公开(公告)号：US20220064333A1

公开(公告)日：2022-03-03

申请号：US17476683

申请日：2021-09-16

Applicant: Janssen Biotech, Inc.

Inventor： Par Oskar Vilhelmsson Timmermand ,  Amanda Thuy Tran ,  Sven-Erik Strand ,  Urpo Juhani Lamminmaki ,  Kjell Sjostrom

IPC: C07K16/40 ,  C07K16/30 ,  A61K51/10

Abstract: The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer

公开(公告)号：US20220125961A1

公开(公告)日：2022-04-28

申请号：US17570933

申请日：2022-01-07

Applicant: Janssen Biotech, Inc.

Inventor： Sven-Erik Strand ,  Amanda Thuy Tran ,  Sven-Niklas Anders Axelsson

IPC: A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68 ,  A61K49/16 ,  A61K49/22 ,  C07K16/18 ,  C07K16/40

Abstract: The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.

公开(公告)号：US11230609B2

公开(公告)日：2022-01-25

申请号：US16117522

申请日：2018-08-30

Applicant: JANSSEN BIOTECH, INC.

Inventor： Par Oskar Vilhelmsson Timmermand ,  Amanda Thuy Tran ,  Sven-Erik Strand ,  Urpo Juhani Lamminmaki ,  Kjell Sjostrom

IPC: C07K16/40 ,  C07K16/30 ,  A61K51/10 ,  A61K39/00

Abstract: The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2 and SEQ ID NO:3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO:4 and SEQ ID NO:5 and SEQ ID NO:6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.