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公开(公告)号：US11952411B2
公开(公告)日：2024-04-09
申请号：US17405872
申请日：2021-08-18
Applicant: JANSSEN BIOTECH, INC.
Inventor： Adam Zwolak , Szeman Chan , Rajkumar Ganesan
IPC: C07K14/705 , A61K38/00 , A61P37/04 , C07K14/765
CPC classification number: C07K14/70575 , A61P37/04 , C07K14/765 , A61K38/00 , C07K2319/30 , C07K2319/31 , C07K2319/74
Abstract: Described herein are compositions and kits that comprise an engineered TL1A ligand that displays high stability, minimal binding to decoy receptor DcR3 while retaining functional activity via binding to its cell surface receptor, DR3, and the ability to activate T cells in vitro and in vivo. Methods of making an engineered TL1A ligand and methods of treating a disease or disorder in a subject by administering an engineered TL1A ligand are also provided.
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公开(公告)号：US20230250171A1
公开(公告)日：2023-08-10
申请号：US18307146
申请日：2023-04-26
Applicant: Janssen Biotech, Inc.
Inventor： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC classification number: C07K16/2803 , C07K16/2809 , C07K16/2815 , C07K16/2827 , C07K16/2866 , C07K16/2818 , A61P35/00 , A61K39/4631 , A61K39/464411 , C07K2317/622 , C07K2319/31 , C07K2317/31 , C07K2317/22 , C07K2317/21
Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US20220411504A1
公开(公告)日：2022-12-29
申请号：US17330462
申请日：2021-05-26
Applicant: Janssen Biotech, Inc.
Inventor： Raymond Brittingham , Scott R. Brodeur , Rajkumar Ganesan , Jaclyn Hoover , Steven A. Jacobs , Colleen M. Kane , Jinquan Luo , Sanjaya Singh , Fang Yi , Adam Zwolak , Triveni K. Bhatt , Michael Dennis Feldkamp , Sherry Lynn La Porte
Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US20220306739A1
公开(公告)日：2022-09-29
申请号：US17186704
申请日：2021-02-26
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
Abstract: Anti-TRGV9 molecules, such as anti-TRGV9 antibodies or antigen binding fragments thereof, are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US20250092134A1
公开(公告)日：2025-03-20
申请号：US18706417
申请日：2022-11-01
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , IqbaI S. GREWAL , Sanjaya SINGH , Michael Riis HANSEN
IPC: C07K16/28
Abstract: Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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Patent Agency Ranking
公开(公告)号：US20210284730A1
公开(公告)日：2021-09-16
申请号：US17200287
申请日：2021-03-12
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
Abstract: Anti-TRDV2 multispecific antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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7.发明申请公开(公告)号：US20210040210A1
公开(公告)日：2021-02-11
申请号：US16937285
申请日：2020-07-23
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , John Lee , Jinquan Luo , Theresa McDevitt , Fei Shen , Degang Song , Raymond Brittingham , Sathyadevi Venkataramani , Sanjaya Singh , Yonghong Zhao , Fang Yi , Sherry Lynn La Porte
Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
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公开(公告)号：US20210032338A1
公开(公告)日：2021-02-04
申请号：US16869401
申请日：2020-05-07
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
Abstract: Anti-TRGV9 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
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公开(公告)号：US20200231686A1
公开(公告)日：2020-07-23
申请号：US16743188
申请日：2020-01-15
Applicant: Janssen Biotech, Inc.
Inventor： Ricardo Attar , Rajkumar Ganesan , Francois Gaudet , Bradley J. Heidrich , Carmen Baca Jones , John Lee , Yingzhe Li , Sanjaya Singh , Sathya Venkataramani
Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for the treatment of cancer.
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公开(公告)号：US12134658B2
公开(公告)日：2024-11-05
申请号：US17391744
申请日：2021-08-02
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar Ganesan , Adam Zwolak , Ian White , Ninkka Tamot , Paul B. Harvilla , Rajitha Doddareddy , Sanjaya Singh , Martin Jack Borrok, III
Abstract: Provided herein are multispecific molecules comprising a first binding domain that specifically binds to polymeric immunoglobulin receptor (pIgR) and a second binding domain that specifically binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related methods for the treatment of patients infected with SARS-CoV-2.
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