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1.发明申请Novel Compounds of the Family of Iminosugars, Uses Thereof for Trewating Lysosomal Diseases, and Method for Preparing Same 审中-公开亚氨基糖苷家族的新型化合物，其用于启动溶酶体疾病的用途及其制备方法公开(公告)号：US20080269285A1
公开(公告)日：2008-10-30
申请号：US11993880
申请日：2006-06-22
IPC分类号： A61K31/45 , C07D211/46 , A61P43/00
CPC分类号： A61K31/445 , C07D211/46
摘要： The invention concerns the use of a compound of general formula (I) wherein: R0 represents in particular a hydrogen atom or an alkyl group; R1 represents in particular a hydrogen atom or an alkyl group; R2, R3 and R4 represent in particular, independently of one another, a hydrogen atom, a hydroxyl group, an alkoxy group or an acyloxy group, for preparing a medicine for treating lysosomal diseases related to a dysfunction of at least one lysosomal glycosidase enzyme.
摘要翻译： 本发明涉及通式（I）的化合物的用途，其中：R 0表示特别是氢原子或烷基; R 1特别表示氢原子或烷基; R 2，R 3和R 4特别是彼此独立地表示氢原子，羟基，烷氧基或 用于制备用于治疗与至少一种溶酶体糖苷酶的功能障碍相关的溶酶体疾病的药物的酰氧基。
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公开(公告)号：US20090301875A1
公开(公告)日：2009-12-10
申请号：US12497610
申请日：2009-07-03
申请人： Yongxian Wu , Bun-Ichiro Nakajima , Shinji Takeda , Iwao Fukuchi , Naoki Asano
发明人： Yongxian Wu , Bun-Ichiro Nakajima , Shinji Takeda , Iwao Fukuchi , Naoki Asano
CPC分类号： H01B1/122 , G01N27/406
摘要： An ionic polymer composite device and methods for fabricating the ionic polymer composite device are provided. The ionic polymer composite device includes two extended electrode layers, each extended electrode layer including at least one ionic polymer with a plurality of electrically conductive particles, and a dielectric layer including at least one sulfonated poly ether sulfone polymer or a derivative between the two extended electrode layers.
摘要翻译： 提供一种离子聚合物复合器件和用于制造离子聚合物复合器件的方法。 离子聚合物复合器件包括两个延伸的电极层，每个延伸的电极层包括至少一种具有多个导电颗粒的离子聚合物，以及包含至少一种磺化聚醚砜聚合物或两个延伸电极之间的衍生物的介电层 层。
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公开(公告)号：US06916829B2
公开(公告)日：2005-07-12
申请号：US10304395
申请日：2002-11-26
申请人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
发明人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
IPC分类号： A61K31/445 , A61K31/4465 , A61K31/7008 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61P43/00 , C07D207/12 , C07D211/46 , C07H17/02 , C12N9/40 , A61K31/435 , A61K31/70
CPC分类号： A61K31/445 , A61K31/70 , A61K31/7008 , C07D451/06 , C12N9/2465
摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.
摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸组合物对于增强葡糖脑苷脂酶活性是有效的。
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公开(公告)号：US07812033B2
公开(公告)日：2010-10-12
申请号：US11528903
申请日：2006-09-27
申请人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
发明人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/70 , A61K31/7008 , C07D451/06 , C12N9/2465
摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.
摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸组合物对于增强葡糖脑苷脂酶活性是有效的。
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5.发明申请BLOCK COPOLYMER, AND POLYMER ELECTROLYTE, POLYMER ELECTROLYTE MEMBRANE, MEMBRANE ELECTRODE ASSEMBLY AND FUEL CELL USING SAME 审中-公开嵌段共聚物和聚合物电解质，聚合物电解质膜，膜电极组件和使用它的燃料电池公开(公告)号：US20100209813A1
公开(公告)日：2010-08-19
申请号：US12707094
申请日：2010-02-17
申请人： Atsuhiko ONUMA , Makoto Morishima , Naoki Asano
发明人： Atsuhiko ONUMA , Makoto Morishima , Naoki Asano
CPC分类号： C08J5/2256 , C08G65/4056 , C08G75/0227 , C08G75/0245 , C08G75/23 , C08J2371/12 , C08J2381/06 , C08L2205/05 , H01M8/1025 , H01M8/1027 , H01M8/1032
摘要： A polymer electrolyte for a fuel cell is provided at low cost which has excellent mechanical characteristics, resistance to oxidation and high ion conductivity, and which hardly swells.The polymer electrolyte includes a block copolymer containing a hydrophilic segment and a hydrophobic segment. The hydrophilic segment contains a structural unit represented by the following chemical formula (1).
摘要翻译： 以低成本提供燃料电池用高分子电解质，其具有优异的机械特性，耐氧化性和高离子传导性，并且几乎不溶胀。 聚合物电解质包含含有亲水链段和疏水链段的嵌段共聚物。 亲水性片段含有由以下化学式（1）表示的结构单元。
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公开(公告)号：US20070021381A1
公开(公告)日：2007-01-25
申请号：US11528903
申请日：2006-09-27
申请人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
发明人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
IPC分类号： A61K31/7008 , A61K31/445
CPC分类号： A61K31/445 , A61K31/70 , A61K31/7008 , C07D451/06 , C12N9/2465
摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.
摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸组合物对于增强葡糖脑苷脂酶活性是有效的。
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公开(公告)号：US5603618A
公开(公告)日：1997-02-18
申请号：US265136
申请日：1994-06-24
CPC分类号： H05K7/1418
摘要： A device for attaching and detaching a mounting board unit with respect to a device body in a substantially vertical posture includes a controller base which has a detachable mounting board fixed thereto and a guide portion engaging a guide rail provided on the device body. The guide portion guides the controller base when the mounting board unit is attached to and detached from the device body. Mounting boards having different shapes can be mounted on the unit of the same construction, and even a mounting board on which a heavy device such as a hard disk is mounted can be easily attached to and detached from the device body in a vertically arranged condition.
摘要翻译： 用于以大致垂直姿势相对于装置主体安装和拆卸安装板单元的装置包括：控制器基座，其具有固定到其上的可拆卸安装板和与设置在装置主体上的导轨接合的引导部。 当安装板单元附接到设备主体并从设备主体拆卸时，引导部引导控制器基座。 具有不同形状的安装板可以安装在相同结构的单元上，并且甚至安装诸如硬盘的重型装置的安装板也可以在垂直布置的状态下容易地附接到装置主体并从装置主体拆卸。
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公开(公告)号：US5579098A
公开(公告)日：1996-11-26
申请号：US345346
申请日：1994-11-21
CPC分类号： G03G15/2064 , G03G21/1633 , G03G21/1652 , G03G21/1685 , G03G2215/00544 , G03G2215/00586 , G03G2221/1639 , G03G2221/1687 , G03G2221/18
摘要： An image forming apparatus having a pressing unit for pressing a fixing unit so that the fixing unit is secured to the apparatus body by the pressing force of the pressing unit. A projection portion on the fixing unit and an insertion slit in the apparatus body also secure the fixing unit, and thus, screws for securing the fixing unit to the apparatus body can be omitted and the fixing unit can easily be attached/detached. A discharge cover is rotatably mounted to the apparatus body and the fixing unit is inserted through an opening portion created when the discharge cover is opened.
摘要翻译： 一种图像形成设备，具有用于按压定影单元的按压单元，使得定影单元通过按压单元的按压力固定到设备主体。 定影单元上的突出部分和设备主体中的插入狭缝也固定固定单元，因此可以省略用于将定影单元固定到设备主体上的螺钉，并且可以容易地安装/拆卸定影单元。 排出盖可旋转地安装在装置主体上，固定单元插入通过打开排出盖时形成的开口部分。
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9.发明授权
公开(公告)号：US5465141A
公开(公告)日：1995-11-07
申请号：US865242
申请日：1992-04-08
申请人： Naoki Asano , Yutaka Kikuchi , Yasuyoshi Hayakawa
发明人： Naoki Asano , Yutaka Kikuchi , Yasuyoshi Hayakawa
CPC分类号： G03G15/2003 , G03G15/2039 , G03G15/2042
摘要： A fixing apparatus having a heating member maintained at a predetermined fixing temperature and an electric supply device for supplying an electric current to the heating member, wherein the electric supply device supplies an electric current at a second duty cycle larger than a first duty cycle after an electric current is supplied at the first duty cycle from the time the supply of the electric current is started to the heating member until a fixing temperature is reached.
摘要翻译： 具有保持在预定定影温度的加热构件的定影装置和用于向加热构件供应电流的供电装置，其中，电源装置在大于第一占空比的第二占空比之后提供电流， 从开始供电到加热构件直至定影温度达到第一占空比时，供给电流。
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公开(公告)号：US08436018B2
公开(公告)日：2013-05-07
申请号：US12890014
申请日：2010-09-24
申请人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
发明人： Jian-Qiang Fan , Satoshi Ishii , Naoki Asano
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/70 , A61K31/7008 , C07D451/06 , C12N9/2465
摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.
摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸化合物对增强葡糖脑苷脂酶活性是有效的。
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