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1.发明申请公开(公告)号：US20180127361A1
公开(公告)日：2018-05-10
申请号：US15681309
申请日：2017-08-18
发明人： Koen VANDYCK , Stefaan Julien LAST , Geert ROMBOUTS , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07C311/37 , C07C311/14 , C07D205/04 , A61K45/06 , A61K31/401 , A61K31/495 , C07D233/84 , A61K31/34 , A61K31/397 , C07D309/14 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D307/68 , C07D295/26 , C07D211/76 , C07D211/56 , C07D295/13 , C07D211/28 , C07D277/56 , C07D207/36 , C07D493/08 , C07D207/14 , C07D491/107 , C07D233/90 , C07D333/48 , C07D333/38 , C07D213/82 , C07D213/81 , C07D307/22 , C07D305/08 , C07D211/96 , C07C311/51 , C07C311/20 , C07C311/16 , A61K31/4468 , A61K31/4453 , A61K31/44 , A61K31/426 , A61K31/4164 , A61K31/351 , A61K31/341 , A61K31/337 , A61K31/18 , C07D307/60 , C07D213/42 , C07D207/273
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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2.发明申请公开(公告)号：US20180153857A1
公开(公告)日：2018-06-07
申请号：US15886766
申请日：2018-02-01
发明人： Koen VANDYCK , Geerwin Yvonne Paul HACHÉ , Stefaan Julien LAST , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： A61K31/40 , A61K31/403 , C07D487/08 , C07D491/107 , A61K31/404 , A61K31/407 , A61K31/4025 , A61K45/06 , C07D207/16 , C07D207/48 , C07D209/42 , C07D209/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D487/04
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/407 , A61K45/06 , C07D207/16 , C07D207/48 , C07D209/42 , C07D209/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D487/04 , C07D487/08 , C07D491/107
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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3.发明申请公开(公告)号：US20180141905A1
公开(公告)日：2018-05-24
申请号：US15875929
申请日：2018-01-19
发明人： Koen VANDYCK , Geerwin Yvonne Paul HACHÉ , Stefaan Julien LAST , David Craig MCGOWAN , Geert ROMBOUTS , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D207/36 , C07D403/12 , C07D405/12 , C07D207/40 , A61K45/06 , A61K31/401
摘要： Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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4.发明申请公开(公告)号：US20200039931A1
公开(公告)日：2020-02-06
申请号：US16601396
申请日：2019-10-14
发明人： Koen VANDYCK , Geerwin Yvonne Paul HACHÉ , Stefaan Julien LAST , David Craig MCGOWAN , Geert ROMBOUTS , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D207/36 , A61K45/06 , A61K31/401 , C07D207/40 , C07D403/12 , C07D405/12
摘要： Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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![PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES](/abs-image/US/2016/06/16/US20160168150A1/abs.jpg.150x150.jpg)
5.发明申请PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES 审中-公开PYRROLO [3,2-D]吡嗪衍生物用于治疗病毒感染和其他疾病公开(公告)号：US20160168150A1
公开(公告)日：2016-06-16
申请号：US14392214
申请日：2014-06-26
发明人： David Craig MC GOWAN , Serge Maria Aloysius PIETERS , Stefaan Julien LAST , Werner EMBRECHTS , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
摘要翻译： 本发明涉及吡咯并[3,2-d]嘧啶衍生物，其制备方法，药物组合物及其在治疗和/或治疗疾病中的用途。
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6.发明申请SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开磺酰胆碱衍生物及其用作治疗乙型肝炎的药物公开(公告)号：US20160115149A1
公开(公告)日：2016-04-28
申请号：US14891895
申请日：2014-05-16
发明人： Koen VANDYCK , Geerwin Yvonne Paul HACHÉ , Stefaan Julien LAST , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D333/38 , C07D409/12
CPC分类号： C07D333/38 , C07D409/12
摘要： Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R8 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 包含立体化学异构形式的式（I）的HBV复制抑制剂及其盐，水合物，溶剂合物，其中X和R 1至R 8具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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7.发明申请SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 有权磺酰吡咯烷酮衍生物及其作为治疗乙型肝炎的药物的用途公开(公告)号：US20160115125A1
公开(公告)日：2016-04-28
申请号：US14891864
申请日：2014-05-16
发明人： Koen VANDYCK , Geerwin Yvonne Paul HACHÉ , Stefaan Julien LAST , David Craig MC GOWAN , Geert ROMBOUTS , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D207/36 , C07D403/12 , C07D405/12
CPC分类号： C07D207/36 , A61K31/401 , A61K45/06 , C07D207/40 , C07D403/12 , C07D405/12 , A61K2300/00
摘要： Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 包括立体化学异构形式的式（ID）的HBV复制抑制剂及其盐，水合物，溶剂化物，其中X，Ra至Rd和R4至R6具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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8.发明申请公开(公告)号：US20200255373A1
公开(公告)日：2020-08-13
申请号：US16858519
申请日：2020-04-24
发明人： Koen VANDYCK , Stefaan Julien LAST , Geert ROMBOUTS , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07C311/37 , C07C311/14 , A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/4164 , A61K31/426 , A61K31/44 , A61K31/4453 , A61K31/4468 , C07C311/16 , C07C311/20 , C07C311/51 , C07D211/96 , C07D305/08 , C07D307/22 , C07D205/04 , C07D207/273 , C07D213/42 , C07D307/60 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/48 , C07D233/90 , C07D491/107 , C07D207/14 , C07D207/36 , C07D277/56 , C07D211/28 , C07D295/13 , C07D211/56 , C07D211/76 , C07D295/26 , C07D307/68 , C07D493/08 , A61K31/34 , A61K31/397 , A61K31/495 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D233/84 , C07D309/14 , A61K31/401 , A61K45/06
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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9.发明申请公开(公告)号：US20170349557A1
公开(公告)日：2017-12-07
申请号：US15591473
申请日：2017-05-10
发明人： Stefaan Julien LAST , David Craig MC GOWAN , Werner EMBRECHTS , Serge Maria Aloysius PIETERS , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D239/84 , C07D403/12 , C07D239/95 , C07D401/12 , C07D417/12 , C07D413/12
CPC分类号： C07D239/84 , C07D239/95 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
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10.发明申请CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开循环磺酰氨酰胺衍生物及其作为治疗乙型肝炎的药物的用途公开(公告)号：US20170002025A1
公开(公告)日：2017-01-05
申请号：US15195809
申请日：2016-06-28
发明人： Sandrine Marie Helene VENDEVILLE , Stefaan Julien LAST , Samuël Dominique DEMIN , Sandrine Céline GROSSE , Geerwin Yvonne Paul HACHÉ , Lili HU , Serge Maria Aloysius PIETERS , Geert ROMBOUTS , Koen VANDYCK , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D513/04 , A61K31/407 , C07D515/20 , A61K31/542 , C07D515/04 , C07D515/10 , A61K45/06 , A61K31/554
摘要： Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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