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    DETECTION OF HIGH GRADE DYSPLASIA IN CERVICAL CELLS
    2.
    发明申请
    DETECTION OF HIGH GRADE DYSPLASIA IN CERVICAL CELLS 审中-公开
    检测宫颈细胞中的高等级DYSPLASIA

    公开(公告)号：US20120164626A1

    公开(公告)日：2012-06-28

    申请号：US13279947

    申请日：2011-10-24

    申请人： Irina A. Sokolova ,  Steven A. Seelig ,  Larry E. Morrison ,  Walter King ,  Alicia Algeciras-Schimnich

    发明人： Irina A. Sokolova ,  Steven A. Seelig ,  Larry E. Morrison ,  Walter King ,  Alicia Algeciras-Schimnich

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112

    摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

    摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。

    Detection of high grade dysplasia in cervical cells
    3.
    发明授权
    Detection of high grade dysplasia in cervical cells 有权
    检测宫颈细胞高度发育不良

    公开(公告)号：US08043805B2

    公开(公告)日：2011-10-25

    申请号：US12422859

    申请日：2009-04-13

    申请人： Irina A. Sokolova ,  Steven A. Seelig ,  Larry E. Morrison ,  Walter King ,  Alicia Algeciras-Schimnich

    发明人： Irina A. Sokolova ,  Steven A. Seelig ,  Larry E. Morrison ,  Walter King ,  Alicia Algeciras-Schimnich

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/112

    摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

    摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。

    Detection of high grade dysplasia in cervical cells
    4.
    发明授权
    Detection of high grade dysplasia in cervical cells 有权
    检测宫颈细胞高度发育不良

    公开(公告)号：US07517645B2

    公开(公告)日：2009-04-14

    申请号：US10857859

    申请日：2004-06-02

    申请人： Irina A. Sokolova ,  Steven A. Seelig ,  Larry E. Morrison ,  Walter King ,  Alicia Algeciras-Schimnich

    发明人： Irina A. Sokolova ,  Steven A. Seelig ,  Larry E. Morrison ,  Walter King ,  Alicia Algeciras-Schimnich

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/112

    摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

    摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级发育不良或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。