公开(公告)号：US10046065B2

公开(公告)日：2018-08-14

申请号：US14909162

申请日：2014-08-05

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Kazunori Kataoka ,  Kensuke Osada ,  Theofilus Agrios Tockary

IPC: B01L3/00 ,  C12Q1/04 ,  C12Q1/68 ,  A61K48/00 ,  A61K47/34 ,  A61K9/00 ,  A61K9/107 ,  C12N15/88 ,  A61K31/711 ,  A61K31/713

Abstract: A nucleic acid-encapsulating polymer micelle complex is formed of a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polymer chain block; and two single-stranded DNA molecules having mutually complementary base sequences of 1000 or more bases in length, double-stranded DNA of 1000 or more base pairs in length in which at least a part of a double helix structure is dissociated and forms a single-stranded structure, or one single-stranded DNA molecule of 1000 or more bases in length.