公开(公告)号：US20090234140A1

公开(公告)日：2009-09-17

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。

公开(公告)号：US07767832B2

公开(公告)日：2010-08-03

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/06

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。

公开(公告)号：US09185677B2

公开(公告)日：2015-11-10

申请号：US13867777

申请日：2013-04-22

申请人： Chae Hwan Cho ,  Song Man Lee ,  Suk Yon Kang ,  Ji Min Kim ,  Chun Young Kim

发明人： Chae Hwan Cho ,  Song Man Lee ,  Suk Yon Kang ,  Ji Min Kim ,  Chun Young Kim

IPC分类号： H04W64/00 ,  G01S5/02

CPC分类号： H04W64/003 ,  G01S5/0242 ,  G01S5/0252

摘要： The present disclosure provides a system, device and method for estimating an AP location using log data. Information, which is not pre-stored in a database when the information is updated, is classified and then location information of an AP is estimated by using log data of a user in such a manner of estimating a location of the AP by using log data of a user in wireless LAN based positioning and thus updating the database for the wireless LAN based positioning, thereby improving positioning accuracy.

摘要翻译： 本公开提供了一种使用日志数据来估计AP位置的系统，设备和方法。 当信息被更新时，不预先存储在数据库中的信息被分类，然后通过使用用户的日志数据以通过使用日志数据估计AP的位置的方式来估计AP的位置信息 的用户进行无线LAN定位，从而更新用于基于无线LAN的定位的数据库，从而提高定位精度。

公开(公告)号：US09173057B2

公开(公告)日：2015-10-27

申请号：US13867825

申请日：2013-04-22

申请人： Chae Hwan Cho ,  Suk Yon Kang ,  Song Man Lee ,  Ji Min Kim ,  Chun Young Kim

发明人： Chae Hwan Cho ,  Suk Yon Kang ,  Song Man Lee ,  Ji Min Kim ,  Chun Young Kim

IPC分类号： H04W4/02 ,  H04W64/00 ,  G01S5/02 ,  H04W48/16

CPC分类号： H04W4/02 ,  G01S5/0252 ,  H04W48/16 ,  H04W64/00

摘要： The present disclosure relates to providing a positioning service by managing a plurality of peripheral wireless LAN signals. The positioning service system collects peripheral wireless LAN radio signals by scanning peripheral access points (APs), stores AP information of each of peripheral wireless LAN radio signals in each lattice cell of a database. When a positioning request signal is received from a terminal, a positioning server of the positioning service extracts AP identification information from included in the peripheral wireless LAN radio signal received from the terminal. By using the extracted AP identification information, the positioning server selects from the database the corresponding lattice cell matching to the stored AP identification information of each of the peripheral wireless LAN radio signals pre-stored. And the positioning server estimates location information of the selected corresponding lattice cell as location information for the terminal.

摘要翻译： 本公开涉及通过管理多个外围无线LAN信号来提供定位服务。 定位服务系统通过扫描外围接入点（AP）来收集外围无线LAN无线电信号，将每个外围无线LAN无线电信号的AP信息存储在数据库的每个格子单元中。 当从终端接收到定位请求信号时，定位服务的定位服务器从包括在从终端接收的外围无线LAN无线电信号中提取AP识别信息。 通过使用提取的AP识别信息，定位服务器从数据库中选择与存储的每个外围无线LAN无线电信号的存储的AP标识信息匹配的对应的格子单元。 并且定位服务器估计所选择的相应格子单元的位置信息作为终端的位置信息。