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1.发明公开公开(公告)号：US20230183233A1
公开(公告)日：2023-06-15
申请号：US17870165
申请日：2022-07-21
发明人： Guozhang Xu , Mark J. Macielag , Micheal D. Gaul , Zhijie Liu
IPC分类号： C07D471/04 , C07D471/10 , C07D487/04
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04
摘要： The present invention is directed to bicyclic pyridinon-2-one and pyrimidin-4-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20230097157A1
公开(公告)日：2023-03-30
申请号：US17870156
申请日：2022-07-21
发明人： Guozhang Xu , Mark J. Macielag , Micheal D. Gaul , Tho V. Thieu , Zhijie Liu
IPC分类号： C07D471/04
摘要： The present invention is directed to bicyclic pyridinon-2-one and pyrimidin-4-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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3.发明申请公开(公告)号：US20230064443A1
公开(公告)日：2023-03-02
申请号：US17870151
申请日：2022-07-21
发明人： Guozhang Xu , Mark J. Macielag
IPC分类号： C07D471/04
摘要： The present invention is directed to 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20220315561A1
公开(公告)日：2022-10-06
申请号：US17696922
申请日：2022-03-17
发明人： Guozhang Xu , Tho V. Thieu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D401/14
摘要： The present invention provides imidazole substituted pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20190367469A1
公开(公告)日：2019-12-05
申请号：US16348304
申请日：2017-11-08
发明人： Micheal Gaul , Gee-Hong Kuo , Guozhang Xu , Yin Liang
IPC分类号： C07D309/10
摘要： The present invention is directed to benzocyclobutane derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity. More particularly, the compounds of the present invention are useful in the treatment of for example, Type II diabetes mellitus, Syndrome X, and complications and symptoms associated with said disorders.
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![Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors](/abs-image/US/2024/04/16/US11958856B2/abs.jpg.150x150.jpg)
6.发明授权公开(公告)号：US11958856B2
公开(公告)日：2024-04-16
申请号：US17870142
申请日：2022-07-21
发明人： Guozhang Xu , Zhijie Liu
IPC分类号： A61K31/55 , A61K9/48 , C07D223/14 , C07D487/04
CPC分类号： C07D487/04 , A61K9/4858
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or stereoisomer thereof:
Pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.-
公开(公告)号：US20220306632A1
公开(公告)日：2022-09-29
申请号：US17696925
申请日：2022-03-17
发明人： Guozhang Xu , Zhijie Liu , Micheal D. Gaul
IPC分类号： C07D471/14 , C07D471/04
摘要： The present invention is directed to bicyclic pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
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公开(公告)号：US20220220125A1
公开(公告)日：2022-07-14
申请号：US17603961
申请日：2020-04-15
发明人： Guozhang Xu
IPC分类号： C07D498/04 , C07D487/04 , C07D471/14
摘要： The present invention is directed to fused isoindolin-1-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GRK2.
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公开(公告)号：US11098016B2
公开(公告)日：2021-08-24
申请号：US16992062
申请日：2020-08-12
发明人： Guozhang Xu , Micheal Gaul , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D409/04 , C07D231/56 , C07D401/06 , C07D405/14 , C07D405/04 , A61K31/416 , C07D403/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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公开(公告)号：US20200377462A1
公开(公告)日：2020-12-03
申请号：US16992062
申请日：2020-08-12
发明人： Guozhang Xu , Micheal Gaul , Shyh-Ming Yang , Tianbao Lu , Rui Zhang , Fengbin Song
IPC分类号： C07D231/56 , C07D401/06 , C07D405/14 , C07D405/04 , C07D409/04 , A61K31/416 , C07D403/04
摘要： The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
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