公开(公告)号：US20220305056A1

公开(公告)日：2022-09-29

申请号：US17637946

申请日：2020-08-26

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Bharathikumar Vellalore MARUTHACHALAM ,  Sathyadevi VENKATARAMANI ,  Iqbal GREWAL ,  Sanjaya SINGH ,  Paul HARVILLA ,  Martin Jack BORROK III ,  Ninkka TAMOT ,  Yonghai LI

IPC: A61K35/17 ,  C07K16/44 ,  C07K16/30 ,  C07K16/28 ,  C07K14/725 ,  A61P35/00

Abstract: Provided herein are chimeric antigen receptors (CARs), cells comprising the CARs, monoclonal and bispecific antibodies or antigen-binding fragments thereof, and kits comprising the same. The CARs and bispecific antibodies are designed to target at least one tumor antigen and at least one tumor in methods of treating cancer in subjects in need thereof.