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1.发明授权公开(公告)号：US08278620B2
公开(公告)日：2012-10-02
申请号：US12772875
申请日：2010-05-03
申请人： Jae C. Schwartz , Philip M. Remes
发明人： Jae C. Schwartz , Philip M. Remes
IPC分类号： B01D59/44
CPC分类号： H01J49/0009 , H01J49/0045
摘要： A method of calibrating ion collision energy used in a mass spectrometer, comprises: (a) obtaining fragment ion yield data for each of a plurality of precursor ion populations having respective mass-to-charge ratios at each of a plurality of settings of a fragmentation-energy-related variable; (b) locating, for each mass-to-charge ratio, reference values of the fragmentation-energy-related variable, each reference value corresponding to a respective reference feature of the ion yield data at the mass-to-charge ratio; (c) determining, from the plurality of locating steps, the variation, with mass-to-charge-ratio, of each of the reference values of the fragmentation-energy-related variable; (d) associating each of the reference values of the fragmentation-energy related variable with respective reference values of a dimensionless useable-fragmentation-energy variable; and (e) storing parameters describing the variation of each of the reference values of the fragmentation-energy-related variable with mass-to-charge ratio, wherein the parameters comprise coefficients of at least one non-linear equation.
摘要翻译： 一种校准在质谱仪中使用的离子碰撞能量的方法包括：（a）获得碎片离子产生数据，其中多个前体离子群体中的每一个在碎片化的多个设置中的每一个处具有各自的质荷比 能量相关变量; （b）对于每个质荷比，将所述碎裂能量相关变量的参考值定位，每个参考值对应于质荷比的离子产量数据的相应参考特征; （c）从所述多个定位步骤中确定所述碎裂能量相关变量的每个参考值的质量与电荷比的变化; （d）将碎裂能相关变量的每个参考值与无量纲可分段能量变量的相应参考值相关联; 以及（e）存储描述所述碎裂能量相关变量的每个参考值的变化与质荷比的参数，其中所述参数包括至少一个非线性方程式的系数。
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公开(公告)号：US08168943B2
公开(公告)日：2012-05-01
申请号：US11845723
申请日：2007-08-27
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0045
摘要： Methods and apparatus for data-dependent mass spectrometric MS/MS or MSn analysis are disclosed. The methods may include determination of the charge state of an ion species of interest, followed by automated selection of a dissociation type (e.g., CAD, ETD, or ETD followed by a non-dissociative charge reduction or collisional activation) based at least partially on the determined charge state. The ion species of interest is then dissociated in accordance with the selected dissociation type, and an MS/MS or MSn spectrum of the resultant product ions may be acquired.
摘要翻译： 公开了数据依赖质谱MS / MS或MSn分析的方法和装置。 所述方法可以包括确定感兴趣的离子物质的电荷状态，然后至少部分地基于自由选择解离型（例如，CAD，ETD或ETD，随后是非解离电荷减少或碰撞激活） 确定的充电状态。 然后根据选择的解离型解离感兴趣的离子种类，并且可以获得所得产物离子的MS / MS或MSn光谱。
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公开(公告)号：US07928373B2
公开(公告)日：2011-04-19
申请号：US11713210
申请日：2007-03-02
IPC分类号： H01J48/42
CPC分类号： H01J49/427
摘要： Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). The ejection waveforms have frequency components in a first and a second dimension, and, are applied across electrodes aligned along a first and a second dimension. Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the number of frequency components.
摘要翻译： 通过调整场和使用喷射频率波形，在离子阱中隔离预定义的窄质量与电荷比范围内的离子。 喷射波形具有第一和第二维度的频率分量，并且沿着沿第一和第二维度排列的电极施加。 因此，质量 - 电荷比隔离窗口被控制并且具有改进的分辨率而不增加频率分量的数量。
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4.发明申请Ion Population Control in a Mass Spectrometer Having Mass-Selective Transfer Optics 有权具有质量选择性转移光学质谱仪的离子人口控制公开(公告)号：US20100282957A1
公开(公告)日：2010-11-11
申请号：US12777088
申请日：2010-05-10
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/065
摘要： Methods for operating a mass spectrometer having at least one component having mass-dependent transmission, comprising: injecting a first sample of ions having a first mass range into an ion accumulator for a first injection time under first operating conditions suitable for optimizing transmission of ions of the first range; acquiring a full-scan mass spectrum of the first sample of ions; selecting ion species having a second mass range different than the first range; calculating a second injection time, the second injection time suitable for injecting a population of the selected ion species into the ion accumulator under second operating conditions suitable for optimizing transmission of ions of the second range; injecting a second sample of ions having the selected ion species into the ion accumulator for the second injection time under the second operating conditions; and acquiring a mass spectrum of ions derived from the selected ion species.
摘要翻译： 用于操作具有至少一种具有质量依赖透射率的组分的质谱仪的方法包括：在适于优化离子的透射的第一操作条件下，将具有第一质量范围的离子的第一样品注入离子蓄积器中用于第一注入时间 第一范围; 获取第一离子样品的全扫描质谱; 选择具有不同于所述第一范围的第二质量范围的离子物质; 计算第二注射时间，所述第二注射时间适合于在适于优化所述第二范围的离子的透射的第二操作条件下将所选择的离子物质的群体注入到所述离子蓄积器中; 在第二操作条件下将具有所选择的离子种类的离子的第二样品注入到离子蓄积器中用于第二注入时间; 并获取从所选择的离子种类衍生的离子的质谱。
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5.发明申请Methods of Calibrating and Operating an Ion Trap Mass Analyzer to Optimize Mass Spectral Peak Characteristics 有权校准和操作离子阱质谱分析仪以优化质谱峰特征的方法公开(公告)号：US20100059666A1
公开(公告)日：2010-03-11
申请号：US12205624
申请日：2008-09-05
申请人： Philip M. Remes , Jae C. Schwartz
发明人： Philip M. Remes , Jae C. Schwartz
CPC分类号： H01J49/0009 , H01J49/423 , H01J49/427
摘要： A method for calibrating an ion trap mass spectrometer is disclosed. The method includes steps of identifying a phase (defined by the RF trapping and resonant ejection voltages) that optimizes peak characteristics, and then determining, for each of a plurality of calibrant ions, an optimal resonant ejection voltage amplitude when the ion trap is operated at the identified phase. The resonant ejection voltage applied to the electrodes of the ion trap may then be controlled during analytical scans in accordance with the established relationship between m/z and resonant ejection voltage amplitude.
摘要翻译： 公开了一种校准离子阱质谱仪的方法。 该方法包括以下步骤：识别优化峰值特性的相位（由RF捕获和共振喷射电压定义），然后对于多个校准离子中的每一个确定当离子阱操作时的最佳共振喷射电压振幅 确定阶段。 然后可以根据建立的m / z和共振喷射电压振幅之间的关系在分析扫描期间控制施加到离子阱的电极的共振喷射电压。
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公开(公告)号：US07534998B2
公开(公告)日：2009-05-19
申请号：US12050116
申请日：2008-03-17
申请人： Jae C. Schwartz
发明人： Jae C. Schwartz
IPC分类号： H01J49/42
CPC分类号： H01J49/423
摘要： A system and method are disclosed for effectively compensating for an unbalanced or non-zero centerline radio-frequency potential in a quadrupolar ion trap, the unbalanced centerline potential created by a compensation feature that minimizes non-linear field components created by one or more ejection slots in the ion trap. The ion trap includes a centerline that passes longitudinally through a trapping volume inside of the ion trap, a pair of Y electrodes with inner Y electrode surfaces that are approximately parallel to the centerline, and a pair of X electrodes with inner X electrode surfaces that are approximately parallel to the centerline. The X electrodes have ejection slots through which trapped ions are ejected from the ion trap. A Y signal with a Y signal amplitude is coupled to both of the Y electrodes. An X signal with an X signal amplitude is coupled to both of the X electrodes. The X signal amplitude is selected to be greater than the Y signal amplitude to thereby create a balanced centerline potential at the centerline of the ion trap device.
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公开(公告)号：US07456396B2
公开(公告)日：2008-11-25
申请号：US10922809
申请日：2004-08-19
IPC分类号： H01J49/42
CPC分类号： H01J49/427
摘要： Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the number of frequency components.
摘要翻译： 通过调整场和使用喷射频率波形，在离子阱中隔离预定义的窄质量与电荷比范围内的离子。 因此，质量 - 电荷比隔离窗口被控制并且具有改进的分辨率而不增加频率分量的数量。
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公开(公告)号：US07425699B2
公开(公告)日：2008-09-16
申请号：US11832596
申请日：2007-08-01
CPC分类号： H01J49/4225 , G01N27/62 , H01J49/425
摘要： A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and passed to a linear trap 30. Ions are trapped in a potential well in the linear trap 30 and are bunched at the bottom of the potential well adjacent an exit segment 50. Ions are gated out of the linear trap 30 into an electrostatic ion trap 130 and are detected by a secondary electron multiplier 10. By bunching the ions in the linear trap 30 prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap 130, the ions arrive at the electrostatic trap 130 as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.
摘要翻译： 质谱仪10包括产生经由离子源块16进入离子冷却器20的雾化离子的离子源12。 通过四极质量过滤器24提取感兴趣的m / z窗口内的离子，并将其传递到线性阱30中。离子被捕获在线性阱30中的势阱中，并且在与潜在井相邻的势阱的底部聚集 离子区域从线性阱30门控进入静电离子阱130中，并由二次电子倍增器10检测。通过在排出之前聚集线性阱30中的离子，并且通过在 飞行（TOF）在静电捕获器130的入口处，离子以类似m / z的短能量分组的卷积到达静电捕获器130。 由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。
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9.发明申请System and Method for Implementing Balanced RF Fields in an Ion Trap Device 有权用于在离子阱装置中实现平衡RF场的系统和方法公开(公告)号：US20080156986A1
公开(公告)日：2008-07-03
申请号：US12050116
申请日：2008-03-17
申请人： Jae C. Schwartz
发明人： Jae C. Schwartz
IPC分类号： H01J49/00
CPC分类号： H01J49/423
摘要： A system and method are disclosed for effectively compensating for an unbalanced or non-zero centerline radio-frequency potential in a quadrupolar ion trap, the unbalanced centerline potential created by a compensation feature that minimizes non-linear field components created by one or more ejection slots in the ion trap. The ion trap includes a centerline that passes longitudinally through a trapping volume inside of the ion trap, a pair of Y electrodes with inner Y electrode surfaces that are approximately parallel to the centerline, and a pair of X electrodes with inner X electrode surfaces that are approximately parallel to the centerline. The X electrodes have ejection slots through which trapped ions are ejected from the ion trap. A Y signal with a Y signal amplitude is coupled to both of the Y electrodes. An X signal with an X signal amplitude is coupled to both of the X electrodes. The X signal amplitude is selected to be greater than the Y signal amplitude to thereby create a balanced centerline potential at the centerline of the ion trap device.
摘要翻译： 公开了一种用于有效地补偿四极离子阱中的不平衡或非零中心线射频电位的系统和方法，由补偿特征产生的不平衡中心线电位使得由一个或多个喷射槽产生的非线性场分量最小化 在离子阱中。 离子阱包括纵向穿过离子阱内的捕获体积的中心线，具有大致平行于中心线的内部Y电极表面的一对Y电极，以及具有内部X电极表面的一对X电极， 大致平行于中心线。 X电极具有从离子阱排出被捕获的离子的喷射槽。 具有Y信号幅度的Y信号耦合到两个Y电极。 具有X信号振幅的X信号被耦合到两个X电极。 选择X信号幅度大于Y信号幅度，从而在离子阱装置的中心线处产生平衡的中心线电位。
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公开(公告)号：US06872938B2
公开(公告)日：2005-03-29
申请号：US10472917
申请日：2002-03-20
CPC分类号： H01J49/4225 , B82Y30/00 , H01J49/423 , H01J49/425
摘要： A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and passed to a linear trap 30. Ions are trapped in a potential well in the linear trap 30 and are bunched at the bottom of the potential well adjacent an exit segment 50. Ions are gated out of the linear trap 30 into an electrostatic ion trap 130 and are detected by a secondary electron multiplier 10. By bunching the ions in the linear trap 30 prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap 130, the ions arrive at the electrostatic trap 130 as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.
摘要翻译： 质谱仪10包括离子源12，其产生经由离子源块16进入离子冷却器20的雾化离子。感兴趣的m / z窗口内的离子通过四极质量过滤器24提取并传递到线性阱 离子被捕获在线性阱30中的势阱中，并且在靠近出口段50的势阱的底部聚集。离子从门极捕获器30中门控成静电离子阱130，并由 二次电子倍增器10.通过在排出之前将线性阱30中的离子聚束，并且通过在静电捕获器130的入口处聚焦于飞行时间（TOF）时的离子，离子作为卷积到达静电捕获器130 短的，精力充沛的类似m / z的包。 由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。
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