公开(公告)号：US20100148063A1

公开(公告)日：2010-06-17

申请号：US12710245

申请日：2010-02-22

申请人： Jae C. SCHWARTZ ,  John E.P. Syka ,  Scott T. Quarmby

发明人： Jae C. SCHWARTZ ,  John E.P. Syka ,  Scott T. Quarmby

IPC分类号： H01J49/26

CPC分类号： H01J49/0418 ,  H01J49/0045 ,  H01J49/0404 ,  H01J49/4225

摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.

摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。

公开(公告)号：US20080142705A1

公开(公告)日：2008-06-19

申请号：US11639273

申请日：2006-12-13

申请人： Jae C. Schwartz ,  John E.P. Syka ,  Scott T. Quarmby

发明人： Jae C. Schwartz ,  John E.P. Syka ,  Scott T. Quarmby

IPC分类号： H01J49/26

CPC分类号： H01J49/0418 ,  H01J49/0045 ,  H01J49/0404 ,  H01J49/4225

摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.

摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。

公开(公告)号：US20120156792A1

公开(公告)日：2012-06-21

申请号：US13391331

申请日：2010-09-02

申请人： John E.P. Syka ,  Philip D. Compton ,  Donald F. Hunt

发明人： John E.P. Syka ,  Philip D. Compton ,  Donald F. Hunt

IPC分类号： G01N27/62

CPC分类号： H01J49/0072 ,  Y10T436/24

摘要： The invention provides improvements in reagents for use in electron transfer dissociation ionization techniques for use in mass spectrometry, particularly for sequencing peptides and proteins using mass spectrometric techniques involving electro-spray ionization and MS/MS characterization of fragment ions. The novel reagents used in the inventive methods allow for more effective determination of protein sequences, especially of long peptides or post-translationally modified protein fragments. Use of the polycyclic aromatic hydrocarbons azulene, homoazulene, and acenaphthylene, and homodimers and heterodimers thereof, are described.

摘要翻译： 本发明提供了用于电子转移离解电离技术用于质谱法的试剂的改进，特别是使用涉及电喷雾电离和片段离子的MS / MS表征的质谱技术测序肽和蛋白质。 用于本发明方法的新颖试剂允许更有效地测定蛋白质序列，特别是长肽或翻译后修饰的蛋白质片段。 描述了多环芳香烃薁，高ene烯和苊烯及其同二聚体和异二聚体的用途。