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    Ion analyzer
    2.
    发明授权
    Ion analyzer 有权

    公开(公告)号：US11908671B2

    公开(公告)日：2024-02-20

    申请号：US17599136

    申请日：2019-04-02

    申请人： SHIMADZU CORPORATION ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

    发明人： Hidenori Takahashi ,  Daiki Asakawa

    IPC分类号： H01J49/00 ,  H01J49/06

    CPC分类号： H01J49/0072 ,  H01J49/068

    摘要： An ion analyzer includes a reaction chamber into which precursor ions derived from a sample component are introduced, a radical irradiation unit that generates and emits a predetermined type of radicals, a standard substance supply unit that individually supplies kinds of standard substances to the reaction chamber, where activation energy of radical addition reaction is known for each of the kinds of standard substances, and the activation energies are different in magnitude, an ion measurement unit that measures an amount of predetermined product ions generated from precursor ions derived from the standard substance by irradiation with the radicals, and a radical temperature calculation unit that obtains an amount of radicals that caused the radical addition reaction from the amount of the predetermined product ions and obtains a radical temperature based on a relationship between the amount of the radicals obtained for each kind of standard substance and activation energy.

    MASS SPECTROMETRY METHOD AND MASS SPECTROMETER
    3.
    发明公开
    MASS SPECTROMETRY METHOD AND MASS SPECTROMETER 审中-公开

    公开(公告)号：US20240030016A1

    公开(公告)日：2024-01-25

    申请号：US18028931

    申请日：2021-07-30

    申请人： SHIMADZU CORPORATION

    发明人： Hidenori TAKAHASHI ,  Shinichi YAMAGUCHI

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0072 ,  H01J49/005 ,  H01J49/0031

    摘要： A mass spectrometer including: a reaction chamber into which a precursor ion derived from a sample molecule is introduced; a collision gas supply part configured to supply collision gas to the reaction chamber; a radical supply part configured to supply hydrogen radicals, oxygen radicals, nitrogen radicals, or hydroxyl radicals to the reaction chamber; a dissociation operation control part configured to control operations of the collision gas supply part and the radical supply part to generate the product ions by collision-induced dissociation and radical attachment dissociation of the precursor ion inside the reaction chamber, an ion detection part configured to mass-separate and detect ions ejected from the reaction chamber, and a spectrum data generation part configured to generate spectrum data based on a detection result by the ion detection part.

    Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
    6.
    发明授权
    Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences 有权

    公开(公告)号：US09991103B2

    公开(公告)日：2018-06-05

    申请号：US15305502

    申请日：2015-04-23

    申请人： MICROMASS UK LIMITED

    发明人： Jeffery Brown

    IPC分类号： G01D18/00 ,  G12B13/00 ,  H01J49/00

    CPC分类号： H01J49/0009 ,  H01J49/0072

    摘要： A method of checking or adjusting the calibration of a mass spectrometer is disclosed. The method comprises fragmenting parent or precursor ions and generating fragment or product ion mass spectral data and recognizing first neutral loss ions in the fragment or product ion mass spectral data. The method further comprises determining a first mass loss difference between the parent or precursor ions and the first neutral loss ions and determining whether the first mass loss difference corresponds with an expected or pre-determined mass loss difference, wherein if it is determined that the first mass loss difference does not correspond with an expected or pre-determined mass loss difference then the method further comprises adjusting one or more calibration parameters.

    MS/MS analysis using ECD or ETD fragmentation
    7.
    发明授权
    MS/MS analysis using ECD or ETD fragmentation 有权

    公开(公告)号：US09892896B2

    公开(公告)日：2018-02-13

    申请号：US15028202

    申请日：2014-10-09

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown

    IPC分类号： H01J49/00 ,  H01J49/16

    CPC分类号： H01J49/0072 ,  H01J49/0054 ,  H01J49/164

    摘要： A method of mass spectrometry is disclosed comprising: providing supercharged analyte ions; and supplying electrons or reagent ions to said analyte ions so as to transfer charge from said reagent ions or electrons to said analyte ions, said transfer of charge causing at least some of said analyte ions to dissociate. The charge transfer step is performed at a relatively high pressure and preferably substantially at atmospheric pressure.