公开(公告)号：US20210214440A1

公开(公告)日：2021-07-15

申请号：US17125162

申请日：2020-12-17

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  Sanjaya Singh ,  Iqbal S. Grewal ,  Michael Riis Hansen

IPC: C07K16/28 ,  B01D15/00

Abstract: An isolated molecule, comprising: a first antigen binding domain and a second antigen binding domain, wherein the first antigen binding domain specifically binds CD8 and the second antigen binding domain specifically binds a T cell receptor (TCR) complex.

公开(公告)号：US12076413B2

公开(公告)日：2024-09-03

申请号：US17512195

申请日：2021-10-27

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar Ganesan ,  Iqbal S. Grewal ,  Sanjaya Singh ,  Michael Riis Hansen

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/00

CPC classification number: A61K47/6897 ,  C07K16/2809 ,  A61K39/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

Abstract: Provided herein, in certain aspects, are antibodies that bind to T cell receptor (TCR) Vγ9 (TRGV9), TCR Vδ2 (TRDV2), or the TCR gamma/delta constant region (TRGDC), as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making and using the antibodies are also provided.

公开(公告)号：US11965024B2

公开(公告)日：2024-04-23

申请号：US17472198

申请日：2021-09-10

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar Ganesan ,  Iqbal S. Grewal ,  Sanjaya Singh ,  Michael Riis Hansen

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/30 ,  C12N5/0783

CPC classification number: C07K16/2809 ,  A61P35/00 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/3069 ,  C12N5/0636 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/92

Abstract: Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.

公开(公告)号：US20240247063A1

公开(公告)日：2024-07-25

申请号：US18609023

申请日：2024-03-19

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  Iqbal S. Grewal ,  Sanjaya Singh ,  Michael Riis Hansen

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12N5/0783 ,  A61K39/00

CPC classification number: C07K16/2809 ,  A61P35/00 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/3069 ,  C12N5/0636 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/92

Abstract: Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.

公开(公告)号：US11926667B2

公开(公告)日：2024-03-12

申请号：US17499597

申请日：2021-10-12

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar Ganesan ,  Sanjaya Singh ,  Iqbal S. Grewal ,  Michael Riis Hansen

IPC: C07K16/28 ,  C07K16/46

CPC classification number: C07K16/2812 ,  C07K16/2815 ,  C07K16/468 ,  C07K2317/34 ,  C07K2317/565

Abstract: Provided herein, in certain aspects, are antibodies that bind to CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are antibodies that bind to CD4, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are multispecific antibodies that bind to CD4 and CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making the antibodies are also provided.