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公开(公告)号：US20220339123A1
公开(公告)日：2022-10-27
申请号：US17642550
申请日：2020-03-04
发明人： M. Ilias JIMIDAR , Jingli WANG , Caroline AERTS , Katrien VERBRUGGEN , Saartje THEUNIS , Jaskaran SINGH , Kris KAYENS , Peter ZANNIKOS , Hong YAN
IPC分类号： A61K31/135 , A61K9/00 , A61P25/24
摘要： The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.
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公开(公告)号：US20220361758A1
公开(公告)日：2022-11-17
申请号：US17763033
申请日：2020-09-24
发明人： Francesco N. ALBERTINI , Gregory J. BAKOS , Jeffrey DANIEL , Anthony R. DIUBALDI , James A. FLEMING , Jason L. HARRIS , Kevin L. HOUSER , Emma Louise HUBERT , Michael HUTCHINSON , David KALIKHMAN , Monica A. KAPIL , Wouter Jacques Noel LEQUIEU , David RAMOS , Ian SCRIMGEOUR , Frederick E. SHELTON, IV , Jaskaran SINGH , Steven M. VESOLE , Jingli WANG , Hong YAN
摘要： In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.
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公开(公告)号：US20240335398A1
公开(公告)日：2024-10-10
申请号：US18679670
申请日：2024-05-31
发明人： M. Ilias JIMIDAR , Jingli WANG , Caroline AERTS , Katrien VERBRUGGEN , Saartje THEUNIS , Jaskaran SINGH , Kris KAYENS , Peter ZANNIKOS , Hong YAN
IPC分类号： A61K31/135 , A61K9/00 , A61M11/00 , A61P25/24
CPC分类号： A61K31/135 , A61K9/0043 , A61P25/24 , A61M11/001
摘要： The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.
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公开(公告)号：US20230121313A1
公开(公告)日：2023-04-20
申请号：US17890039
申请日：2022-08-17
发明人： M. Ilias JIMIDAR , Jingli WANG , Caroline AERTS , Katrien VERBRUGGEN , Saartje THEUNIS , Jaskaran SINGH , Kris KAYENS , Peter ZANNIKOS , Hong YAN
IPC分类号： A61K31/135 , A61P25/24 , A61K9/00
摘要： The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.
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公开(公告)号：US20220336076A1
公开(公告)日：2022-10-20
申请号：US17763600
申请日：2020-09-24
发明人： Francesco N. ALBERTINI , Gregory J. BAKOS , Anthony R. DIUBALDI , Jason L. HARRIS , Emma Louise HUBERT , Michael HUTCHINSON , David KALIKHMAN , Monica A. KAPIL , Peter KRULEVITCH , Wouter Jacques Noel LEQUIEU , Frederick E. SHELTON, IV , Jaskaran SINGH , George SZABO , Steven M. VESOLE , Jingli WANG
摘要： The present disclosure relates to drug administration. In an exemplary embodiment, a system can include a drug administration device configured to dispense a drug to a patient, a monitoring device configured to log a delivery event of drug delivery from the drug administration device into the patient, and a sensor configured to sense a patient parameter following delivery of the drug into the patient. In another exemplary embodiment, a drug administration device can include a drug holder configured to hold a drug, a dispensing mechanism configured to dispense the drug, and a sensor configured to sense a patient parameter, and the drug administration device can be configured to locally activate the drug at a target location in the patient. In another exemplary embodiment, methods, devices, and systems are provided to assess when operation of a drug dispensing mechanism is complete and to confirm whether drug administration was successful.
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公开(公告)号：US20240226464A1
公开(公告)日：2024-07-11
申请号：US17763585
申请日：2020-09-24
发明人： Francesco N. ALBERTINI , Gregory J. BAKOS , Michael A. BARATTA , Michael CANNAMELA , Anthony R. DIUBALDI , Yueheng DOU , Wayne DREVETS , James A. FLEMING , Jason L. HARRIS , Kevin L. HOUSER , Emma Louise HUBERT , Michael HUTCHINSON , Monica A. KAPIL , Peter KRULEVITCH , Chaley John LARSON , Wouter Jacques Noel LEQUIEU , Kui LIU, IV , Frederick E. SHELTON, IV , George SZABO , Steven M. VESOLE , Jingli WANG , Hong YAN
CPC分类号： A61M15/0003 , A61M15/0066 , G06T7/00 , A61M2205/52 , A61M2230/201 , A61M2230/30 , A61M2230/50
摘要： Provided herein are drug administration devices, methods, and systems for adjusting drug delivery to a patient to allow drug dosage to be adjusted based on a variety of different factors influencing the patient during administration of the drug. In one embodiment, a drug administration device or system can have a drug holder with a drug therein to be delivered to a patient, one or more sensors that are configured to gather various data associated with the patient, and at least one processor that can analyze the data gathered by the one or more sensors and adjust delivery of the drug based on the data.
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公开(公告)号：US20220409127A1
公开(公告)日：2022-12-29
申请号：US17762901
申请日：2020-09-24
发明人： Francesco N. ALBERTINI , Michael A. BARATTA , Jason L. HARRIS , Emma Louise HUBERT , Michael HUTCHINSON , David KALIKHMAN , Monica A. KAPIL , Peter KRULEVITCH , Shagun POPLI , Frederick E. Shelton, IV , Jaskaran SINGH , Jingli WANG
摘要： In general, methods, systems, and devices for remote aggregation of data for drug administration devices are provided. In one exemplary embodiment, data indicative of information sensed with a sensor of a drug administration device can be wirelessly transmitted from a drug administration device to a server. The server can use the data to correlate the patients use of the drug with the patients clinical outcome, perform a cost analysis of the patients treatment, determine whether the drug was delivered to the patient in compliance with the patients treatment plan, identify a malfunction in the administration of the drug, determine that additional data is needed from the drug administration device and trigger a request for the additional data to be wirelessly transmitted from the server to the drug administration device, and/or predictively model the patients clinical outcome.
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