2抑制剂公开(公告)号：US08377943B2
公开(公告)日：2013-02-19
申请号：US13128029
申请日：2009-11-13
IPC分类号： A61K31/506 , C07D239/48
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1-R3 and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R1-R3和n如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备具有上述药物的用途 提到的属性。
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公开(公告)号：US20110288071A1
公开(公告)日：2011-11-24
申请号：US13130669
申请日：2009-11-24
IPC分类号： A61K31/553 , C07D401/12 , C07D403/12 , C07D413/12 , C07D239/47 , A61P31/00 , C07D401/14 , C07D413/14 , A61K31/513 , A61K31/5377 , A61P29/00 , A61P35/00 , C07D405/14 , C07D405/12
CPC分类号： C07D413/14 , C07D239/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D419/14 , C07D493/04
摘要： The present invention encompasses compounds of general formula (1) wherein A, B, X, R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，B，X，R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备 具有上述特性的药物。
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