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    MULTI-WELL DEVICE
    1.
    发明申请
    MULTI-WELL DEVICE 审中-公开
    多设备

    公开(公告)号：US20110172128A1

    公开(公告)日：2011-07-14

    申请号：US13063828

    申请日：2009-09-14

    申请人： Anthony Davies ,  Dermot Kelleher ,  Yuri Volkov ,  Siobhan Mitchell

    发明人： Anthony Davies ,  Dermot Kelleher ,  Yuri Volkov ,  Siobhan Mitchell

    IPC分类号： C40B60/00

    CPC分类号： B01L3/50851 ,  B01L3/5085 ,  B01L2300/0829 ,  B01L2300/185

    摘要： A device comprising a plurality of sample wells wherein the device has a plurality of compartments, each compartment surrounding at least one well. The compartments are defined by compartment wall means. The compartment wall means may be associated with at least one well or the compartment wall means may be associated with a group of wells. The compartment may house an environmental buffering system.

    摘要翻译： 一种包括多个样品阱的装置，其中所述装置具有多个隔室，每个隔室围绕至少一个孔。 隔间由隔间壁装置限定。 隔室壁装置可以与至少一个井相关联，或者隔室壁装置可以与一组井相关联。 隔间可容纳环境缓冲系统。

    Delivery System
    3.
    发明申请
    Delivery System 审中-公开
    输送系统

    公开(公告)号：US20080063720A1

    公开(公告)日：2008-03-13

    申请号：US11587775

    申请日：2005-04-29

    申请人： Iouri Gounko ,  Yury Rakovich ,  Yuri Volkov ,  John Dongegan ,  Dermot Kelleher ,  Siobhan Mitchell

    发明人： Iouri Gounko ,  Yury Rakovich ,  Yuri Volkov ,  John Dongegan ,  Dermot Kelleher ,  Siobhan Mitchell

    IPC分类号： A61K9/14 ,  A61K47/00 ,  A61P25/00

    CPC分类号： A61K49/0067 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

    摘要： Therapeutic drug delivery and diagnostics systems comprise biologically active compounds associated with particulate carriers of less than 20 nm. These systems can be utilised for targeted modification of growth, development and functions, such as gene expression, protein synthesis, intracellular energy production and transport mechanisms in prokaryotic and eukaryotic organisms. The systems are also applicable for controlled modification of structural and functional properties of extracellular components and tissue constituents. The characteristics of a biological site are evaluated and an entity is provided which is dependent on the site characteristics. The entity comprises nanoparticles of less than 20 nm. A probe comprising nanoparticles of less than 5 nm is also provided.

    摘要翻译： 治疗药物递送和诊断系统包括与小于20nm的颗粒载体相关的生物活性化合物。 这些系统可用于生物，发育和功能的靶向修饰，如原核和真核生物中的基因表达，蛋白质合成，细胞内能量产生和转运机制。 该系统也适用于对细胞外组分和组织成分的结构和功能特性的可控修饰。 对生物部位的特征进行评估，并提供依赖于现场特征的实体。 该实体包含小于20nm的纳米颗粒。 还提供了包含小于5nm的纳米颗粒的探针。

    SUBSTANCE AND A DEVICE
    4.
    发明申请
    SUBSTANCE AND A DEVICE 有权
    物质和设备

    公开(公告)号：US20100197525A1

    公开(公告)日：2010-08-05

    申请号：US12450117

    申请日：2008-03-13

    申请人： Antony Davies ,  Siobhan Mitchell ,  Dermot Kelleher ,  Yuri Volkov

    发明人： Antony Davies ,  Siobhan Mitchell ,  Dermot Kelleher ,  Yuri Volkov

    IPC分类号： C40B60/00

    CPC分类号： B01L3/50853 ,  B01L3/5085 ,  B01L2300/045 ,  B01L2300/049 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/1883 ,  C12M23/12

    摘要： A device (1) for housing a scientific sample comprising at least one sample well (2) and an on-board buffering substance (3) wherein the onboard buffering substance (3) at least partly surrounds the sample well (2). The on-board buffering substance (3) may be in the form of a matrix, such as a gel-like matrix. The device (1) may further comprise an insulating means. Also described is a substance for use in culturing and/or assaying a sample whereby the substance provides atmospheric and thermal buffering. The invention further provides a lid for a single-well or multi-well sample plate, the lid being configured to facilitate delivery of a sample through the lid into a well, and for sealing the well. The lid comprises moveable portions (52, 53) that have at least one orifice (54, 57) formed through the moveable portions (52, 53) such that a conduit is formed by alignment of the orifices (54, 57) of both the lid portions (52, 53).

    摘要翻译： 一种用于容纳包含至少一个样品阱（2）和板上缓冲物质（3）的科学样品的装置（1），其中所述载板缓冲物质（3）至少部分地围绕所述样品井（2）。 板载缓冲物质（3）可以是基质的形式，例如凝胶状基质。 装置（1）还可以包括绝缘装置。 还描述了用于培养和/或测定样品的物质，由此物质提供大气和热缓冲。 本发明还提供了一种用于单井或多孔样品板的盖子，该盖子构造成便于将样品通过盖子输送到井中并用于密封井。 所述盖包括可移动部分（52,53），所述可移动部分具有通过所述可移动部分（52,53）形成的至少一个孔（54,57），使得通过所述孔的所述孔（54,57） 盖部分（52,53）。

    Substance and a device
    5.
    发明授权
    Substance and a device 有权
    物质和设备

    公开(公告)号：US08337785B2

    公开(公告)日：2012-12-25

    申请号：US12450117

    申请日：2008-03-13

    申请人： Anthony Davies ,  Slobhan Mitchell ,  Dermot Kelleher ,  Yuri Volkov

    发明人： Anthony Davies ,  Slobhan Mitchell ,  Dermot Kelleher ,  Yuri Volkov

    IPC分类号： B01L3/00 ,  G01N31/00 ,  C40B60/00 ,  C12M1/18

    CPC分类号： B01L3/50853 ,  B01L3/5085 ,  B01L2300/045 ,  B01L2300/049 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/1883 ,  C12M23/12

    摘要： A device (1) for housing a scientific sample comprising at least one sample well (2) and an on-board buffering substance (3) wherein the onboard buffering substance (3) at least partly surrounds the sample well (2). The on-board buffering substance (3) may be in the form of a matrix, such as a gel-like matrix. The device (1) may further comprise an insulating means. Also described is a substance for use in culturing and/or assaying a sample whereby the substance provides atmospheric and thermal buffering. The invention further provides a lid for a single-well or multi-well sample plate, the lid being configured to facilitate delivery of a sample through the lid into a well, and for sealing the well. The lid comprises moveable portions (52, 53) that have at least one orifice (54, 57) formed through the moveable portions (52, 53) such that a conduit is formed by alignment of the orifices (54, 57) of both the lid portions (52, 53).

    摘要翻译： 一种用于容纳包含至少一个样品阱（2）和板上缓冲物质（3）的科学样品的装置（1），其中所述载板缓冲物质（3）至少部分地围绕所述样品井（2）。 板载缓冲物质（3）可以是基质的形式，例如凝胶状基质。 装置（1）还可以包括绝缘装置。 还描述了用于培养和/或测定样品的物质，由此物质提供大气和热缓冲。 本发明还提供了一种用于单井或多孔样品板的盖子，该盖子构造成便于将样品通过盖子输送到井中并用于密封井。 所述盖包括可移动部分（52,53），所述可移动部分具有通过所述可移动部分（52,53）形成的至少一个孔（54,57），使得通过所述孔的所述孔（54,57） 盖部分（52,53）。

    Biological assay method
    7.
    发明授权
    Biological assay method 有权
    生物检测方法

    公开(公告)号：US06770434B2

    公开(公告)日：2004-08-03

    申请号：US09750348

    申请日：2000-12-29

    申请人： Igor Shvets ,  Dmitriy Kashanin ,  Dermot Kelleher ,  Vivienne Williams ,  Yuri Volkov

    发明人： Igor Shvets ,  Dmitriy Kashanin ,  Dermot Kelleher ,  Vivienne Williams ,  Yuri Volkov

    IPC分类号： C12Q100

    CPC分类号： G01N33/5005 ,  B01L3/5027 ,  B01L3/502761 ,  B01L3/5635 ,  B01L2200/027 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/163 ,  B01L2400/0487

    摘要： Biological assays using various constructions of biochips are disclosed to mirror in vivo situations. The biochip 50 comprises a microchannel 51 having a liquid outlet port 1, bubble release port 2 and a liquid outlet port 3 with an associated bubble release port 4. A multiplicity of tests can be performed often by coating the bore of the microchannel 50 which various adhesion mediating proteins or the use of chemoattractants. The assay assembly 60 comprises a syringe pump feeding the biochip 50. An inverted microscope 65, digital camera 66 and recorder 67 are provided. A sample liquid containing cells in suspension is injected slowly through the biochip and the effect of the assay recorded over a long period.

    摘要翻译： 公开了使用生物芯片的各种构造的生物测定来体现体内情况。 生物芯片50包括具有液体出口1，气泡释放口2和具有相关联的气泡释放口4的液体出口3的微通道51.可以经常通过涂覆微通道50的孔来进行多种测试， 粘附介导蛋白或使用化学引诱物。 测定组件60包括供给生物芯片50的注射泵。提供倒置显微镜65，数字照相机66和记录器67。 将含有悬浮液中的细胞的样品液体缓慢注入生物芯片，并且测定长时间的记录效果。

    METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUAL WITH INFECTION
    10.
    发明申请
    METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUAL WITH INFECTION 审中-公开
    估计个体感染感染风险的方法

    公开(公告)号：US20120149785A1

    公开(公告)日：2012-06-14

    申请号：US13123559

    申请日：2009-10-09

    申请人： Thomas Ryan ,  Mary White ,  Owen Ross McManus ,  Dermot Kelleher

    发明人： Thomas Ryan ,  Mary White ,  Owen Ross McManus ,  Dermot Kelleher

    IPC分类号： C12Q1/68 ,  A61K35/00 ,  A61P31/00 ,  G01N21/59

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： A method of estimating sepsis risk in an individual with infection comprises a step of assaying a biological sample from the individual for an IL-2 or IL-7 mRNA value, and correlating the mRNA value with sepsis risk. The IL-2 and IL-7 mRNA values are quantified by absolute quantification of mRNA copy number, wherein the copy numbers are normalised to a house keeping gene and corrected against a calibration curve for serial dilutions of the IL-2 and IL-7 cDNA. The method generally involves a step of assaying a biological sample from the individual for IL-2 and/or IL-7 mRNA values, optionally in combination with mRNA values for other cytokines, and correlating a sum or difference of the values with sepsis risk using a regression analysis curve against outcome.

    摘要翻译： 评估患有感染个体的败血症风险的方法包括测定来自个体的IL-2或IL-7mRNA值的生物样品，并将mRNA值与败血症风险相关联的步骤。 通过mRNA拷贝数的绝对定量来定量IL-2和IL-7mRNA值，其中拷贝数被归一化到家庭保持基因，并且针对用于连续稀释IL-2和IL-7 cDNA的校准曲线进行校正 。 该方法通常包括从个体测定IL-2和/或IL-7mRNA值的生物学样品的步骤，任选地与其它细胞因子的mRNA值组合，并且将该值与脓毒症风险的总和或差值相关联，使用 对结果的回归分析曲线。