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公开(公告)号：US20070255402A1
公开(公告)日：2007-11-01
申请号：US11743094
申请日：2007-05-01
IPC分类号： A61F2/14
CPC分类号： A61L26/0061 , A61L26/0014 , C08L33/08
摘要： A method for convenient, controlled wound closure of an eye, the skin, internal organs and other soft tissue which comprises administering to the wound a sterile, body compatible photopolymerizable acrylate or methacrylate adhesive, and exposing the applied adhesive to light.
摘要翻译： 一种对眼睛，皮肤，内部器官和其他软组织进行方便，受控的伤口闭合的方法，其包括向伤口施用无菌的身体相容的可光聚合的丙烯酸酯或甲基丙烯酸酯粘合剂，并将所施加的粘合剂暴露于光。
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公开(公告)号：US10064819B2
公开(公告)日：2018-09-04
申请号：US13543597
申请日：2012-07-06
IPC分类号： A61M31/00 , A61K9/00 , A61K31/573 , A61K9/20
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the delivery device is adapted to fit within a lens capsule or ciliary sulcus of an eye. The delivery device can be inserted into the lens capsule or ciliary sulcus of an eye during cataract surgery or for treatment of uveitis.
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公开(公告)号：US20160030502A1
公开(公告)日：2016-02-04
申请号：US14817973
申请日：2015-08-04
IPC分类号： A61K38/06 , A23L1/30 , A61K36/185 , A61K36/45 , A61K36/48 , A61K31/12 , A61K31/122 , A23L1/29 , A61K36/88
CPC分类号： A61K38/063 , A23L33/105 , A23L33/40 , A23V2002/00 , A61K31/12 , A61K31/122 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/8962 , A61K36/9066 , A23V2200/30 , A23V2250/21 , A23V2250/2106 , A23V2250/2112 , A23V2250/212 , A23V2250/31 , A61K2300/00
摘要： An eye health supplement administered to a person in order to prevent and treat eye-related conditions or diseases. The eye health supplement focuses on treating conditions and diseases, such as diabetic retinopathy, macular degeneration, hypertensive retinopathy, keratoconjunctivitis sicca, and more, and the underlying symptoms of eye-related conditions and diseases through the inclusion of a quantity of birch leaf powder, a quantity of pomegranate, a quantity of garlic bulb powder, a quantity of fenugreek powder, a quantity of curcumin, a quantity of asthaxanthin, a quantity of bilberry extract powder, and a quantity of glutathione powder. The quantity of birch leaf powder, the quantity of pomegranate, the quantity of garlic bulb powder, the quantity of fenugreek powder, the quantity of curcumin, the quantity of asthaxanthin, the quantity of bilberry extract powder, and the quantity of glutathione powder are heterogeneously mixed into a supplement mixture for oral or transdermal administration.
摘要翻译： 为了预防和治疗与眼睛有关的病症或疾病，向人施用的眼睛健康补充剂。 眼健康补品专注于治疗糖尿病性视网膜病变，黄斑变性，高血压性视网膜病变，透角结膜炎等病症和疾病，以及通过包含一定数量的白桦叶粉末引起的眼睛相关病症和疾病的潜在症状， 一定数量的石榴，一定数量的大蒜球粉，一定数量的葫芦巴粉，一定数量的姜黄素，一定数量的青ax素，一定量的越橘提取物粉末和一定量的谷胱甘肽粉。 白桦叶粉的数量，石榴的数量，大蒜球粉的数量，葫芦巴粉的数量，姜黄素的量，天竺葵的量，越桔提取物粉末的量和谷胱甘肽粉的数量是不均匀的 混合成用于口服或透皮给药的补充混合物。
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公开(公告)号：US09095404B2
公开(公告)日：2015-08-04
申请号：US13211169
申请日：2011-08-16
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device (40) having an active agent reservoir (44) disposed in an annular body (42), the annular body (42) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule.
摘要翻译： 用于将活性剂递送到受试者眼睛的装置，系统和方法可以包括具有设置在环形体（42）中的活性剂储存器（44）的眼部活性剂递送装置（40），所述环形体 42）被配置成装配在透镜胶囊内部并且至少部分地环绕眼镜片内的眼内透镜的视线。
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公开(公告)号：US20130302398A1
公开(公告)日：2013-11-14
申请号：US13543597
申请日：2012-07-06
IPC分类号： A61K9/00 , A61K31/573
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0017 , A61K9/2031 , A61K31/573
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the delivery device is adapted to fit within a lens capsule or ciliary sulcus of an eye. The delivery device can be inserted into the lens capsule or ciliary sulcus of an eye during cataract surgery or for treatment of uveitis.
摘要翻译： 用于将活性剂递送到受试者眼睛的装置，系统和方法可以包括包含分散在可生物降解的活性剂基质内的活性剂的眼内活性剂递送装置。 活性剂包括地塞米松，并且输送装置适于装配在眼睛的晶状体囊或睫状沟内。 在白内障手术期间，输送装置可以插入眼睛的晶状体囊或睫状沟，或用于治疗葡萄膜炎。
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公开(公告)号：US09534222B2
公开(公告)日：2017-01-03
申请号：US14358572
申请日：2012-11-15
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2310/3233 , C12N2320/33
摘要： Various methods and compositions relating to vascular endothelial growth factor receptor 2 (VEGFR2) are provided. In one aspect, a method of increasing expression of the soluble form of VEGFR2 (sVEGFR2) in a subject can include binding an antisense morphoiino to an exon13-intron13 splicing site of VEGFR2 mRNA such that the VEGFR2 niRNA is spliced into a sVEGFR2 isoform.
摘要翻译： 提供了与血管内皮生长因子受体2（VEGFR2）相关的各种方法和组合物。 一方面，增加受试者中可溶形式的VEGFR2（sVEGFR2）的表达的方法可包括将反义形态结合到VEGFR2 mRNA的外显子13-内含子13剪接位点，使得VEGFR2 niRNA被剪接成sVEGFR2同种型。
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公开(公告)号：US20150100046A1
公开(公告)日：2015-04-09
申请号：US14050226
申请日：2013-10-09
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61B3/16 , A61F2002/16901 , A61F2250/0068 , A61K9/0051
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. An ocular active agent delivery device can include an active agent reservoir disposed in an annular housing, the annular housing being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device can further allow diffusion of an active agent from the active agent reservoir.
摘要翻译： 本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。 眼部活性剂递送装置可以包括设置在环形壳体中的活性剂储存器，所述环形壳体被配置为装配在透镜囊内部并且至少部分地环绕透镜囊内的眼内透镜的视线。 该装置还可以允许活性剂从活性剂储存器扩散。
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公开(公告)号：US08663194B2
公开(公告)日：2014-03-04
申请号：US12945428
申请日：2010-11-12
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译： 本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。 在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部， 至少部分地包围晶状体囊内的眼内透镜的视线。 装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。 此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。
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公开(公告)号：US20120089113A1
公开(公告)日：2012-04-12
申请号：US13211169
申请日：2011-08-16
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Devices, systems, and methods for delivery of an active agent into the eye of a subject can include an ocular active agent delivery device (40) having an active agent reservoir (44) disposed in an annular body (42), the annular body (42) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule.
摘要翻译： 用于将活性剂递送到受试者眼睛的装置，系统和方法可以包括具有设置在环形体（42）中的活性剂储存器（44）的眼部活性剂递送装置（40），所述环形体 42）被配置为装配在透镜胶囊内部并且至少部分地环绕眼镜片内的眼内透镜的视线。
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公开(公告)号：US20110282328A1
公开(公告)日：2011-11-17
申请号：US12945428
申请日：2010-11-12
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , B33Y80/00
摘要： The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
摘要翻译： 本发明提供了将活性剂递送到受试者的眼睛中的装置，系统和方法。 在一个方面，例如，眼部活性剂递送装置（10）可以包括设置在环形壳体（12）中的活性剂储存器（14），所述环形壳体（12）被配置成装配在透镜囊内部， 至少部分地包围晶状体囊内的眼内透镜的视线。 装置（10）还可以包括可操作地耦合到活性剂储存器（14）的半透膜（16），其中半透膜（16）构造成允许活性剂从活性剂储存器（14）扩散。 此外，阀（18）可以可操作地联接到活性剂储存器（14），其中阀（18）构造成允许用活性剂填充活性剂储存器（14）。
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