公开(公告)号：US11424116B2

公开(公告)日：2022-08-23

申请号：US17266246

申请日：2020-10-26

申请人： IonSense Inc.

发明人： Scott Oro ,  Brian D Musselman

IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection.

公开(公告)号：US20220262614A1

公开(公告)日：2022-08-18

申请号：US17708736

申请日：2022-03-30

申请人： IonSense, Inc.

发明人： Scott Oro ,  Brian Musselman

IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

摘要： This disclosure presents inventions for ionization, for example, for use in mass spectrometer devices and methods. In an embodiment, a device is provided for introduction of pulses of a first carrier gas into an ionization chamber and introduction of a second carrier gas into the ionization chamber. Electrodes in the chamber ionize the carrier gas and direct the ionized gas toward a sample for analysis. The second carrier gas can either assist in washing out the first carrier gas or may become ionized along with the first carrier gas to improve ionization of an analyte. In an embodiment, a method for producing ionized carrier gasses is provided.

公开(公告)号：US11615951B2

公开(公告)日：2023-03-28

申请号：US17708736

申请日：2022-03-30

申请人： IonSense, Inc.

发明人： Scott Oro ,  Brian Musselman

IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

摘要： This disclosure presents inventions for ionization, for example, for use in mass spectrometer devices and methods. In an embodiment, a device is provided for introduction of pulses of a first carrier gas into an ionization chamber and introduction of a second carrier gas into the ionization chamber. Electrodes in the chamber ionize the carrier gas and direct the ionized gas toward a sample for analysis. The second carrier gas can either assist in washing out the first carrier gas or may become ionized along with the first carrier gas to improve ionization of an analyte. In an embodiment, a method for producing ionized carrier gasses is provided.

公开(公告)号：US20220013347A1

公开(公告)日：2022-01-13

申请号：US17266246

申请日：2020-10-26

申请人： IonSense Inc..

发明人： Scott Oro ,  Brian D Musselman

IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection.