公开(公告)号：US11020427B2

公开(公告)日：2021-06-01

申请号：US16851862

申请日：2020-04-17

Applicant: JFE MINERAL COMPANY, LTD.

Inventor： Etsurou Udagawa ,  Yuko Echizenya ,  Chisaki Miura ,  Yoshimi Nakata ,  Osamu Yamamoto

IPC: A61K33/30 ,  A61K8/27 ,  A61Q19/00 ,  A61L15/22 ,  A61P17/02

Abstract: Provided is a low-cost, easy-to-handle, effective therapeutic agent for wounds that is a therapeutic agent for skin wounds or rough skin that includes at least one selected from the group consisting of zinc chloride, zinc hydroxide, and zinc oxide and may include a pharmaceutically acceptable carrier.

公开(公告)号：US10987380B2

公开(公告)日：2021-04-27

申请号：US16468227

申请日：2017-12-08

Applicant: JFE MINERAL COMPANY, LTD.

Inventor： Yuko Echizenya ,  Yoshimi Nakata ,  Etsurou Udagawa ,  Osamu Yamamoto

IPC: A61K33/30 ,  A61L15/18 ,  A61L15/44 ,  A61P17/02 ,  C01G9/00

Abstract: An inorganic composition that is useful as an active ingredient for pharmaceuticals and has excellent stability comprises hydrozincite-containing zinc carbonate hydroxide hydrate produced by drying a precipitate. The precipitate is obtained by adding aqueous zinc nitrate solution, aqueous zinc sulfate solution or aqueous zinc chloride solution and aqueous sodium hydroxide solution dropwise to aqueous sodium hydrogen carbonate solution, a pH of the aqueous sodium hydrogen carbonate solution being maintained within a range of 6.5 to 9 by means of a pH controller. The hydrozincite-containing zinc carbonate hydroxide hydrate has an amount of dissolved Zn2+ ions of not less than 0.1 μg/m2 but not more than 7.33 μg/m2 and pH of not less than 7.2 and less than 8.3 after a dissolution test using stirring method.

公开(公告)号：US10780114B2

公开(公告)日：2020-09-22

申请号：US15735634

申请日：2016-06-10

Applicant: JFE MINERAL COMPANY, LTD.

Inventor： Etsurou Udagawa ,  Yuko Echizenya ,  Chisaki Miura ,  Yoshimi Nakata ,  Osamu Yamamoto

IPC: A61K33/30 ,  A61K8/27 ,  A61Q19/00 ,  A61L15/22 ,  A61P17/02

Abstract: Provided is a low-cost, easy-to-handle, effective therapeutic agent for wounds that is a therapeutic agent for skin wounds or rough skin that includes at least one selected from the group consisting of zinc chloride, zinc hydroxide, and zinc oxide and may include a pharmaceutically acceptable carrier.

公开(公告)号：US20220280686A1

公开(公告)日：2022-09-08

申请号：US17628313

申请日：2020-07-10

Applicant: JFE MINERAL COMPANY, LTD.

Inventor： Yoshimi Nakata ,  Etsurou Udagawa ,  Osamu Yamamoto

IPC: A61L27/04 ,  A61L27/16

Abstract: Provided is a bone regenerative agent which can repair a bone defect site with preventing from remaining at the bone defect site. The bone regenerative agent comprises zinc subcarbonate containing hydrozincite. It is preferred that the zinc subcarbonate has a Zn2+ ion elution amount of 0.1 ppm by mass or more after an elution test and also has a pH value of 7.2 or more and less than 8.3 after an elution test. It is preferred that some carbonate ions in the hydrozincite are substituted by sulfate ions or chloride ions. It is preferred that the bone regenerative agent is applied to a bone defect site.