公开(公告)号：US20050009765A1

公开(公告)日：2005-01-13

申请号：US10496275

申请日：2001-12-05

申请人： Jaehoon Yu ,  Jongkook Lee ,  Miyun Kwon ,  Kye-Jung Shin

发明人： Jaehoon Yu ,  Jongkook Lee ,  Miyun Kwon ,  Kye-Jung Shin

IPC分类号： C07H5/10 ,  C07H15/232 ,  A61K31/704 ,  C07H15/20 ,  C07H15/22

CPC分类号： C07H5/10 ,  C07H15/232

摘要： The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol of formula 1, their preparation and their use. Because of their heterodimeric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, the can be effectively used as an antiviral agent, an antibacterial agent or an anti cancer drugs.

摘要翻译： 本发明涉及式1的新霉素 - 氯霉素的异二聚体缀合物，其制备及其用途。 由于它们的异二聚体结构，它们可以识别RNA基序的茎和环，并且显示出对某些RNA的结合能力，使得它们具有增强的药物功效并且可以由非特异性药物引起的副作用降低。 由于这些原因，可以有效地用作抗病毒剂，抗菌剂或抗癌药物。

公开(公告)号：US07022839B2

公开(公告)日：2006-04-04

申请号：US10496275

申请日：2001-12-05

申请人： Jaehoon Yu ,  Jongkook Lee ,  Miyun Kwon ,  Kye-Jung Shin

发明人： Jaehoon Yu ,  Jongkook Lee ,  Miyun Kwon ,  Kye-Jung Shin

IPC分类号： C07H1/00

CPC分类号： C07H5/10 ,  C07H15/232

摘要： The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol, of formula 1, their preparation and their use. Because of their heterodmieric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, they can be effectively used as an antiviral agent, an antibacterial agent or an anticancer drugs.

摘要翻译： 本发明涉及式1的新霉素 - 氯霉素的异二聚体缀合物，其制备及其用途。 由于其异质结构，它们可以识别RNA基序的茎和环，并且显示出对某些RNA的结合能力，使得它们具有增强的药物功效并且可以由非特异性药物引起的副作用降低。 由于这些原因，它们可以有效地用作抗病毒剂，抗菌剂或抗癌药物。

公开(公告)号：US20050222055A1

公开(公告)日：2005-10-06

申请号：US10502539

申请日：2002-07-04

申请人： Jaehoon Yu ,  Jongkook Lee ,  Miyun Kwon ,  Ae Pae ,  Hun Koh

发明人： Jaehoon Yu ,  Jongkook Lee ,  Miyun Kwon ,  Ae Pae ,  Hun Koh

IPC分类号： C07H15/22 ,  C07H15/232 ,  C07H15/20 ,  A61K31/704

CPC分类号： C07H15/232

摘要： The present invention relates to novel oxazolidinone derivatives represented as following compound I and a process for the preparation thereof. The compounds of the present invention have wide antibacterial spectrums superior antibacterial activity and low toxicity. Therefore, it can be expected to use as novel antibacterial agent. wherein, R1 is alkylcarboxyl group or —CH2R2 (wherein, R2 is OH, argido group, —OR3 (wherein, R3 is C1-4 alkyl, methansulfonyl, p-toluensulfonyl, carboxyl, C1-4 alkylcarboxyl, C1-4 alkylcarbonyl, benzyloxycarbonyl, or imidazolylcarbonyl), or —NHR4).

摘要翻译： 本发明涉及以下述化合物I表示的新型恶唑烷酮衍生物及其制备方法。 本发明的化合物具有广泛的抗菌谱，抗菌活性和毒性低。 因此，可以预期用作新型抗菌剂。 其中R 1是烷基羧基或-CH 2 R 2 R 2（其中R 2是OH，argido 基团，-OR 3（其中R 3是C 1-4烷基，甲磺酰基，对甲苯磺酰基，羧基，C 1 -C 4烷基， 1-4烷基羧基，C 1-4烷基羰基，苄氧基羰基或咪唑基羰基）或-NHR 4）。

公开(公告)号：US07101841B2

公开(公告)日：2006-09-05

申请号：US10474667

申请日：2001-12-05

申请人： Jaehoon Yu ,  Miyun Kwon ,  Sunjoo Jeong

发明人： Jaehoon Yu ,  Miyun Kwon ,  Sunjoo Jeong

IPC分类号： A01N37/18 ,  A61K38/00

CPC分类号： C07K7/08

摘要： The present invention relates to carbohydrate-specific peptides, which have a strong affinity and preparation method thereof. Particularly, the present invention relates to carbohydrate-specific peptides, which have been developed to have an increased strong affinity to carbohydrates by the multiple combinations of peptides having carbohydrates-specific amino acid sequences and preparation method thereof. Carbohydrate-specific peptides of the present invention have a very strong affinity under micromol, so that they can shut off recognition between cells transferred by specific carbohydrates, which means they can be used for the treatment of diseases mediated by recognition between cells and used as a diagnostic kit which diagnoses diseases by confirming the existence of any specific carbohydrate.

摘要翻译： 本发明涉及具有很强亲和力的碳水化合物特异性肽及其制备方法。 特别地，本发明涉及通过具有碳水化合物特异性氨基酸序列的肽的多重组合对碳水化合物具有增强的强亲和力的碳水化合物特异性肽及其制备方法。 本发明的碳水化合物特异性肽在微摩尔下具有非常强的亲和力，使得它们可以切断由特定碳水化合物转移的细胞之间的识别，这意味着它们可以用于治疗由细胞之间的识别介导的疾病，并用作 通过确认任何特定碳水化合物的存在来诊断疾病的诊断试剂盒。