公开(公告)号：US20230011234A1

公开(公告)日：2023-01-12

申请号：US17761838

申请日：2020-09-20

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrei Borisovich ULITIN ,  Aleksey Vladimirovich KONONOV ,  Sergei Andreevich AGEEV ,  Aleksandr Andreevich GORDEEV ,  Elena Vladimirovna VINOGRADOVA ,  Stanislav Rudolfovich EVDOKIMOV ,  Aleksandra Pavlovna SHMAKOVA ,  Ivan Vladimirovich MITROSHIN ,  Dmitry Valentinovich MOROZOV

IPC: C07K14/54 ,  C07K14/715 ,  A61P35/00

Abstract: The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokine comprising a heterodimeric protein complex based on an IL-15/IL-15Rα and an immunomodulatory antibody, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease.