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    Methods for Treating and Preventing Apoptosis-Related Diseases Using Rna Interfering Agents
    3.
    发明申请
    Methods for Treating and Preventing Apoptosis-Related Diseases Using Rna Interfering Agents 审中-公开
    使用Rna干扰剂治疗和预防凋亡相关疾病的方法

    公开(公告)号：US20070254850A1

    公开(公告)日：2007-11-01

    申请号：US10533622

    申请日：2003-10-30

    申请人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Nedim Ince ,  Premlata Shankar

    发明人： Judy Lieberman ,  Manjunath Narasimhaswamy ,  Erwei Song ,  Sang-Kyung Lee ,  Nedim Ince ,  Premlata Shankar

    IPC分类号： A61K48/00 ,  C12N15/867 ,  C12N5/08

    CPC分类号： C12N15/1136 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2799/027

    摘要： The present invention is based, at least in part, on the discovery of compositions and methods useful in the modulation, e.g., inhibition, of gene expression or protein activity. In particular, the present invention is based on novel RNA interfering agents, e.g., siRNA molecules which target apoptosis-related genes or proinflammatory cytokines, and result in reduction, e.g., prolonged reduction, of apoptosis-related gene expression or proinflammatory cytokine expression in cells. Inhibition of apoptosis-related gene expression or protein activity or proinflammatory cytokine expression or protein activity, e.g., by the siRNAs of the invention, inhibits apoptosis-mediated diseases or disorders and proinflammatory cytokine mediated diseases or disorders, including, for example, transplant rejection, hepatitis, liver injury, sepsis, and cancer.

    摘要翻译： 本发明至少部分地基于发现可用于调节，例如抑制基因表达或蛋白质活性的组合物和方法。 特别地，本发明基于新的RNA干扰剂，例如靶向凋亡相关基因或促炎细胞因子的siRNA分子，并导致细胞凋亡相关基因表达或促炎细胞因子表达的减少，例如延长的减少 。 抑制凋亡相关基因表达或蛋白质活性或促炎细胞因子表达或蛋白质活性，例如通过本发明的siRNA抑制细胞凋亡介导的疾病或病症和促炎细胞因子介导的疾病或病症，包括例如移植排斥反应， 肝炎，肝损伤，败血症和癌症。