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公开(公告)号：US10351912B2
公开(公告)日：2019-07-16
申请号：US13279947
申请日：2011-10-24
申请人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
发明人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
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公开(公告)号：US20120164626A1
公开(公告)日：2012-06-28
申请号：US13279947
申请日：2011-10-24
申请人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
发明人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。
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公开(公告)号：US08043805B2
公开(公告)日：2011-10-25
申请号：US12422859
申请日：2009-04-13
申请人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
发明人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。
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公开(公告)号：US07517645B2
公开(公告)日：2009-04-14
申请号：US10857859
申请日：2004-06-02
申请人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
发明人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级发育不良或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。
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公开(公告)号：US20050026190A1
公开(公告)日：2005-02-03
申请号：US10857859
申请日：2004-06-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
摘要翻译： 描述了使用探针和探针组检测宫颈细胞中高度发育异常和癌症的方法。 本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。 本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。
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公开(公告)号：US20130237590A1
公开(公告)日：2013-09-12
申请号：US13810363
申请日：2011-07-14
申请人： Norman L. Eberhardt , Bryan Mciver , Stefan K.G. Grebe , Honey V. Reddi , Alicia Algeciras-Schimnich
发明人： Norman L. Eberhardt , Bryan Mciver , Stefan K.G. Grebe , Honey V. Reddi , Alicia Algeciras-Schimnich
IPC分类号： A61K31/7088
CPC分类号： A61K31/7088 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： This document provides methods and materials involved in assessing thyroid neoplasms. For example, methods and materials for using microRNA (miR) levels (e.g., miR122 levels) to determine whether a thyroid neoplasm (e.g., a follicular thyroid neoplasm) is benign or malignant as well as methods and materials for using miR levels (e.g., miR122 levels) to determine whether a malignant thyroid cancer patient is likely to have a favorable or unfavorable outcome are provided. This document also provides methods and materials involved in treating cancer.
摘要翻译： 本文档提供了评估甲状腺肿瘤的方法和材料。 例如，使用microRNA（miR）水平（例如miR122水平）来确定甲状腺肿瘤（例如，滤泡性甲状腺肿瘤）是良性还是恶性的方法和材料以及使用miR水平的方法和材料（例如， miR122水平）以确定恶性甲状腺癌患者是否可能具有有利或不利的结果。 本文件还提供了治疗癌症的方法和材料。
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