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    Delivery System
    1.
    发明申请
    Delivery System 审中-公开
    输送系统

    公开(公告)号：US20080063720A1

    公开(公告)日：2008-03-13

    申请号：US11587775

    申请日：2005-04-29

    申请人： Iouri Gounko ,  Yury Rakovich ,  Yuri Volkov ,  John Dongegan ,  Dermot Kelleher ,  Siobhan Mitchell

    发明人： Iouri Gounko ,  Yury Rakovich ,  Yuri Volkov ,  John Dongegan ,  Dermot Kelleher ,  Siobhan Mitchell

    IPC分类号： A61K9/14 ,  A61K47/00 ,  A61P25/00

    CPC分类号： A61K49/0067 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

    摘要： Therapeutic drug delivery and diagnostics systems comprise biologically active compounds associated with particulate carriers of less than 20 nm. These systems can be utilised for targeted modification of growth, development and functions, such as gene expression, protein synthesis, intracellular energy production and transport mechanisms in prokaryotic and eukaryotic organisms. The systems are also applicable for controlled modification of structural and functional properties of extracellular components and tissue constituents. The characteristics of a biological site are evaluated and an entity is provided which is dependent on the site characteristics. The entity comprises nanoparticles of less than 20 nm. A probe comprising nanoparticles of less than 5 nm is also provided.

    摘要翻译： 治疗药物递送和诊断系统包括与小于20nm的颗粒载体相关的生物活性化合物。 这些系统可用于生物，发育和功能的靶向修饰，如原核和真核生物中的基因表达，蛋白质合成，细胞内能量产生和转运机制。 该系统也适用于对细胞外组分和组织成分的结构和功能特性的可控修饰。 对生物部位的特征进行评估，并提供依赖于现场特征的实体。 该实体包含小于20nm的纳米颗粒。 还提供了包含小于5nm的纳米颗粒的探针。

    MULTI-WELL DEVICE
    3.
    发明申请
    MULTI-WELL DEVICE 审中-公开
    多设备

    公开(公告)号：US20110172128A1

    公开(公告)日：2011-07-14

    申请号：US13063828

    申请日：2009-09-14

    申请人： Anthony Davies ,  Dermot Kelleher ,  Yuri Volkov ,  Siobhan Mitchell

    发明人： Anthony Davies ,  Dermot Kelleher ,  Yuri Volkov ,  Siobhan Mitchell

    IPC分类号： C40B60/00

    CPC分类号： B01L3/50851 ,  B01L3/5085 ,  B01L2300/0829 ,  B01L2300/185

    摘要： A device comprising a plurality of sample wells wherein the device has a plurality of compartments, each compartment surrounding at least one well. The compartments are defined by compartment wall means. The compartment wall means may be associated with at least one well or the compartment wall means may be associated with a group of wells. The compartment may house an environmental buffering system.

    摘要翻译： 一种包括多个样品阱的装置，其中所述装置具有多个隔室，每个隔室围绕至少一个孔。 隔间由隔间壁装置限定。 隔室壁装置可以与至少一个井相关联，或者隔室壁装置可以与一组井相关联。 隔间可容纳环境缓冲系统。

    SUBSTANCE AND A DEVICE
    4.
    发明申请
    SUBSTANCE AND A DEVICE 有权
    物质和设备

    公开(公告)号：US20100197525A1

    公开(公告)日：2010-08-05

    申请号：US12450117

    申请日：2008-03-13

    申请人： Antony Davies ,  Siobhan Mitchell ,  Dermot Kelleher ,  Yuri Volkov

    发明人： Antony Davies ,  Siobhan Mitchell ,  Dermot Kelleher ,  Yuri Volkov

    IPC分类号： C40B60/00

    CPC分类号： B01L3/50853 ,  B01L3/5085 ,  B01L2300/045 ,  B01L2300/049 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/1883 ,  C12M23/12

    摘要： A device (1) for housing a scientific sample comprising at least one sample well (2) and an on-board buffering substance (3) wherein the onboard buffering substance (3) at least partly surrounds the sample well (2). The on-board buffering substance (3) may be in the form of a matrix, such as a gel-like matrix. The device (1) may further comprise an insulating means. Also described is a substance for use in culturing and/or assaying a sample whereby the substance provides atmospheric and thermal buffering. The invention further provides a lid for a single-well or multi-well sample plate, the lid being configured to facilitate delivery of a sample through the lid into a well, and for sealing the well. The lid comprises moveable portions (52, 53) that have at least one orifice (54, 57) formed through the moveable portions (52, 53) such that a conduit is formed by alignment of the orifices (54, 57) of both the lid portions (52, 53).

    摘要翻译： 一种用于容纳包含至少一个样品阱（2）和板上缓冲物质（3）的科学样品的装置（1），其中所述载板缓冲物质（3）至少部分地围绕所述样品井（2）。 板载缓冲物质（3）可以是基质的形式，例如凝胶状基质。 装置（1）还可以包括绝缘装置。 还描述了用于培养和/或测定样品的物质，由此物质提供大气和热缓冲。 本发明还提供了一种用于单井或多孔样品板的盖子，该盖子构造成便于将样品通过盖子输送到井中并用于密封井。 所述盖包括可移动部分（52,53），所述可移动部分具有通过所述可移动部分（52,53）形成的至少一个孔（54,57），使得通过所述孔的所述孔（54,57） 盖部分（52,53）。