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公开(公告)号：US09707205B2
公开(公告)日：2017-07-18
申请号：US14920780
申请日：2015-10-22
发明人： Gurmit S. Gill , Damian W. Grobelny
IPC分类号： A61K31/00 , A61K31/343 , A61K31/16 , A61K31/18 , A61K31/382 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/4164 , C07C33/26 , C07C215/10 , C07C215/14 , C07C215/16 , C07C229/16 , C07C275/24 , C07C275/28 , C07C281/06 , C07D205/04 , C07D209/04 , C07D209/08 , C07D215/18 , C07D233/32 , C07D241/12 , C07D257/04 , C07D295/104 , C07D307/79 , C07D307/81 , C07D311/22 , C07D333/04 , C07D333/20 , C07D413/10 , C07D413/14 , C07F9/09 , C07F9/6558 , C07D413/04 , A61K31/4245
CPC分类号： A61K31/343 , A61K31/16 , A61K31/18 , A61K31/382 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/4164 , A61K31/4245 , C07C33/26 , C07C215/10 , C07C215/14 , C07C215/16 , C07C229/16 , C07C275/24 , C07C275/28 , C07C281/06 , C07C2602/42 , C07C2603/74 , C07D205/04 , C07D209/04 , C07D209/08 , C07D215/18 , C07D233/32 , C07D241/12 , C07D257/04 , C07D295/104 , C07D307/79 , C07D307/81 , C07D311/22 , C07D333/04 , C07D333/20 , C07D413/04 , C07D413/10 , C07D413/14 , C07F9/094 , C07F9/65586 , Y02A50/402 , Y02A50/47
摘要： The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.
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公开(公告)号：US09691517B2
公开(公告)日：2017-06-27
申请号：US14701837
申请日：2015-05-01
IPC分类号： H01B1/12 , C08G18/32 , C07C215/10 , C07C215/12 , C07C215/14 , C07C215/18 , C07C311/09 , C07C311/32 , C08G18/48 , C08G18/08 , C07C215/40 , C07D213/04 , C07D207/06 , C07C217/08 , C07D285/15 , C07D233/61 , C07C311/48 , C08G18/38 , C08G18/76
CPC分类号： H01B1/122 , C07C215/10 , C07C215/12 , C07C215/14 , C07C215/18 , C07C215/40 , C07C217/08 , C07C311/09 , C07C311/32 , C07C311/48 , C07D207/06 , C07D213/04 , C07D233/61 , C07D285/15 , C08G18/0814 , C08G18/3275 , C08G18/3278 , C08G18/3281 , C08G18/3284 , C08G18/3861 , C08G18/48 , C08G18/7671 , H01B1/125
摘要： Provided are a hydroxy compound and an ion conducting agent each having excellent electroconductivity. Also provided is an electroconductive resin composition suppressed in bleeding and excellent in electroconductivity through the use of the hydroxy compound. Specifically, provided are a hydroxy compound represented by the following general formula (1), and an ion conducting agent including the hydroxy compound.
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3.发明授权公开(公告)号：US09604900B2
公开(公告)日：2017-03-28
申请号：US14111157
申请日：2012-04-13
IPC分类号： A01N43/16 , A61K31/35 , C07D311/00 , C07C57/38 , C07C59/66 , C07D215/14 , C07D311/58 , C07D405/04 , C07D407/04 , A61K31/192 , A61K31/352 , A61K31/473 , C07C215/14 , A61K31/353 , A61K31/357 , A61K31/47 , A61K31/4709 , A61K31/553 , A61K45/06 , C07D215/54 , C07D311/74 , C07D413/04
CPC分类号： C07C57/38 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/553 , A61K45/06 , C07C59/66 , C07C215/14 , C07D215/14 , C07D215/54 , C07D311/58 , C07D311/74 , C07D405/04 , C07D407/04 , C07D413/04
摘要： The present invention relates to aromatic carbocycle or heterocycle compounds comprising an acid function and being of formula (5), wherein W, Q1, Q2, Q3, Q4, R1, R3, R4, R7, R9, R11, a, c, e, and g are as described in the description; and the use of such compounds in the treatment or the prevention of viral disorders, including HIV.
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公开(公告)号：US09403767B2
公开(公告)日：2016-08-02
申请号：US13803295
申请日：2013-03-14
申请人： Grünenthal GmbH
发明人： Bert Nolte , Wolfgang Schröder , Klaus Linz , Werner Englberger , Hans Schick , Heinz Graubaum , Birgit Braun , Sigrid Ozegowski , József Bálint , Helmut Sonnenschein
IPC分类号： C07C211/00 , C07D209/20 , C07C211/40 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C275/24 , C07C311/07 , C07C311/18 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08 , A61K31/135 , A61K45/06 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , C07C211/54 , C07C237/24 , C07C311/37 , C07D251/48
CPC分类号： C07D209/20 , A61K31/135 , A61K31/136 , A61K31/165 , A61K31/18 , A61K31/404 , A61K31/53 , A61K31/5377 , A61K45/06 , C07C211/40 , C07C211/54 , C07C215/14 , C07C215/42 , C07C217/74 , C07C223/04 , C07C229/16 , C07C233/36 , C07C233/40 , C07C233/41 , C07C233/62 , C07C233/79 , C07C235/54 , C07C237/06 , C07C237/24 , C07C275/24 , C07C311/07 , C07C311/18 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/12 , C07D209/14 , C07D211/62 , C07D213/12 , C07D213/82 , C07D231/14 , C07D251/48 , C07D251/54 , C07D295/135 , C07D309/08 , C07D333/20 , C07D403/08 , C07D409/08
摘要： The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
摘要翻译： 本发明涉及对μ-阿片受体和ORL1-受体具有亲和力的化合物，其生产方法，含有这些化合物的药物以及这些化合物用于治疗疼痛和其它病症的用途。
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公开(公告)号：US20160038455A1
公开(公告)日：2016-02-11
申请号：US14920780
申请日：2015-10-22
发明人： GURMIT S. GILL , DAMIAN W. GROBELNY
IPC分类号： A61K31/343 , A61K31/4245
CPC分类号： A61K31/343 , A61K31/16 , A61K31/18 , A61K31/382 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/4164 , A61K31/4245 , C07C33/26 , C07C215/10 , C07C215/14 , C07C215/16 , C07C229/16 , C07C275/24 , C07C275/28 , C07C281/06 , C07C2602/42 , C07C2603/74 , C07D205/04 , C07D209/04 , C07D209/08 , C07D215/18 , C07D233/32 , C07D241/12 , C07D257/04 , C07D295/104 , C07D307/79 , C07D307/81 , C07D311/22 , C07D333/04 , C07D333/20 , C07D413/04 , C07D413/10 , C07D413/14 , C07F9/094 , C07F9/65586 , Y02A50/402 , Y02A50/47
摘要： The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.
摘要翻译： 本发明涉及具有S1P受体调节活性的新化合物。 此外，本发明涉及包含至少一种本发明化合物的药物，其用于治疗由不适当的S1P受体调节活性或表达引起或与之相关的疾病和/或症状，例如自身免疫应答。 本发明的另一方面涉及包含至少一种本发明化合物的药物在制备用于治疗由不适当的S1P受体调节活性或表达引起或与之相关的疾病和/或症状的药物的用途，例如 自身免疫反应。
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公开(公告)号：US09193716B2
公开(公告)日：2015-11-24
申请号：US14066276
申请日：2013-10-29
发明人： Gurmit S. Gill , Damian W. Grobelny
IPC分类号： A61K31/00 , C07D413/04 , A61K31/16 , A61K31/18 , A61K31/343 , A61K31/382 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/4164 , C07C33/26 , C07C215/10 , C07C215/14 , C07C215/16 , C07C229/16 , C07C275/24 , C07C275/28 , C07C281/06 , C07D205/04 , C07D209/04 , C07D209/08 , C07D215/18 , C07D233/32 , C07D241/12 , C07D257/04 , C07D295/104 , C07D307/79 , C07D307/81 , C07D311/22 , C07D333/04 , C07D333/20 , C07D413/10 , C07D413/14 , C07F9/09 , C07F9/6558
CPC分类号： A61K31/343 , A61K31/16 , A61K31/18 , A61K31/382 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/4164 , A61K31/4245 , C07C33/26 , C07C215/10 , C07C215/14 , C07C215/16 , C07C229/16 , C07C275/24 , C07C275/28 , C07C281/06 , C07C2602/42 , C07C2603/74 , C07D205/04 , C07D209/04 , C07D209/08 , C07D215/18 , C07D233/32 , C07D241/12 , C07D257/04 , C07D295/104 , C07D307/79 , C07D307/81 , C07D311/22 , C07D333/04 , C07D333/20 , C07D413/04 , C07D413/10 , C07D413/14 , C07F9/094 , C07F9/65586 , Y02A50/402 , Y02A50/47
摘要： The invention relates to novel compounds that have SIP receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate SIP receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate SIP receptor modulating activity or expression such as autoimmune response.
摘要翻译： 本发明涉及具有SIP受体调节活性的新化合物。 此外，本发明涉及包含至少一种本发明化合物的药物，其用于治疗由不适当的SIP受体调节活性或表达引起或与之相关的疾病和/或症状，例如自身免疫应答。 本发明的另一方面涉及包含至少一种本发明化合物的药物在制备用于治疗由不适当的SIP受体调节活性或表达引起或与之相关的疾病和/或症状的药物的用途，例如 自身免疫反应。
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公开(公告)号：US20140187678A1
公开(公告)日：2014-07-03
申请号：US14197255
申请日：2014-03-05
申请人： Ian A. Tomlinson , Asghar A. Peera
发明人： Ian A. Tomlinson , Asghar A. Peera
IPC分类号： C09D7/12
CPC分类号： C09D7/1233 , C07C215/14 , C08K5/17 , C09D5/024 , C09D7/63
摘要： Provided are polyhydroxy-diamine compounds of the formula I: or salt thereof, wherein R1, R2, and R3 are as defined herein. The compounds are useful as low additives for paints, coatings and epoxy formulations.
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公开(公告)号：US08702859B2
公开(公告)日：2014-04-22
申请号：US13263470
申请日：2010-04-28
申请人： Ian A. Tomlinson , Asghar A. Peera
发明人： Ian A. Tomlinson , Asghar A. Peera
CPC分类号： C09D7/1233 , C07C215/14 , C08K5/17 , C09D5/024 , C09D7/63
摘要： Provided are polyhydroxy-diamine compounds of the formula I: or salt thereof, wherein R1, R2, and R3 are as defined herein. The compounds are useful as low additives for paints, coatings and epoxy formulations.
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公开(公告)号：US08697834B2
公开(公告)日：2014-04-15
申请号：US13116649
申请日：2011-05-26
申请人： Thomas Schaub , Boris Buschhaus , Johann-Peter Melder , Rocco Paciello , Stephan Hüffer , Helmut Witteler
发明人： Thomas Schaub , Boris Buschhaus , Johann-Peter Melder , Rocco Paciello , Stephan Hüffer , Helmut Witteler
CPC分类号： C07C209/16 , C07C213/02 , C08G73/0213 , C07C211/14 , C07C215/14
摘要： The invention relates to a process for the preparation of polyalkylenepolyamines by catalyzed alcohol amination, in which(i) aliphatic aminoalcohols are reacted with one another or(ii) aliphatic diamines or polyamines are reacted with aliphatic diols or polyols with the elimination of water in the presence of a catalyst.
摘要翻译： 本发明涉及通过催化醇胺化制备聚亚烷基多胺的方法，其中（i）脂肪族氨基醇彼此反应，或（ii）脂族二胺或多胺与脂族二元醇或多元醇反应，在 存在催化剂。
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10.发明授权公开(公告)号：US08480800B2
公开(公告)日：2013-07-09
申请号：US12957958
申请日：2010-12-01
IPC分类号： C07D303/36 , C07D301/03 , C07C213/02
CPC分类号： C07D303/08 , C07C215/08 , C07C215/14 , C07C215/42 , C08K5/17 , C09D5/024 , C09D7/63
摘要： Provided are aminoalcohol compounds for use as neutralizing agents for paints and coatings. The compounds are of the formula (I): or salt thereof, wherein R1, R2, R3, R4, R5, and n are as defined herein. Also provided are precursors of the aminoalcohol compounds and processes for making and using them.
摘要翻译： 提供用作油漆和涂料中和剂的氨基醇化合物。 所述化合物具有式（I）：或其盐，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。 还提供了氨基醇化合物的前体和其制备和使用方法。
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