公开(公告)号：US20220324970A1

公开(公告)日：2022-10-13

申请号：US17630718

申请日：2020-07-31

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Bharathikumar Vellalore MARUTHACHALAM ,  Adam ZWOLAK ,  Brian GEIST ,  Xiefan LIN-SCHMIDT ,  Sathyadevi VENKATARAMANI ,  Sanjaya SINGH

IPC: C07K16/28 ,  A61K47/68 ,  A61K47/65

Abstract: A method is described for delivering a single domain antibody or a therapeutic molecule from an apical surface of a polymeric immunoglobulin receptor (pIgR)-expressing cell to a basolateral surface of the pIgR-expressing cell comprising contacting the pIgR-expressing cell with the single domain antibody or the therapeutic molecule, wherein the single domain antibody binds to pIgR, and the therapeutic molecule comprises an agent and the single domain antibody. A method is also described for transporting such a therapeutic molecule to systemic circulation or lamina propria or gastrointestinal tract of a subject comprising administering the therapeutic molecule to the subject via oral delivery, buccal delivery, nasal delivery or inhalation delivery.

公开(公告)号：US20210395697A1

公开(公告)日：2021-12-23

申请号：US17349328

申请日：2021-06-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： Iqbal S. GREWAL ,  Rajkumar GANESAN ,  Sanjaya SINGH

IPC: C12N5/074 ,  C12N15/86 ,  A61K35/545

Abstract: Provided here in are methods of producing induced pluripotent stem cells (iPSCs) and isolated population of produced induced pluripotent stem cells (iPSCs). Also provided herein are methods of treating a subject in need thereof using the produced iPSCs or pharmaceutical compositions comprising the produced iPSCs.

公开(公告)号：US20240293453A1

公开(公告)日：2024-09-05

申请号：US17906040

申请日：2021-03-15

Applicant: Janssen Biotech, Inc.

Inventor： Patrick John DOONAN ,  Rajkumar GANESAN ,  Mehabaw Getahun DEREBE ,  Sathyadevi VENKATARAMANI ,  Sanjaya SINGH ,  Iqbal S. GREWAL ,  Karla R. WIEHAGEN

IPC: A61K35/17 ,  A61K39/00 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464411 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K51/1096 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/2803 ,  A61K2239/13 ,  A61K2239/17 ,  A61K2239/21 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/31

Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20220305056A1

公开(公告)日：2022-09-29

申请号：US17637946

申请日：2020-08-26

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Bharathikumar Vellalore MARUTHACHALAM ,  Sathyadevi VENKATARAMANI ,  Iqbal GREWAL ,  Sanjaya SINGH ,  Paul HARVILLA ,  Martin Jack BORROK III ,  Ninkka TAMOT ,  Yonghai LI

IPC: A61K35/17 ,  C07K16/44 ,  C07K16/30 ,  C07K16/28 ,  C07K14/725 ,  A61P35/00

Abstract: Provided herein are chimeric antigen receptors (CARs), cells comprising the CARs, monoclonal and bispecific antibodies or antigen-binding fragments thereof, and kits comprising the same. The CARs and bispecific antibodies are designed to target at least one tumor antigen and at least one tumor in methods of treating cancer in subjects in need thereof.

公开(公告)号：US20220267472A1

公开(公告)日：2022-08-25

申请号：US17672471

申请日：2022-02-15

Applicant: Janssen Biotech, Inc.

Inventor： Sanjaya SINGH ,  Rajkumar GANESAN ,  Jun CHEN ,  Iqbal S. GREWAL

IPC: C07K16/42 ,  G01N33/68

Abstract: Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.

公开(公告)号：US20210355442A1

公开(公告)日：2021-11-18

申请号：US17190566

申请日：2021-03-03

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar GANESAN ,  Iqbal S. GREWAL ,  Sanjaya SINGH

IPC: C12N5/0783 ,  A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30

Abstract: Provided are methods of expanding and isolating γδ T cells from human peripheral blood mononuclear cells (PBMCs). Also provided are isolated γδ T cells, CAR-γδ T cells, and methods of using the same.

公开(公告)号：US20250043004A1

公开(公告)日：2025-02-06

申请号：US18912192

申请日：2024-10-10

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Michael Riis HANSEN ,  Iqbal S. GREWAL ,  Sanjaya SINGH

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C07K16/46

Abstract: Provided herein are trispecific antibodies or antigen binding fragments thereof that bind to Vβ17, CD28 and another target (e.g., a cancer antigen, such as BCMA or PSMA) are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.

公开(公告)号：US20240150464A1

公开(公告)日：2024-05-09

申请号：US18306401

申请日：2023-04-25

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar GANESAN ,  Iqbal S. GREWAL ,  Sanjaya SINGH

IPC: C07K16/28 ,  A61K38/17

CPC classification number: C07K16/2809 ,  A61K38/1709 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565

Abstract: Anti-TRGV9 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.

公开(公告)号：US20230174651A1

公开(公告)日：2023-06-08

申请号：US17844484

申请日：2022-06-20

Applicant: Janssen Biotech, Inc.

Inventor： Jun CHEN ,  Martin Jack BORROK, III ,  Rajkumar GANESAN ,  Degang SONG ,  Shixue SHEN ,  Bonnie WU

IPC: C07K16/28 ,  G01N33/50 ,  G01N33/68

CPC classification number: C07K16/2815 ,  G01N33/5005 ,  G01N33/68 ,  C07K2317/622 ,  C07K2317/565 ,  C07K2317/24 ,  C07K2317/21 ,  G01N2333/70517

Abstract: An antibody that binds a CD8α hinge region, wherein the antibody is capable of binding to a functional exogenous receptor, and wherein the functional exogenous receptor comprises an extracellular domain, the CD8α hinge region, a transmembrane domain, and an intracellular signaling domain.

公开(公告)号：US20220356266A1

公开(公告)日：2022-11-10

申请号：US17233021

申请日：2021-04-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Adam ZWOLAK ,  Jason HO ,  Natasa OBERMAJER ,  Michael DIEM ,  Sanjaya SINGH ,  Sathyadevi VENKATARAMANI ,  Theresa MCDEVITT ,  Fei SHEN

IPC: C07K16/30 ,  C07K16/28

Abstract: A population of antibodies, wherein less than 80% of the oligosaccharides covalently attached to the population of the antibodies via N297 residues thereof comprise a core fucose residue; and wherein the population of the antibodies comprises an antibody which Fc region comprises K338A and T437R mutations, or K248E and T437R mutations.