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公开(公告)号:US20240199644A1
公开(公告)日:2024-06-20
申请号:US18280487
申请日:2022-03-07
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor: Huifeng HAN , Panliang GAO , Cunbo MA , Peng WANG , Wei LONG , Hao ZHANG , Lei ZHANG , Dan LIU
IPC: C07D498/16 , A61K31/553 , C07D498/22 , C07D519/00
CPC classification number: C07D498/16 , A61K31/553 , C07D498/22 , C07D519/00
Abstract: The invention relates to a KRAS G12D inhibitors of formula (I) or formula (IV), a composition containing the inhibitor and the use thereof
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公开(公告)号:US20230399297A1
公开(公告)日:2023-12-14
申请号:US18031893
申请日:2021-10-14
Applicant: Jacobio Pharmaceuticals Co., Ltd.
Inventor: Runze LI , Cunbo MA , Zhenchang LIAN , Jing XIONG , Yanping WANG , Wei LONG
IPC: C07D209/20 , C07C245/18 , C07D305/08 , C07D307/16 , C07D211/66 , C07D309/06 , C07D307/93 , C07D309/08 , C07D207/09 , C07D493/04 , C07D277/30 , C07D207/337 , C07D263/32 , C07D233/64 , C07D333/24 , C07D213/74 , C07D239/20 , C07D213/30 , C07D313/04 , C07D265/30 , C07D331/04 , A61P35/00
CPC classification number: C07D209/20 , C07C245/18 , C07D305/08 , C07D307/16 , C07D211/66 , C07D309/06 , C07D307/93 , C07D309/08 , C07D207/09 , C07D493/04 , C07D277/30 , C07D207/337 , C07D263/32 , C07D233/64 , C07D333/24 , C07D213/74 , C07D239/20 , C07D213/30 , C07D313/04 , C07D265/30 , C07D331/04 , A61P35/00 , C07C2601/18 , C07C2601/14 , C07C2601/16 , C07C2601/04 , C07C2601/02 , C07C2601/08
Abstract: The invention relates to novel glutamine analogs, a composition containing the glutamine analogs and the use thereof.
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公开(公告)号:US20240059710A1
公开(公告)日:2024-02-22
申请号:US18037801
申请日:2021-11-19
Applicant: Jacobio Pharmaceuticals Co., Ltd.
Inventor: Huifeng HAN , Panliang GAO , Wenlong ZHANG , Cunbo MA , Peng WANG , Dan LIU , Hao ZHANG , Wei LONG
IPC: C07D519/00 , C07D487/08 , A61P35/00
CPC classification number: C07D519/00 , C07D487/08 , A61P35/00
Abstract: KRAS G12D inhibitors of Formula (I), a composition containing the inhibitor and the use thereof.
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公开(公告)号:US20240025918A1
公开(公告)日:2024-01-25
申请号:US18037809
申请日:2021-11-19
Applicant: Jacobio Pharmaceuticals Co., Ltd
Inventor: Huifeng HAN , Panliang GAO , Wenlong ZHANG , Cunbo MA , Peng WANG , Dan LIU , Hao ZHANG , Wei LONG
IPC: C07D519/00 , C07D487/08
CPC classification number: C07D519/00 , C07D487/08
Abstract: Provided are KRAS G12D inhibitors of formula (I), a composition containing the inhibitors, a prodrug thereof, a PROTAC compound thereof and the use thereof.
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公开(公告)号:US20240400591A1
公开(公告)日:2024-12-05
申请号:US18682463
申请日:2022-08-09
Applicant: Jacobio Pharmaceuticals Co., Ltd.
Inventor: Sujing LI , Amin LI , Qian ZHENG , Chaojie DANG , Xinrui FAN , Wei LONG , Yanping WANG
IPC: C07F9/6558 , A61K31/397 , A61K31/403 , A61K31/438 , A61K31/439 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/67 , A61K31/675 , C07D333/58 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/04 , C07D491/107 , C07D495/04 , C07F9/6568 , C07F9/6584
Abstract: Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.
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公开(公告)号:US20240376128A1
公开(公告)日:2024-11-14
申请号:US18684203
申请日:2022-08-17
Applicant: Jacobio Pharmaceuticals Co., Ltd.
Inventor: Hongwei YANG , Cunbo MA , Panliang GAO , Huifeng HAN , Peng WANG , Runze LI , Xiaoyu LIU , Yanping WANG , Wei LONG , Wei ZHANG
IPC: C07D519/00 , A61K31/519 , A61K31/675 , C07F9/6561
Abstract: Provided herein is a compound of Formula (IB), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer thereof, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof; composition containing the same and the use thereof.
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公开(公告)号:US20240336629A1
公开(公告)日:2024-10-10
申请号:US18276269
申请日:2022-01-26
Applicant: JACOBIO PHARMACEUTICALS CO., LTD.
Inventor: Haijun LI , Mingming CHEN , Di KANG , Qinglong LI , Lei ZHANG , Man YAN , Wei LONG , Yanping WANG , Hao ZHANG , Cunbo MA , Amin LI
IPC: C07D513/14 , C07D471/14 , C07D498/14 , C12N9/99
CPC classification number: C07D513/14 , C07D471/14 , C07D498/14 , C12N9/99
Abstract: Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.
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公开(公告)号:US20250034166A1
公开(公告)日:2025-01-30
申请号:US18695384
申请日:2022-09-26
Applicant: Jacobio Pharmaceuticals Co., Ltd.
Inventor: Hongwei YANG , Cunbo MA , Panliang GAO , Huifeng HAN , Peng WANG , Runze LI , Wei ZHANG , Xiaoyu LIU , Yanping WANG , Wei LONG
IPC: C07D519/00
Abstract: Provided are K-Ras mutant protein inhibitors of formula (I), a composition containing the same and the use thereof.
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公开(公告)号:US20250019377A1
公开(公告)日:2025-01-16
申请号:US18684205
申请日:2022-08-17
Applicant: JACOBIO PHARMACEUTICALS CO., LTD
Inventor: Hongwei YANG , Cunbo MA , Panliang GAO , Huifeng HAN , Peng WANG , Runze LI , Xiaoyu LIU , Yanping WANG , Wei LONG , Wei ZHANG
IPC: C07D471/04 , A61K31/553 , A61P35/00 , C07D413/14 , C07D487/04 , C07D519/00
Abstract: A Compound of formula (I) or (II), a stereoisomer thereof, an atropisomer, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer, a pharmaceutically acceptable salt of the atropisomer, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof is disclosed:
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公开(公告)号:US20240376075A1
公开(公告)日:2024-11-14
申请号:US18292360
申请日:2022-07-27
Applicant: Jacobio Pharmaceuticals Co., Ltd.
Inventor: Haijun LI , Guiqun YANG , Wei LONG , Yanping WANG
IPC: C07D401/14 , A61K31/4545
Abstract: Provided herein are salts of the compound 1 and new poly morph forms thereof, pharmaceutical composition including the compound 1 and new polymorph forms thereof, and methods of preparing them and using them.
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