公开(公告)号：US20240325521A1

公开(公告)日：2024-10-03

申请号：US18576244

申请日：2022-05-10

申请人： JENKEM TECHNOLOGY CO., LTD.(TIANJIN) ,  CANSINO (SHANGHAI) BIOLOGICAL RESEARCH CO., LTD.

发明人： Jing HAO ,  Qingbin WANG ,  Shengyong YAN ,  Haomeng WANG ,  Zhihong YAN ,  Jian LIU ,  Xuefeng YU ,  Dongxu Qiu ,  Meina LIN ,  Jun GUO ,  Yanli XIONG ,  Tao ZHU ,  Xuan ZHAO

IPC分类号： A61K39/215 ,  A61K9/127 ,  A61K39/00 ,  C07C215/14 ,  C07C229/12 ,  C07C233/36

CPC分类号： A61K39/215 ,  A61K9/1272 ,  C07C215/14 ,  C07C229/12 ,  C07C233/36 ,  A61K2039/53

摘要： Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiency and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.