公开(公告)号：US20070255402A1

公开(公告)日：2007-11-01

申请号：US11743094

申请日：2007-05-01

申请人： Jacob J. Moore ,  David H. Pashley ,  Balamurali K. Ambati

发明人： Jacob J. Moore ,  David H. Pashley ,  Balamurali K. Ambati

IPC分类号： A61F2/14

CPC分类号： A61L26/0061 ,  A61L26/0014 ,  C08L33/08

摘要： A method for convenient, controlled wound closure of an eye, the skin, internal organs and other soft tissue which comprises administering to the wound a sterile, body compatible photopolymerizable acrylate or methacrylate adhesive, and exposing the applied adhesive to light.

摘要翻译： 一种对眼睛，皮肤，内部器官和其他软组织进行方便，受控的伤口闭合的方法，其包括向伤口施用无菌的身体相容的可光聚合的丙烯酸酯或甲基丙烯酸酯粘合剂，并将所施加的粘合剂暴露于光。

公开(公告)号：US06506055B1

公开(公告)日：2003-01-14

申请号：US09417868

申请日：1999-10-13

申请人： David H. Pashley ,  Ricardo M. Carvalho ,  Jose C. Pereira

发明人： David H. Pashley ,  Ricardo M. Carvalho ,  Jose C. Pereira

IPC分类号： A61K608

CPC分类号： A61K6/08 ,  A61K6/0023 ,  A61K6/0029 ,  A61K6/06

摘要： A method of reducing dentin sensitivity comprising: applying an effective amount of an acid to a dentin surface to form a treated surface; and administering an effective amount of an acidic oxalate to the treated surface so as to occlude dentinal tubules beneath the dentin surface. The method may optionally comprise the subsequent application of a suitable bonding agent. The invention further provides a kit for the treatment of dentin sensitivity, comprising a first container of an acid treatment composition, and a second container of an acidic oxalate composition.

公开(公告)号：US06406529B1

公开(公告)日：2002-06-18

申请号：US09059714

申请日：1998-04-13

申请人： David H. Pashley ,  Ricardo M. Carvalho ,  Jose C. Pereira

发明人： David H. Pashley ,  Ricardo M. Carvalho ,  Jose C. Pereira

IPC分类号： A61K602

CPC分类号： A61K8/24 ,  A61K6/0017 ,  A61K6/0029 ,  A61K8/362 ,  A61K2800/88 ,  A61Q11/00

摘要： A method of reducing dentin sensitivity comprising: applying an effective amount of an acid to a dentin surface to form a treated surface; and administering an effective amount of an acidic oxalate to the treated surface so as to occlude dentinal tubules beneath the dentin surface. The method may optionally comprise the subsequent application of a suitable bonding agent. The invention further provides a kit for the treatment of dentin sensitivity, comprising a first container of an acid treatment composition, and a second container of an acidic oxalate composition.

摘要翻译： 一种降低牙质敏感性的方法，包括：将有效量的酸施用于牙本质表面以形成经处理的表面; 并向经处理的表面施用有效量的酸性草酸盐，以封闭牙本质表面下方的牙质小管。 该方法可以任选地包括随后施加合适的粘合剂。 本发明还提供了用于治疗牙本质敏感性的试剂盒，其包含酸处理组合物的第一容器和酸性草酸盐组合物的第二容器。

公开(公告)号：US4538990A

公开(公告)日：1985-09-03

申请号：US653321

申请日：1984-09-24

申请人： David H. Pashley

发明人： David H. Pashley

IPC分类号： A61K6/00 ,  A61K8/362 ,  A61Q11/00 ,  A61K6/08

CPC分类号： A61Q11/00 ,  A61K6/0017 ,  A61K6/0029 ,  A61K8/362

摘要： A method of decreasing the permeability of dental cavity preparations comprising the steps of first applying from 1 to 30% w/v neutral oxalate salt solution, such as dipotassium oxalate to the smear layer and then applying 0.5 to 3% w/v of an acidic oxalate salt solution, such as a monopotassium monohydrogen oxalate, to the layer. The resultant layer of microscopic calcium oxalate crystals makes the dentin surface more resistant to acid attack.

摘要翻译： 一种降低牙腔制剂渗透性的方法，包括以下步骤：首先将1至30％w / v中草酸盐溶液（如草酸二钾）施用于涂片层，然后施加0.5至3％w / v的酸性 草酸盐溶液，如草酸一钾一水合物。 所得到的微观草酸钙晶体层使得牙本质表面更耐酸侵蚀。

公开(公告)号：US4057621A

公开(公告)日：1977-11-08

申请号：US689110

申请日：1976-05-24

申请人： David H. Pashley ,  William C. Outhwaite

发明人： David H. Pashley ,  William C. Outhwaite

IPC分类号： A61K8/362 ,  A61Q11/00 ,  A61K7/16

CPC分类号： A61Q11/00 ,  A61K8/362

摘要： A composition and method of treatment for desensitizing hypersensitive dentin and cementum capable of effective results specially in one-treatment application. The essential ingredient or compound of the desensitizing composition is an alkali metal or ammonium oxalate where this salt may be mono- or di-substituted. The hydrogen or mono-substituted salts are preferred due to their lower pH which renders them more efficient in the protocol of this invention. These oxalates may be used effectively in the range 0.5% by weight to aqueous solution saturation. However, a range of 2.0% to solution saturation is much preferred due to the practice of the invention as a single-treatment agent. Furthermore, saturated solutions of the oxalates are most preferred also due to greater efficiency. The compositions may be used in aqueous solutions and as non-toxic paste with conventional fillers and excipients. In the paste form, the oxalate is preferred in a weight percent basis of 2-18%.

摘要翻译： 一种用于脱敏敏感性牙本质和牙骨质的组合物和方法，其能够在一次治疗中有效。 脱敏组合物的基本成分或化合物是碱金属或草酸铵，其盐可以是单取代或二取代的。 氢或单取代的盐是优选的，因为它们的较低的pH使得它们在本发明的方案中更有效。 这些草酸盐可以在0.5重量％范围内有效地用于水溶液饱和。 然而，由于将本发明作为单一处理剂的实践，所以对溶液饱和度的2.0％的范围是优选的。 此外，由于更高的效率，草酸盐的饱和溶液是最优选的。 该组合物可以用于水溶液和作为无毒糊剂与常规填料和赋形剂。 在糊状形式中，草酸盐的重量百分比优选为2-18％。