公开(公告)号：US06635479B1

公开(公告)日：2003-10-21

申请号：US09230896

申请日：1999-02-02

申请人： J. Gregor Sutcliffe ,  Kaare M. Gautvik ,  Luis De Lecea ,  Floyd E. Bloom ,  Patria E. Danielson ,  Vigdis T. Gautvik ,  Thomas S. Kilduff ,  Pamela E. Foye

发明人： J. Gregor Sutcliffe ,  Kaare M. Gautvik ,  Luis De Lecea ,  Floyd E. Bloom ,  Patria E. Danielson ,  Vigdis T. Gautvik ,  Thomas S. Kilduff ,  Pamela E. Foye

IPC分类号： C07H2104

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： Disclosed are hypocretin polynucleotides and hypocretin polypeplides, as well as antibodies, oligonucleotides, diagnostic kits and methods, and therapeutic compositions and methods. Hypocretin, one of several novel liypothalamic-specific polypeptides identified isolated and sequenced, is localized to regions of the hypothalamus involved in appetite and feeding behavior. Hypocretin polypeptides are biologically active, producing electrical changes in neurons, lowering body temperature and reducing food intake.

摘要翻译： 公开了下丘脑多核苷酸和下丘脑多聚肽，以及抗体，寡核苷酸，诊断试剂盒和方法以及治疗组合物和方法。 识别分离和测序的几种新型下丘脑特异性多肽之一的下丘脑定位于涉及食欲和摄食行为的下丘脑区域。 下丘脑多肽具有生物活性，在神经元中产生电变化，降低体温并减少食物摄入。