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公开(公告)号：US07799762B2
公开(公告)日：2010-09-21
申请号：US10169053
申请日：2000-12-21
IPC分类号： A61K38/00
CPC分类号： A61K38/04 , A61K39/385 , A61K47/6811 , A61K2039/6018 , A61K2039/6037 , C07C237/22 , C07C323/60 , C07F9/091 , C07K5/04 , Y02A50/412
摘要： The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state.Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targeting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.
摘要翻译： 本发明特别涉及衍生自功能取代的氨基酸的二肽样化合物，其具有通过所述二肽类化合物的胺官能团的酰胺化而结合的脂肪酸链，其一个末端部分具有辅助功能侧链 间隔物，另一端部分为中性或带电状态的酸基。 本发明的化合物具有如佐剂的免疫调节特性。此外，本发明的化合物可以接枝在给定抗原上以调节或调节免疫应答，或者可以同样地接枝在药物载体上以增强治疗效果或靶向 其中。 因此，本发明的化合物可用作人和兽医学作为免疫原和诊断工具。
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2.发明授权Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same 失效酰基假二肽，制备方法和含有它们的药物组合物公开(公告)号：US07157092B1
公开(公告)日：2007-01-02
申请号：US09720045
申请日：1999-06-23
IPC分类号： A61K31/66 , A61P37/02 , C07C237/00 , C07F9/09
CPC分类号： C07C237/22 , C07C235/10 , C07F9/091 , C07K5/02 , C07K5/06191
摘要： Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals.
摘要翻译： 下式的化合物，其中取代基在本说明书中定义可用于调节温血动物中的免疫应答。
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3.发明申请Novel Compounds of the Family of Iminosugars, Uses Thereof for Trewating Lysosomal Diseases, and Method for Preparing Same 审中-公开亚氨基糖苷家族的新型化合物，其用于启动溶酶体疾病的用途及其制备方法公开(公告)号：US20080269285A1
公开(公告)日：2008-10-30
申请号：US11993880
申请日：2006-06-22
IPC分类号： A61K31/45 , C07D211/46 , A61P43/00
CPC分类号： A61K31/445 , C07D211/46
摘要： The invention concerns the use of a compound of general formula (I) wherein: R0 represents in particular a hydrogen atom or an alkyl group; R1 represents in particular a hydrogen atom or an alkyl group; R2, R3 and R4 represent in particular, independently of one another, a hydrogen atom, a hydroxyl group, an alkoxy group or an acyloxy group, for preparing a medicine for treating lysosomal diseases related to a dysfunction of at least one lysosomal glycosidase enzyme.
摘要翻译： 本发明涉及通式（I）的化合物的用途，其中：R 0表示特别是氢原子或烷基; R 1特别表示氢原子或烷基; R 2，R 3和R 4特别是彼此独立地表示氢原子，羟基，烷氧基或 用于制备用于治疗与至少一种溶酶体糖苷酶的功能障碍相关的溶酶体疾病的药物的酰氧基。
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