公开(公告)号：US20250154526A1

公开(公告)日：2025-05-15

申请号：US18684984

申请日：2022-08-18

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Anna Nikolaevna STRELKOVA ,  Sergei Aleksandrovich LEGOTSKII ,  Tatiana Evgenievna SHUGAEVA ,  Pavel Mikhailovich GERSHOVICH ,  Alexandr Anatolevich NADOLINSKII ,  Pavel Andreevich IAKOVLEV ,  Dmitry Valentinovich MOROZOV

IPC: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  G16B20/50 ,  G16B30/10

Abstract: The present application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to a method for producing a modified adeno-associated virus (AAV) capsid and to a modified AAV capsid produced by said method, as well as to an isolated nucleic acid encoding said modified capsid and a vector based on recombinant adeno-associated virus for delivering a heterologous nucleic acid sequence to a subject, which includes said modified capsid.