公开(公告)号：US20230399297A1

公开(公告)日：2023-12-14

申请号：US18031893

申请日：2021-10-14

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Runze LI ,  Cunbo MA ,  Zhenchang LIAN ,  Jing XIONG ,  Yanping WANG ,  Wei LONG

IPC: C07D209/20 ,  C07C245/18 ,  C07D305/08 ,  C07D307/16 ,  C07D211/66 ,  C07D309/06 ,  C07D307/93 ,  C07D309/08 ,  C07D207/09 ,  C07D493/04 ,  C07D277/30 ,  C07D207/337 ,  C07D263/32 ,  C07D233/64 ,  C07D333/24 ,  C07D213/74 ,  C07D239/20 ,  C07D213/30 ,  C07D313/04 ,  C07D265/30 ,  C07D331/04 ,  A61P35/00

CPC classification number: C07D209/20 ,  C07C245/18 ,  C07D305/08 ,  C07D307/16 ,  C07D211/66 ,  C07D309/06 ,  C07D307/93 ,  C07D309/08 ,  C07D207/09 ,  C07D493/04 ,  C07D277/30 ,  C07D207/337 ,  C07D263/32 ,  C07D233/64 ,  C07D333/24 ,  C07D213/74 ,  C07D239/20 ,  C07D213/30 ,  C07D313/04 ,  C07D265/30 ,  C07D331/04 ,  A61P35/00 ,  C07C2601/18 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/04 ,  C07C2601/02 ,  C07C2601/08

Abstract: The invention relates to novel glutamine analogs, a composition containing the glutamine analogs and the use thereof.

公开(公告)号：US20240400591A1

公开(公告)日：2024-12-05

申请号：US18682463

申请日：2022-08-09

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Sujing LI ,  Amin LI ,  Qian ZHENG ,  Chaojie DANG ,  Xinrui FAN ,  Wei LONG ,  Yanping WANG

IPC: C07F9/6558 ,  A61K31/397 ,  A61K31/403 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/67 ,  A61K31/675 ,  C07D333/58 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/04 ,  C07D491/107 ,  C07D495/04 ,  C07F9/6568 ,  C07F9/6584

Abstract: Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.

公开(公告)号：US20240376128A1

公开(公告)日：2024-11-14

申请号：US18684203

申请日：2022-08-17

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Hongwei YANG ,  Cunbo MA ,  Panliang GAO ,  Huifeng HAN ,  Peng WANG ,  Runze LI ,  Xiaoyu LIU ,  Yanping WANG ,  Wei LONG ,  Wei ZHANG

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/675 ,  C07F9/6561

Abstract: Provided herein is a compound of Formula (IB), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer thereof, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof; composition containing the same and the use thereof.

公开(公告)号：US20240336629A1

公开(公告)日：2024-10-10

申请号：US18276269

申请日：2022-01-26

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Haijun LI ,  Mingming CHEN ,  Di KANG ,  Qinglong LI ,  Lei ZHANG ,  Man YAN ,  Wei LONG ,  Yanping WANG ,  Hao ZHANG ,  Cunbo MA ,  Amin LI

IPC: C07D513/14 ,  C07D471/14 ,  C07D498/14 ,  C12N9/99

CPC classification number: C07D513/14 ,  C07D471/14 ,  C07D498/14 ,  C12N9/99

Abstract: Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.

公开(公告)号：US20220119390A1

公开(公告)日：2022-04-21

申请号：US17561381

申请日：2021-12-23

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Haiquan FANG ,  Mingming CHEN ,  Guiqun YANG ,  Yuelei DU ,  Yanping WANG ,  Tong WU ,  Qinglong LI ,  Lei ZHANG ,  Shaojing HU

IPC: C07D471/14 ,  A61P35/00

Abstract: Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

公开(公告)号：US20250034166A1

公开(公告)日：2025-01-30

申请号：US18695384

申请日：2022-09-26

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Hongwei YANG ,  Cunbo MA ,  Panliang GAO ,  Huifeng HAN ,  Peng WANG ,  Runze LI ,  Wei ZHANG ,  Xiaoyu LIU ,  Yanping WANG ,  Wei LONG

IPC: C07D519/00

Abstract: Provided are K-Ras mutant protein inhibitors of formula (I), a composition containing the same and the use thereof.

公开(公告)号：US20250019377A1

公开(公告)日：2025-01-16

申请号：US18684205

申请日：2022-08-17

Applicant: JACOBIO PHARMACEUTICALS CO., LTD

Inventor： Hongwei YANG ,  Cunbo MA ,  Panliang GAO ,  Huifeng HAN ,  Peng WANG ,  Runze LI ,  Xiaoyu LIU ,  Yanping WANG ,  Wei LONG ,  Wei ZHANG

IPC: C07D471/04 ,  A61K31/553 ,  A61P35/00 ,  C07D413/14 ,  C07D487/04 ,  C07D519/00

Abstract: A Compound of formula (I) or (II), a stereoisomer thereof, an atropisomer, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer, a pharmaceutically acceptable salt of the atropisomer, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof is disclosed:

公开(公告)号：US20240376075A1

公开(公告)日：2024-11-14

申请号：US18292360

申请日：2022-07-27

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Haijun LI ,  Guiqun YANG ,  Wei LONG ,  Yanping WANG

IPC: C07D401/14 ,  A61K31/4545

Abstract: Provided herein are salts of the compound 1 and new poly morph forms thereof, pharmaceutical composition including the compound 1 and new polymorph forms thereof, and methods of preparing them and using them.

公开(公告)号：US20240199548A1

公开(公告)日：2024-06-20

申请号：US18283834

申请日：2022-03-25

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Yang YE ,  Xiuwei LI ,  Guiqun YANG ,  Fashun YAN ,  Yanping WANG ,  Wei LONG

IPC: C07D209/44 ,  A61K31/4035 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04

CPC classification number: C07D209/44 ,  A61K31/4035 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04

Abstract: Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.

公开(公告)号：US20240116909A1

公开(公告)日：2024-04-11

申请号：US18284897

申请日：2022-03-29

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Yang YE ,  Xiuwei LI ,  Guiqun YANG ,  Fashun YAN ,  Yanping WANG ,  Wei LONG

IPC: C07D409/12 ,  C07D495/04 ,  C07D519/00 ,  C07D495/14 ,  C07D471/04

CPC classification number: C07D409/12 ,  C07D495/04 ,  C07D519/00 ,  C07D495/14 ,  C07D471/04

Abstract: Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.