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公开(公告)号：US20070118914A1
公开(公告)日：2007-05-24
申请号：US11544230
申请日：2006-10-06
申请人： Jacques Banchereau , Anna Palucka
发明人： Jacques Banchereau , Anna Palucka
IPC分类号： A01K67/027
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A01K2267/0381
摘要： The present invention includes a model system and use of the same for the study, manipulation and focusing of the human immune in a mammal, e.g., a nonhuman mammal that is immune deficient with one or more human hematopoietic progenitor cells and one or more human tumor cell lines.
摘要翻译： 本发明包括模型系统及其用于研究，操纵和聚焦哺乳动物（例如，与一种或多种人类造血祖细胞和一种或多种人肿瘤免疫缺陷的非人哺乳动物）的用途 细胞系。
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公开(公告)号：US20070202106A1
公开(公告)日：2007-08-30
申请号：US11687641
申请日：2007-03-17
申请人： Anna Palucka , Jacques Banchereau
发明人： Anna Palucka , Jacques Banchereau
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331
摘要： The present invention includes compositions and methods for the treatment, diagnosis and prognosis of cancers by detecting the level of IL-13 expression in cancerous cells in the tissue microenvironment as an indicator of controlling the type of immune response mounted against the cancer.
摘要翻译： 本发明包括通过检测组织微环境中癌细胞中IL-13表达的水平作为控制针对癌症的免疫应答类型的指标来治疗，诊断和预后的组合物和方法。
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公开(公告)号：US20060051358A1
公开(公告)日：2006-03-09
申请号：US11135733
申请日：2005-05-24
申请人： Jacques Banchereau , John Connolly , Anna Palucka , Hideki Ueno
发明人： Jacques Banchereau , John Connolly , Anna Palucka , Hideki Ueno
CPC分类号： C12N15/1034 , C40B30/04 , C40B40/10 , G01N33/5023 , G01N33/505 , G01N33/6863 , G01N33/6878 , G01N2800/24 , G01N2800/52
摘要： The present invention includes compositions and methods for identifying T-cell epitopes independent of the subject's HLS type by simultaneously analyzing the culture for multiple parameters of immune reactivity to identify at least one epitope wherein the epitopes that elicit immune reactivity of interest in the subset are identified as targeting agents for the subset.
摘要翻译： 本发明包括用于通过同时分析培养物的多个免疫反应参数来鉴定至少一个表位的T细胞表位的识别，所述组合物和方法独立于受试者的HLS型，鉴定其中鉴定出在该子集中引起感兴趣的免疫反应性的表位 作为子集的定位代理。
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4.发明申请Dendritic Cells Generated Using GM-CSF and Interferon Alpha and Loaded with Heat-Treated and Killed Cancer Cells 审中-公开使用GM-CSF和干扰素α产生的树突状细胞，并加载热处理和杀死的癌细胞公开(公告)号：US20080031900A1
公开(公告)日：2008-02-07
申请号：US11771664
申请日：2007-06-29
IPC分类号： A61P35/00
CPC分类号： A61K39/0011 , A61K2039/5154 , C12N5/0639 , C12N2501/22 , C12N2501/24 , C12N2501/25
摘要： The present invention includes compositions and methods for making a pharmaceutically effective amount of one or more dendritic cells matured by exposure to IFNα loaded with cancer antigens from cells that are heat shocked and subsequently killed, wherein the one or more IFNα dendritic cells are under conditions to present the one or more cancer antigens are presented within the context of autologous MHC.
摘要翻译： 本发明包括通过暴露于热休克并随后被杀死的细胞暴露于载有癌抗原的IFNα而成为药物有效量的一种或多种树突状细胞的组合物和方法，其中所述一种或多种IFNα树突状细胞处于 存在一种或多种癌抗原在自体MHC的上下文中呈现。
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公开(公告)号：US20070237763A1
公开(公告)日：2007-10-11
申请号：US11544229
申请日：2006-10-06
申请人： Jacques Banchereau , Anna Palucka
发明人： Jacques Banchereau , Anna Palucka
IPC分类号： A61K39/395 , A61K45/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K38/1793 , A61K38/2086 , A61K39/395 , A61K45/06
摘要： The present invention includes compositions and methods for the treatment of cancers by controlling the type of immune response mounted against the tumor, and more particularly, the treatment of tumors with cytokine antagonists to change the type of helper T cell response and inhibition of angiogenesis, prevention of formation of metastasis and prevention of formation of tumor stroma.
摘要翻译： 本发明包括通过控制针对肿瘤的免疫应答的类型来治疗癌症的组合物和方法，更具体地，用细胞因子拮抗剂治疗肿瘤以改变辅助性T细胞应答的类型和抑制血管生成，预防 形成转移和预防肿瘤基质的形成。
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