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1.发明申请TRIAZANONANE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR ENHANCED FLUORINE-18 LABELING 有权三氯苯胺衍生物或药物可接受的盐，用于增强荧光素-18标记公开(公告)号：US20130317196A1
公开(公告)日：2013-11-28
申请号：US13983053
申请日：2012-02-01
申请人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
IPC分类号： C07D255/02 , A61K51/04 , C07K7/64
CPC分类号： C07D255/02 , A61K51/044 , C07K7/64
摘要： The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.)
摘要翻译： 本发明涉及由下述化学式1表示的三氮代壬烷衍生物或其药学上可接受的盐及其制备方法，本发明的三氮代烷衍生物与金属氟化物形成络合物，并显示出 当标记F-18时，将标记效率提高至78-90％，从而可用于各种放射性药物标记（化学式1，R1，R2，AE X，n和m如本说明书中所定义） 。）
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2.发明授权Triazanonane derivatives or pharmaceutically acceptable salt thereof for enhanced fluorine-18 labeling 有权三唑烷衍生物或其药学上可接受的盐，用于增强氟-18标记公开(公告)号：US09012604B2
公开(公告)日：2015-04-21
申请号：US13983053
申请日：2012-02-01
申请人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June-Key Chung , Myung Chul Lee
CPC分类号： C07D255/02 , A61K51/044 , C07K7/64
摘要： The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.)
摘要翻译： 本发明涉及由下述化学式1表示的三氮代壬烷衍生物或其药学上可接受的盐及其制备方法，本发明的三氮代烷衍生物与金属氟化物形成络合物，并显示出 当标记F-18时，将标记效率提高至78-90％，从而可用于各种放射性药物标记（化学式1，R1，R2，AE X，n和m如本说明书中所定义） 。）
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3.发明申请HETEROCYCLE-AMINO ACID DERIVATIVES FOR TARGETING CANCER TISSUE AND RADIOACTIVE OR NON-RADIOACTIVE LABELED COMPOUNDS THEREOF 审中-公开用于靶向癌组织和放射性或非放射性标记化合物的杂合氨基酸衍生物公开(公告)号：US20120029177A1
公开(公告)日：2012-02-02
申请号：US13262043
申请日：2010-03-31
申请人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June Key Chung , Myung Chul Lee
发明人： Jae Min Jeong , Dinesh Shetty , Dong Soo Lee , June Key Chung , Myung Chul Lee
IPC分类号： C07D255/02 , C07F1/08 , C07F5/00 , C07F13/00 , C07F15/04 , C07F15/06 , C07F17/00 , C07F11/00 , C07D257/02 , C07F15/02
CPC分类号： C07F13/005 , C07D255/02 , C07D257/02
摘要： The present invention relates to novel amino acid derivatives containing heterocyclic chelating residues thereof; radioactive or nonradioactive metal complexes thereof; methods for preparation thereof; and apyrogenic and sterile preparative kits of the composition for targeting cancer cells.The compounds of the present invention can easily be taken up to cancer cells as they contain amino acid residues thereof; radioactive or nonradioactive metals can be labeled easily as they contain heterocyclic chelating residues thereof; cancer lesion can be imaged easily by targeting using the present invention.
摘要翻译： 本发明涉及含有杂环螯合残基的新型氨基酸衍生物; 放射性或非放射性的金属络合物; 制备方法; 以及用于靶向癌细胞的组合物的致神经和无菌制备试剂盒。 本发明的化合物可容易地被摄入癌细胞，因为它们含有氨基酸残基; 放射性或非放射性金属可以容易地标记，因为它们含有杂环螯合残基; 可以通过使用本发明的靶向容易地成像癌症病变。
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