公开(公告)号：US20230011234A1

公开(公告)日：2023-01-12

申请号：US17761838

申请日：2020-09-20

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrei Borisovich ULITIN ,  Aleksey Vladimirovich KONONOV ,  Sergei Andreevich AGEEV ,  Aleksandr Andreevich GORDEEV ,  Elena Vladimirovna VINOGRADOVA ,  Stanislav Rudolfovich EVDOKIMOV ,  Aleksandra Pavlovna SHMAKOVA ,  Ivan Vladimirovich MITROSHIN ,  Dmitry Valentinovich MOROZOV

IPC: C07K14/54 ,  C07K14/715 ,  A61P35/00

Abstract: The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokine comprising a heterodimeric protein complex based on an IL-15/IL-15Rα and an immunomodulatory antibody, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease.

公开(公告)号：US20220213209A1

公开(公告)日：2022-07-07

申请号：US17605933

申请日：2020-04-23

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrei Borisovich ULITIN ,  Olesya Nikolaevna KOZLOVA ,  Aleksandr Andreevich GORDEEV ,  Ksenia Mihailovna BURNYSHEVA ,  Anastasia Nikolaevna ISHUTINOVA ,  Aleksandra Aleksandrovna SOZONOVA ,  Sergei Andreevich AGEEV ,  Aleksandr Nikolaevich DORONIN ,  Vladimir Sergeevich TSYMPILOV ,  Ivan Vladimirovich MITROSHIN ,  Valery Vladimirovich SOLOVYEV ,  Iakov Iurevich USTIUGOV ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  C07K16/46 ,  A61P35/00

Abstract: The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.