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公开(公告)号：US5908452A
公开(公告)日：1999-06-01
申请号：US27358
申请日：1998-02-20
申请人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
发明人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
CPC分类号： A61F2/2403 , A61F2/0077 , A61F2310/00161 , A61F2310/00173 , A61F2310/00574 , Y10S623/90
摘要： A prosthetic heart valve is shown which incorporates a valve body design and leaflet pivot arrangements that minimize turbulence and shear stresses having a tendency to generate thrombosis. A valve body having an axially curved entrance that is smoothly joined to a generally cylindrical body of extended axial length provides excellent fluid flow characteristics when combined with leaflets that can assume orientations perfectly aligned with the downstream flow of blood. By constructing such a pyrocarbon valve body which receives a metal ring at an appropriate location, suture rings that permit the tissue annulus to directly contact the exterior surface of the cylindrical valve body are accommodated.
摘要翻译： 示出了一种假体心脏瓣膜，其包括阀体设计和小叶枢轴布置，其使具有产生血栓形成倾向的湍流和剪切应力最小化。 具有平滑地连接到延伸轴向长度的大致圆柱形主体的轴向弯曲入口的阀体当与能够呈现与下游血液流完全对准的方向的叶片组合时提供优异的流体流动特性。 通过构造这样一个在合适的位置接收金属环的热解碳体阀体，容纳了允许组织环直接接触圆柱形阀体的外表面的缝合环。
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公开(公告)号：US5545216A
公开(公告)日：1996-08-13
申请号：US441791
申请日：1995-05-16
申请人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
发明人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
CPC分类号： A61F2/2403 , A61F2/0077 , A61F2310/00161 , A61F2310/00173 , A61F2310/00574
摘要： A bileaflet heart valve is shown which incorporates a pivot arrangement that minimizes resistance to downstream blood flow in the open position yet has prompt response and therefore minimal regurgitation upon flow reversal. The valve employs a pair of identical flat leaflets that can assume a precisely parallel orientation in the fully open position at or near peak downstream blood flow or can alternatively assume other low energy positions. As the downstream flow of blood slows near the end of a pumping stroke, downstream displacement of the leaflets results in their prerotation toward the closed position orientation, all being controlled by the interengagement of flat ears, which extend laterally from opposite surfaces of the leaflets, and receiving cavities of unique design. The cavities include upstream and downstream lobes separated by an intermediate throat portion defined by inward and outward fulcrums. As soon as reverse flow begins, upstream displacement of the leaflets causes the ears to contact straight camming surfaces located upstream of the outward fulcrums which, in combination with the fulcrums and a downwardly directed, concave surface at the upstream end of the upstream lobe, positively guide each leaflet through efficient closing which ends in substantially rotational movement.
摘要翻译： 显示了一种双轨心脏瓣膜，其包括枢转装置，其使得在打开位置中对下游血流的抵抗力最小化，但是具有迅速的反应并且因此在流动反转时具有最小的反流。 该阀采用一对相同的平面小叶，其可在靠近血液下游血流处或其附近的完全打开位置呈现精确平行的取向，或者可以采取其它低能量位置。 随着下游血液流动在泵送冲程结束时减慢，小叶的下游位移导致其朝向关闭位置取向的预旋转，全部由通过相对于传单的相对表面横向延伸的平耳的相互接合来控制， 并接收独特设计的腔体。 空腔包括由内向和向外的支点限定的中间喉部分隔开的上游叶和下游叶。 一旦反向流动开始，小叶的上游位移将使耳朵接触位于外侧支点上游的直接凸轮表面，该支撑点与上游叶的上游端的支点和向下指向的凹面结合，呈正向 通过高效关闭来引导每个小叶，其基本上旋转运动结束。
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公开(公告)号：US08303652B2
公开(公告)日：2012-11-06
申请号：US11568259
申请日：2006-01-23
IPC分类号： A61F2/24
CPC分类号： A61F2/2427
摘要： A heart valve holder-inserter (21, 121) is designed to facilitate easy implantation of a mechanical heart valve prosthesis (23, 123). This holder-inserter, at its distal end, incorporates a pair of diametrically opposed guide members (47, 49, 81, 147, 149) which extend well beyond the leading edge of the prosthesis and which have exterior surfaces (53, 83, 153) of substantial dimension that are smoothly curved and proportioned so as to slowly spread the tissue annulus in order to facilitate easy entrance thereinto of the leading edge portion of the mechanical valve body.
摘要翻译： 心脏瓣膜保持器插入器（21,121）被设计成便于容易植入机械心脏瓣膜假体（23,123）。 该保持器插入件在其远端处包括一对直径相对的引导构件（47,49,81,147,149），该引导构件延伸得远远超出假体的前缘，并且具有外表面（53,83,153 ），其平滑地弯曲和成比例地缓慢地扩展组织环，以便于容易地进入机械阀体的前缘部分。
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公开(公告)号：US5641324A
公开(公告)日：1997-06-24
申请号：US589864
申请日：1996-01-23
申请人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
发明人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
CPC分类号： A61F2/2403 , A61F2/0077 , A61F2310/00161 , A61F2310/00173 , A61F2310/00574
摘要： A bileaflet heart valve incorporates a pivot arrangement that minimizes resistance to downstream blood flow in the open position yet has prompt response and therefore minimal regurgitation upon flow reversal. A valve body having an axially curved entrance that smoothly joins a generally cylindrical body of extended axial length provides excellent fluid flow characteristics when combined with leaflets that can assume orientations perfectly aligned with the downstream flow of blood. Identical flat leaflets can assume a parallel orientation in the fully open position during downstream blood flow or can assume other low energy positions. Flat ears, which extend laterally from opposite surfaces of the leaflets, interengage with cavities of unique design having upstream and downstream lobes separated by an intermediate throat portion defined by inward and outward fulcrums. The downstream lobes may be designed to facilitate movement to the parallel orientation or to cause the leaflets to optionally prerotate toward the closed position. As soon as reverse flow begins, upstream displacement of the leaflets causes the ears to contact straight camming surfaces located upstream of the outward fulcrums which, in combination with the fulcrums and a downwardly directed, concave surface at the upstream end of the upstream lobe, positively guide each leaflet through efficient closing which ends in substantially rotational movement. A pyrocarbon valve body receives suture rings that permit the tissue annulus to directly contact an exterior surface region of the valve body.
摘要翻译： 双流心脏瓣膜包括枢轴装置，其使得在打开位置中对下游血流的抵抗力最小化，但具有迅速的反应，因此在流动反转时具有最小的反流。 具有平滑地连接延伸轴向长度的大致圆柱形主体的轴向弯曲入口的阀体当与能够呈现与下游血液流完全对准的方向的叶片组合时提供优异的流体流动特性。 相同的扁平小叶可以在下游血流期间在完全打开位置呈现平行取向，或者可以采取其他低能量位置。 平面耳朵从小叶的相对表面横向延伸，与独特设计的空腔相互联系，具有由内向和向外支点限定的中间喉部分隔的上游和下游叶片。 下游叶片可以被设计成便于移动到平行取向或使得小叶可选择性地朝向关闭位置旋转。 一旦反向流动开始，小叶的上游位移将使耳朵接触位于外侧支点上游的直接凸轮表面，该支撑点与上游叶的上游端的支点和向下指向的凹面结合，呈正向 通过高效关闭来引导每个小叶，其基本上旋转运动结束。 热碳体阀体接收缝合环，其允许组织环直接接触阀体的外表面区域。
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公开(公告)号：US5772694A
公开(公告)日：1998-06-30
申请号：US441809
申请日：1995-05-16
申请人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
发明人： Jack C. Bokros , John L. Ely , Michael R. Emken , Axel D. Haubold , T. Scott Peters , Jonathan C. Stupka , C. Thomas Waits
CPC分类号： A61F2/2403 , A61F2/0077 , A61F2310/00161 , A61F2310/00173 , A61F2310/00574 , Y10S623/90
摘要： A prosthetic heart valve is shown which incorporates a valve body design and leaflet pivot arrangements that minimize turbulence and shear stresses having a tendency to generate thrombosis. A valve body having an axially curved entrance that is smoothly joined to a generally cylindrical body of extended axial length provides excellent fluid flow characteristics when combined with leaflets that can assume orientations perfectly aligned with the downstream flow of blood. By constructing such a pyrocarbon valve body which receives a metal ring at an appropriate location, suture rings that permit the tissue annulus to directly contact the exterior surface of the cylindrical valve body are accommodated.
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公开(公告)号：US6059826A
公开(公告)日：2000-05-09
申请号：US64614
申请日：1998-04-22
IPC分类号： A61F2/24
CPC分类号： A61F2/2403
摘要： A trileaflet heart valve includes a generally annular valve body having an interior wall of nominally circular cross-section into which three wedge-shaped projections radially extend to provide three pairs of flanking flat surfaces between which three leaflets are pivotally supported. The valve body has an outwardly flaring upstream entrance end that, together with the configuration of the leaflets, assures streamlined flow and low transvalvular pressure drop. Wing sections extend laterally in both directions at angles between about 30.degree. and 50.degree. from flat central sections of the leaflets to create V-shaped cross-section leaflet bodies having short flat edge sections along the lateral edges of both wing sections that create a wide open central flow passageway. The three leaflets assume an orientation parallel or nearly parallel to the central axis in full open position. Leaflet movement from open to closed position is partially defined by upstream retainers aligned with the flat central sections of each leaflet and by surfaces formed in or on the side walls of the projections along which the leaflets slide. Radially interior edges of the leaflets are tapered to effectively eliminate cavitation.
摘要翻译： 三叶形心脏瓣膜包括大体上环形的阀体，其具有标称圆形横截面的内壁，三个楔形突起沿径向延伸以提供三对侧面平坦表面，三个叶片枢转地支撑在该平面之间。 阀体具有向外扩张的上游入口端，其与传单的构造一起确保流线型流动和低跨压力压降。 翼形部分从平板中央部分的角度在两个方向上在两个方向上横向延伸，以形成沿着两个翼部分的侧边缘具有短平坦边缘部分的V形横截面小叶体，其形成宽 打开中央流通道。 三个小叶假定在完全打开位置平行或几乎平行于中心轴的方向。 从打开到关闭位置的小叶运动部分地由与每个叶片的平坦中心部分对准的上游保持器以及形成在小叶滑动的突起的侧壁中或其上的表面部分地限定。 叶片的径向内缘是锥形的，以有效消除气蚀。
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公开(公告)号：US5246453A
公开(公告)日：1993-09-21
申请号：US919285
申请日：1992-07-24
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2403 , Y10T137/7898
摘要： Bi-leaflet and single occluder heart valves have improved pivot arrangements that create quick valve response to flow reversal and minimize impact. Valve members or occluders, which have curved inflow and outflow surfaces, are slidably and pivotally mounted in a heart valve body and can be aligned precisely parallel to blood flow in the open position. Lugs on the valve members engage surfaces on projections extending radially inward from flat wall sections in the valve body sidewall, and the shape and relationship of these interengaging surfaces provide prompt initial rotation, low wear and reduced impact upon closing. Laterally directed ears engage the valve body arcuate sidewall and assist in defining the path of closing movement.
摘要翻译： 双瓣和单闭塞心脏瓣膜具有改进的枢轴布置，可以对流量反转产生快速的阀响应并最小化冲击。 具有弯曲的流入和流出表面的阀构件或闭塞器可滑动地且可枢转地安装在心脏瓣膜体中，并且能够在打开位置上精确地平行于血液流动地对齐。 阀构件上的凸块接合从阀体侧壁中的平壁部分径向向内延伸的突起上的表面，并且这些相互接合的表面的形状和关系提供快速的初始旋转，低磨损和减小的关闭冲击。 侧向引导的耳朵接合阀体弓形侧壁，并协助限定关闭运动的路径。
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公开(公告)号：US5236449A
公开(公告)日：1993-08-17
申请号：US888872
申请日：1992-05-26
IPC分类号： A61F2/24
CPC分类号： A61F2/2403
摘要： Prosthetic heart valves having a single occluder, or a pair of identical mating occluders, guided in their movement from the open to the closed position by pairs of elongated slots in diametrically opposed flat sidewall sections of the valve body. Each occluder is formed with two ears that protrude from opposite flat side surfaces along the lateral edges thereof. The ears may be frustoconical or hemispherical or the like and are slidingly received in elongated slots which can be straight or arcuate. The main body portions of the occluders have rectilinear surfaces that are aligned parallel to the centerline through the valve in the open position, so as to give low resistance to blood flow. However, when the backflow of blood displaces the occluders upstream, the slot arrangements are such that even though the occluder bodies are parallel, pivoting towards the closed position orientation begins essentially immediately, and the closing movement is of short duration so as to minimize regurgitation.
摘要翻译： 具有单个封堵器或一对相同的配合封堵器的假体心脏瓣膜通过在阀体的直径相对的平坦侧壁部分中的成对的细长狭槽从开口向闭合位置引导。 每个封堵器形成有两个耳朵，沿着其横向边缘从相对的平坦侧表面突出。 耳朵可以是截头圆锥形或半球形等，并且可滑动地容纳在可以是直的或弓形的细长槽中。 闭塞器的主体部分具有直线表面，其在打开位置通过阀平行于中心线排列，以便给予低血流阻力。 然而，当血液回流使封堵器上游位移时，狭槽结构使得即使闭塞器体是平行的，朝向关闭位置方向的枢转基本上立即开始，并且闭合运动具有短持续时间，从而使反流最小化。
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公开(公告)号：US5192309A
公开(公告)日：1993-03-09
申请号：US837761
申请日：1992-02-18
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2403 , Y10T137/7875 , Y10T137/7898
摘要： Heart valves, particularly those having two identical leaflets, are shown which utilize improved pivot arrangements that create prompt response to flow reversal and minimize impact at the instant of closing. Illustrated are valves having pairs of leaflets that can assume an orientation in the fully open position that is precisely parallel to the centerline of the passageway, yet which will promptly respond upon blood flow reversal and quickly close to prevent substantial regurgitation. The ability of the leaflets to assume a precisely parallel or low energy position in the bloodstream reduces pressure drop across the valve and results in improved flow characteristics. Prompt closing movement pivoting from a parallel position is effected by creating a camming action adjacent the upstream edges of the leaflets while positively guiding the overall path of leaflet translation and rotation by interengagement at other locations spaced from the upstream edges. The pivot arrangements are particularly effective to positively guide the leaflets to assure effective closing movement regardless of momentary deviations in the dynamics of the reverse flow of blood through the valve.
摘要翻译： 心脏瓣膜，特别是具有两个相同小叶的心脏瓣膜被示出，其利用改进的枢转结构，其产生对流动反转的快速响应并且在关闭时将冲击最小化。 示出了具有成对的传单的瓣膜，其可以在完全打开位置呈现精确平行于通道的中心线的方向，但是其将迅速响应于血流反转并快速关闭以防止大量反流。 小叶在血流中呈现精确平行或低能量位置的能力降低了阀门上的压降，从而改善了流动特性。 通过在传播叶片的上游边缘附近产生凸轮作用，同时通过在与上游边缘间隔开的其它位置处的相互接合而正确地引导小叶平移和旋转的整个路径来实现从平行位置枢转的快速关闭运动。 枢轴布置特别有效地积极地引导传单以确保有效的闭合运动，而不管通过阀的反向血流的动力学的瞬时偏差。
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公开(公告)号：US5843183A
公开(公告)日：1998-12-01
申请号：US854958
申请日：1997-05-13
申请人： Jack C. Bokros , Jonathan C. Stupka
发明人： Jack C. Bokros , Jonathan C. Stupka
IPC分类号： A61F2/24
CPC分类号： A61F2/2403
摘要： A trileaflet heart valve includes a generally annular valve body having an interior wall of nominally circular cross-section into which three wedge-shaped projections radially extend to provide three pairs of flanking flat surfaces between which three leaflets are pivotally supported. The valve body has an outwardly flaring upstream entrance end that, together with the configuration of the leaflets, assures streamlined flow and low transvalvular pressure drop. Wing sections extend laterally in both directions at angles between about 30.degree. and 50.degree. from flat central sections of the leaflets to create V-shaped cross-section leaflet bodies having short flat edge sections along the lateral edges of both wing sections that create a wide open central flow passageway. The three leaflets assume an orientation parallel or nearly parallel to the central axis in full open position. Leaflet movement from open to closed position is partially defined by upstream retainers aligned with the flat central sections of each leaflet and by surfaces formed in or on the side walls of the projections along which the leaflets slide.
摘要翻译： 三叶形心脏瓣膜包括大体上环形的阀体，其具有标称圆形横截面的内壁，三个楔形突起沿径向延伸以提供三对侧面平坦表面，三个叶片枢转地支撑在该平面之间。 阀体具有向外扩张的上游入口端，其与传单的构造一起确保流线型流动和低跨压力压降。 翼形部分从平板中央部分的角度在两个方向上在两个方向上横向延伸，以形成沿着两个翼部分的侧边缘具有短平坦边缘部分的V形横截面小叶体，其形成宽 打开中央流通道。 三个小叶假定在完全打开位置平行或几乎平行于中心轴的方向。 从打开到关闭位置的小叶运动部分地由与每个叶片的平坦中心部分对准的上游保持器以及形成在小叶滑动的突起的侧壁中或其上的表面部分地限定。
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