公开(公告)号：US11478552B2

公开(公告)日：2022-10-25

申请号：US16308632

申请日：2017-06-09

申请人： CureVac AG

发明人： Patrick Baumhof ,  Carolin Thiele ,  Joanna Rejman

IPC分类号： A61K47/64 ,  A61K47/69 ,  A61K48/00 ,  C07C215/14 ,  C07C233/56 ,  C07C237/12 ,  A61K9/00

摘要： A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of the lipidoid in the composition is preferably low, relative to the cationic peptide or polymer.

公开(公告)号：US20210387941A1

公开(公告)日：2021-12-16

申请号：US17288946

申请日：2019-10-25

申请人： SHANGHAI MAXINOVEL PHARMACEUTICALS CO., LTD.

发明人： Yuguang WANG ,  Nong ZHANG ,  Tianzhi WU ,  Min HE

IPC分类号： C07C229/22 ,  C07C223/02 ,  C07C215/14 ,  C07C227/16 ,  C07C213/08 ,  C07C47/55

摘要： The present invention provides a diphenyl-like compound, and intermediate thereof, a preparation method therefor, a pharmaceutical composition thereof and the uses thereof. According to the invention, the diphenyl-like compound has a significant inhibitory effect on PD-1 and/or PD-L1, and can effectively alleviate or treat related diseases such as cancer.

公开(公告)号：US20210101875A1

公开(公告)日：2021-04-08

申请号：US17070486

申请日：2020-10-14

申请人： Massachusetts Institute of Technology

发明人： Kerry Peter Mahon ,  Kevin Thomas Love ,  Christopher G. Levins ,  Kathryn Ann Whitehead ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC分类号： C07D295/13 ,  A61K9/127 ,  A61K9/51 ,  A61K47/16 ,  A61K48/00 ,  C07C215/14 ,  C12N15/11 ,  C12N15/88 ,  A61K47/54 ,  C07C217/08 ,  A61K31/7088 ,  A61K38/02 ,  A61K9/107 ,  C12N15/113

摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

公开(公告)号：US10106494B2

公开(公告)日：2018-10-23

申请号：US15101396

申请日：2013-12-02

申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC

发明人： Georgius Abidal Adam

IPC分类号： C07C211/09 ,  C07C211/63 ,  C07C215/14 ,  C07C215/40 ,  C07C229/16 ,  C07C273/18 ,  C07C275/14 ,  C07C275/46 ,  C07C275/62 ,  C07C271/54 ,  C07C213/06 ,  C07C217/54 ,  C07D251/70

摘要： Disclosed herein are gemini surfactants, and methods for making and using these gemini surfactants. These gemini surfactants may be incorporated in paints and coatings to provide hydrophilic and/or self-cleaning properties.

公开(公告)号：US20180223213A1

公开(公告)日：2018-08-09

申请号：US15562339

申请日：2016-03-31

申请人： FUNDACIÓN CIDETEC

发明人： Ignacio GARCÍA ALONSO ,  Sarah MONTES PÉREZ ,  Ibon ODRIOZOLA ,  Germán CABAÑERO ,  Hans-Jürgen GRANDE ,  Ramón TENA ZAERA

IPC分类号： C10M125/22 ,  C07C43/13 ,  C07C41/18 ,  C07C31/20 ,  C07C29/00 ,  C07C215/14 ,  C07C213/08 ,  C08G65/326 ,  C07C215/08 ,  C07C321/04 ,  C07C319/12 ,  C08K7/14 ,  C08K9/04 ,  C08K9/08 ,  C08K3/30 ,  C10M159/18 ,  C01G39/06

CPC分类号： C10M125/22 ,  C01B19/007 ,  C01G39/06 ,  C01G41/00 ,  C01P2002/82 ,  C01P2002/88 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/10 ,  C01P2004/13 ,  C01P2004/16 ,  C01P2004/24 ,  C01P2004/32 ,  C01P2004/62 ,  C01P2004/64 ,  C07C29/00 ,  C07C31/20 ,  C07C31/205 ,  C07C41/18 ,  C07C43/132 ,  C07C213/08 ,  C07C215/08 ,  C07C215/14 ,  C07C319/12 ,  C07C321/04 ,  C08G65/326 ,  C08K3/30 ,  C08K7/14 ,  C08K9/04 ,  C08K9/08 ,  C08K2003/3009 ,  C08K2201/011 ,  C10M159/18 ,  C10M2201/065 ,  C10M2201/066 ,  C10M2227/066 ,  C10M2227/09 ,  C10N2210/06 ,  C10N2220/082 ,  C10N2230/06

摘要： The present invention provides a Molybdenum or Tungsten chalcogenide nanoobject having: (a) an object size comprised from 0.1 to 500 nm, and (b) from 1 to 99% by weight of molecules of formula (I) with respect to the total weight of the nanoobject, wherein: A is —OH; X is selected from: (C1-C20)alkyl optionally substituted with one or more radicals; a 2 to 20-member heteroalkyl optionally substituted with one or more radicals; and a homopolymer or copolymer comprising a polymeric chain; B is selected from: H, —OH, —NH2, (C1-C4)alkyl, halogen, phenyl substituted with one or more halogen radicals, benzyl substituted with one or more halogen radicals, —C(═O)R3, —C(═O)(R7), —OC(═O)(O)R3, —C(═O)(O−), —C(═O)(O)R3, —OR3, —CH(OR3)(OR4), —C(OR3)(OR4)(R5), —C(OR3)(OR4)(OR5), —C(OR3)(OR4)(OR5)(OR6), —NR1R2, —N+R1R2R3, —C(═NR1)(R2), —C(═O)(NR1R2), —N(C(═O)(R1)) (C(═O)(R2))(R3), —O(CN), —NC(═O), —ONO2, —CN, —NC, —ON(═O), —NO2, —NO, —C5H4N, —SR1, —SSR1, —S(═O)(R1), — S(═O)(═O)(R1), —S(═O)(OH), —S(═O)(═O)(OH), —SCN, —NCS, —C(═S)(R1), —PR1R2, —P(═O)(OH)2, —OP(═O)(OH)2, —OP(═O)(OR1)(OR2), —B(OH), —B(OR1)(OR2), and —B(OR1)(R2); provided that when B is —H or (C1-C4) alkyl, then X is a homopolymer, a copolymer, or a 2 to 20-member heteroalkyl optionally substituted with one or more radicals as defined above.The present invention also provides processes for the preparation of the nanoobjects, their use as additive for reducing the friction coefficient of a material, and compositions comprising thereof. A-X-B  (I)

公开(公告)号：US09713788B2

公开(公告)日：2017-07-25

申请号：US14885214

申请日：2015-10-16

申请人： David Charles Calabro ,  Lisa Saunders Baugh ,  Pavel Kortunov ,  Benjamin A. McCool ,  Michael Siskin ,  Dennis George Peiffer ,  Quanchang Li

发明人： David Charles Calabro ,  Lisa Saunders Baugh ,  Pavel Kortunov ,  Benjamin A. McCool ,  Michael Siskin ,  Dennis George Peiffer ,  Quanchang Li

IPC分类号： C07C215/18 ,  C07C215/12 ,  C07C215/14 ,  C07C211/14 ,  B01D53/14 ,  B01D53/62

CPC分类号： B01D53/1493 ,  B01D53/1475 ,  B01D53/62 ,  B01D2252/20415 ,  B01D2252/20421 ,  B01D2252/20426 ,  B01D2252/20431 ,  B01D2252/20478 ,  B01D2252/2056 ,  B01D2252/30 ,  Y02A50/2342 ,  Y02C10/04 ,  Y02C10/06

摘要： A method is described for separating CO2 and/or H2S from a mixed gas stream by contacting the gas stream with a non-aqueous, liquid absorbent medium of a primary and/or secondary aliphatic amine, preferably in a non-aqueous, polar, aprotic solvent under conditions sufficient for sorption of at least some of the CO2. The solution containing the absorbed CO2 can then be treated to desorb the acid gas. The method is usually operated as a continuous cyclic sorption-desorption process, with the sorption being carried out in a sorption zone where a circulating stream of the liquid absorbent contacts the gas stream to form a CO2-rich sorbed solution, which is then cycled to a regeneration zone for desorption of the CO2 (advantageously at 0.5:1 (approaching 1:1) may be achieved.

公开(公告)号：US09556109B1

公开(公告)日：2017-01-31

申请号：US15225522

申请日：2016-08-01

申请人： James Madison Innovations, Inc.

发明人： Kevin L. Caran ,  Kyle Seifert

IPC分类号： C07C215/14 ,  A01N33/12

CPC分类号： A01N33/12 ,  C07C215/40

摘要： The inventive subject matter relates to compounds of Formula I, compositions thereof, and processes for making such compounds as further described herein. The inventive compounds and compositions have antimicrobial properties and are useful as environmental disinfectants, topical cleansers such as topical personal care compositions, sanitizers, preservatives, in water treatment, as permanent or erodible coatings for medical devices and appliances, and in therapeutics. Additionally, the compounds of Formula I will serve as synthetic intermediates for making additional novel derivatives of triscationic amphiphile compounds.

摘要翻译： 本发明主题涉及式I化合物，其组合物，以及制备本文进一步描述的化合物的方法。 本发明的化合物和组合物具有抗微生物性质，并且可用作环境消毒剂，局部清洁剂如局部个人护理组合物，消毒剂，防腐剂，在水处理中，作为用于医疗设备和器具的永久或可蚀刻涂层以及治疗剂。 此外，式I的化合物将用作制备三阳离子两亲物化合物的其它新衍生物的合成中间体。

公开(公告)号：US08829145B2

公开(公告)日：2014-09-09

申请号：US12665377

申请日：2008-06-16

申请人： Arran Alexander Dickon Tulloch ,  David Jenkins ,  Joseph Atkinson ,  Mark Alexander Kent ,  Alan Cooper

发明人： Arran Alexander Dickon Tulloch ,  David Jenkins ,  Joseph Atkinson ,  Mark Alexander Kent ,  Alan Cooper

IPC分类号： C08G18/22 ,  B01J31/12 ,  C07C215/14 ,  C07F7/00 ,  C08G18/10 ,  C08G18/12 ,  C08G18/08 ,  C08G101/00

CPC分类号： C07F7/003 ,  B01J2531/0238 ,  B01J2531/46 ,  C07C215/14 ,  C08G18/0885 ,  C08G18/10 ,  C08G18/12 ,  C08G18/222 ,  C08G2101/0083 ,  C08G18/6674

摘要： A method of manufacturing a polyurethane compound comprises mixing together a polyol, a polyisocyanate compound and a catalyst and allowing the mixture to cure to form a polyurethane, and is characterized in that the catalyst is a neutral complex of a metal selected from Ti, Zr, Hf, Al, Fe, Bi or Sn and a multidentate organic ligand having: a) a number of anionic donor sites=x; b) a number of neutral donor sites, capable of forming a co-ordinate bond with the metal, =y; c) where x+y=from 5 to 8; d) x is from 2 to 4; e) the ligand molecule is of a size and conformation to enable each of the anionic donor sites and neutral donor sites to form a bond with the same metal atom.

摘要翻译： 制备聚氨酯化合物的方法包括将多元醇，多异氰酸酯化合物和催化剂混合在一起，并使混合物固化形成聚氨酯，其特征在于催化剂是选自Ti，Zr， Hf，Al，Fe，Bi或Sn和多齿有机配体，其具有：a）多个阴离子供体位点= x; b）能够与金属形成坐标键的许多中性供体位点= y; c）其中x + y = 5至8; d）x为2至4; e）配体分子的大小和构象使得阴离子供体位点和中间供体位点中的每一个能够与相同的金属原子形成键。

公开(公告)号：US08741807B2

公开(公告)日：2014-06-03

申请号：US13402947

申请日：2012-02-23

申请人： Tadao Asami ,  Masashi Hikosaka ,  Masaki Mori ,  Satoru Maeda ,  Fumio Matsuda ,  Kazuki Saito

发明人： Tadao Asami ,  Masashi Hikosaka ,  Masaki Mori ,  Satoru Maeda ,  Fumio Matsuda ,  Kazuki Saito

IPC分类号： A01N25/32 ,  A01N31/02 ,  A01N33/04 ,  C07C211/14 ,  C07C215/14 ,  C07C217/04 ,  C07C217/42 ,  C07C223/02

CPC分类号： C07C225/16 ,  A01N37/20 ,  A01N37/36 ,  C07C225/06 ,  C07C225/14 ,  C07C233/36 ,  C07C233/40 ,  C07C233/78 ,  C07C235/10 ,  Y02P20/55

摘要： A compound useful as a plant activator for activating an endogenous defense system of a plant to control disease damage is provided. A compound represented by the formula: (R3)NH—(CH2)4—N(R1)—(CH2)3—NH(R2) (one of R1 and R2 represents a linear C6-18 alkanoyl group or alkenoyl group, the other represents hydrogen atom or a protective group of amino group; and R3 represents hydrogen atom or a protective group of amino group).

摘要翻译： 提供了可用作植物激活剂激活植物的内源性防御系统以控制疾病损害的化合物。 由式（R3）NH-（CH2）4-N（R1） - （CH2）3-NH（R2）表示的化合物（R1和R2之一表示直链C 18-18烷酰基或烯酰基， 另一个表示氢原子或氨基的保护基; R3表示氢原子或氨基的保护基）。

公开(公告)号：US08552072B2

公开(公告)日：2013-10-08

申请号：US12928584

申请日：2010-12-15

申请人： Asghar Peera ,  Ian Tomilnson ,  Glen Robinson

发明人： Asghar Peera ,  Ian Tomilnson ,  Glen Robinson

IPC分类号： C09K3/00 ,  C09C1/42 ,  C04B14/10 ,  C04B24/02 ,  C04B28/12 ,  C04B33/13 ,  C07C215/14 ,  C07C215/16 ,  C07C213/00 ,  C07C209/32 ,  C07C209/36

CPC分类号： C09C1/42 ,  C01P2006/22

摘要： A new class of compounds, namely diamino alcohols, is described, along with a process for their production and their use as rheology modifiers in high solids mineral slurries, such as, kaolin clay slurries.

摘要翻译： 描述了一类新的化合物，即二氨基醇，以及其生产方法及其作为高固体矿物浆料如高岭土粘土浆料中流变改性剂的用途。