公开(公告)号：US20080132460A1

公开(公告)日：2008-06-05

申请号：US11871146

申请日：2007-10-11

申请人： Jaekyoon SHIN ,  Han-Woong Lee ,  Goo Taeg Oh

发明人： Jaekyoon SHIN ,  Han-Woong Lee ,  Goo Taeg Oh

IPC分类号： A61K31/70 ,  G01N33/53 ,  G01N33/574 ,  A01K67/00 ,  C12N5/06 ,  C12Q1/68 ,  C40B40/08 ,  A61P43/00

CPC分类号： C12Q1/6883 ,  A01K2217/075 ,  C07K14/4702 ,  C07K2319/60 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

摘要翻译： 该应用揭示了p62在老龄化相关疾病中的作用，如肥胖发展，2型糖尿病，非酒精性脂肪肝，各种肿瘤，男性死亡率增高，细胞内包涵体命名为后遗症和氧化还原调节。 特别地，该申请公开了一种检测神经变性疾病中包涵体形成的方法。 本发明还涉及筛选分散夹杂物的治疗剂的方法。 此外，还公开了含有p62基因突变且具有功能性破坏的p62基因座的转基因小鼠。