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    Modified polypeptides with high activity and reduced allergenicity
    3.
    发明授权
    Modified polypeptides with high activity and reduced allergenicity 失效
    具有高活性和降低变应原性的改良多肽

    公开(公告)号：US06284246B1

    公开(公告)日：2001-09-04

    申请号：US08903298

    申请日：1997-07-30

    申请人： David J. Weisgerber ,  Donn N. Rubingh

    发明人： David J. Weisgerber ,  Donn N. Rubingh

    IPC分类号： A61K600

    CPC分类号： C11D3/38627 ,  A61K8/0208 ,  A61K8/66 ,  A61K8/86 ,  A61K47/60 ,  A61K2800/57 ,  A61K2800/70 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/10 ,  C11D3/386

    摘要： The present invention relates to a modified polypeptide which has an enzymatic activity level of greater than about 70% of the parent polypeptide and an allergenic response level of less than about 33% of the parent polypeptide. Embodiments of the present invention relate to modified polypeptides with reduced allergenicity and high enzymatice activity comprising the formula: A-Bn wherein A is an enzyme, and mixtures thereof; B is a twin polymer moiety, having a total molecular weight of from about 0.5 kilodaltons (KD) to about 40 KD, having the formula conjugated to the enzyme; wherein R1 and R2 are essentially straight chain polymers, having a molecular weight ranging from about 0.25 KD to about 20 KD; wherein the ratio of the molecular weights of R1 and R2 is from about 1:10 to about 10:1; wherein X is a linking moiety which links the twin moeity to a single site on the enzyme; and n is the number of twin polymer moietis conjugated to the enzyme, and represents an integer from about 1 to about 15.

    摘要翻译： 本发明涉及一种修饰的多肽，其具有大于母体多肽的约70％的酶活性水平和低于亲本多肽的约33％的过敏反应水平。 本发明的实施方案涉及具有降低的变应原性和高酶促活性的修饰多肽，其包含下式：其中A是酶及其混合物; B是具有约0.5千道尔顿（KD）至约40KD的总分子量的双聚合物部分，具有与酶结合的结合物; 其中R1和R2基本上是直链聚合物，其分子量范围为约0.25KD至约20KD; 其中R1和R2的分子量的比例为约1:10至约10:1; 其中X是连接部分，其将双重结合连接到酶上的单个位点; 并且n是与酶缀合的双重聚合物的数目，并且表示约1至约15的整数。

    Replaceable nose assembly for chain saw guide bar
    7.
    发明授权
    Replaceable nose assembly for chain saw guide bar 失效
    链锯导向杆可更换鼻部组件

    公开(公告)号：US4561181A

    公开(公告)日：1985-12-31

    申请号：US421876

    申请日：1982-09-23

    申请人： David J. Weisgerber

    发明人： David J. Weisgerber

    IPC分类号： B27B17/02 ,  B27B17/04

    CPC分类号： B27B17/025

    摘要： A guide bar has a main body section and a separate nose section releasably secured thereto. The main body section has a pair of opposed recesses in opposite faces thereof and an opening in said recesses to form a flange. The nose section includes a pair of opposed plates, at least one of the plates having a central portion deformed laterally toward the other plate. The plates are secured together in the region of lateral deformation with edge margins thereof spaced apart to provide a drive chain-receiving groove generally aligned with a similar groove in the peripheral edge of the main body section. The body and nose sections are secured together by a hub and expander member assembly which extends into substantially aligned apertures in the body section and nose section. Edge margins of the recesses on the body section and nose section are disposed at diverging angles progressing toward the nose end of the bar to aid in alignment and securing of the body and nose section.

    摘要翻译： 导杆具有主体部分和可释放地固定到其上的单独的鼻部。 主体部分在其相对面上具有一对相对的凹槽，并且在所述凹部中具有开口以形成凸缘。 鼻部包括一对相对的板，至少一个板具有朝向另一个板横向变形的中心部分。 板在横向变形的区域中固定在一起，其边缘边缘间隔开，以提供与主体部分的周边边缘中的相似凹槽大致对准的驱动链接收槽。 主体部分和鼻部部分通过轮毂和扩张器部件组件固定在一起，该组件和扩张器部件组件延伸到主体部分和鼻部部分中的大致对齐的孔中。 主体部分和鼻部部分上的凹部的边缘设置成朝着杆的鼻端前进的发散角度，以帮助对准和固定身体和鼻部。

    Rotatable load clamp adapted for selective load positioning in response to selective rotational positioning of clamp
    8.
    发明授权
    Rotatable load clamp adapted for selective load positioning in response to selective rotational positioning of clamp 失效
    适用于响应于夹具的选择性旋转定位的选择性载荷定位的可旋转载荷夹具

    公开(公告)号：US4177000A

    公开(公告)日：1979-12-04

    申请号：US888925

    申请日：1978-03-22

    申请人： Harry F. Weinert ,  Larry D. McCart ,  David J. Weisgerber

    发明人： Harry F. Weinert ,  Larry D. McCart ,  David J. Weisgerber

    IPC分类号： B66F9/18 ,  B66C1/42

    CPC分类号： B66F9/184 ,  Y10S414/124

    摘要： A selectively rotatable load clamp for lift trucks, having a pair of openable and closable clamp arms. The clamp arms are capable of shifting the position of a load relative to the lift truck by movement of the clamp arms in unison, by which the load may be moved relative to the lift truck between a position of equal extension, wherein the forward ends of the clamp arms extend a substantially equal distance forwardly of the lift truck, and a position of unequal extension wherein the forward end of one clamp arm extends a greater distance forwardly than the forward end of the other clamp arm. The fluid motor apparatus for accomplishing such shifting function is selectively actuatable only in certain predetermined rotation positions of the clamp, that is, those positions where the two clamp arms are disposed at substantially a 45.degree. angle relative to horizontal. A valve assembly responsive to the rotational position of the clamp permits the selective actuation of the shifting function in such position, while preventing the selective opening or closing of the clamp arms. Conversely, when the clamp arms are placed either one above the other or side-by-side, the selective opening or closing of the arms is permitted while the actuation of the shifting function is prevented.

    摘要翻译： 一种用于起重车的可选择性旋转的负载夹具，具有一对可开启和关闭的夹紧臂。 夹臂能够通过夹紧臂的一致移动来移动载荷相对于起重车的位置，通过该夹臂可以在相等延伸的位置之间相对于起重车运动载荷，其中， 夹臂延伸到起重车的前方基本上相等的距离，以及不平等延伸的位置，其中一个夹臂的前端比另一夹臂的前端向前延伸更大的距离。 用于实现这种移动功能的流体马达装置仅在夹具的某些预定的旋转位置，即两个夹臂相对于水平面大致成45度的角度布置的位置可选择地启动。 响应于夹具的旋转位置的阀组件允许在该位置选择性地致动换档功能，同时防止夹紧臂的选择性打开或关闭。 相反，当夹臂被放置在另一个或并排放置时，允许选择性地打开或关闭臂，同时防止移动功能的致动。

    Sucrose polyesters which behave like cocoa butters
    10.
    发明授权
    Sucrose polyesters which behave like cocoa butters 失效
    蔗糖聚酯，其表现为可可豆

    公开(公告)号：US4822875A

    公开(公告)日：1989-04-18

    申请号：US189444

    申请日：1988-05-02

    申请人： Stephen A. McCoy ,  Bryan L. Madison ,  Peter M. Self ,  David J. Weisgerber

    发明人： Stephen A. McCoy ,  Bryan L. Madison ,  Peter M. Self ,  David J. Weisgerber

    IPC分类号： A23G1/00 ,  A23G1/38 ,  A23G1/56 ,  C11C3/04

    CPC分类号： A23G1/38 ,  A23G1/56 ,  C11C3/04 ,  A23G2200/08 ,  Y10S426/804

    摘要： The invention is a cocoa butter substitute comprising sucrose fatty acid esters having at least four fatty acid ester groups, and having the following fatty acid composition: (a) from about 25% to about 50% lauric acid; (b) from about 50% to about 75% palmitic acid; and (c) up to about 5% other fatty acids, preferably selected from the group consisting of capric, myristic, and stearic acids, and mixtures thereof. Alternatively, the cocoa butter substitute can comprise sucrose fatty acid esters having at least four fatty acid ester groups, and having the following fatty acid composition: (a) from about 25% to about 50% capric acid; (b) from about 50% to about 75% stearic acid; and (c) up to about 5% other fatty acids.The cocoa butter substitute is noncaloric and less expensive than natural cocoa butter. It has the same desirable melting properties as natural cocoa butter.

    摘要翻译： 本发明是一种可可脂替代物，其包含具有至少四个脂肪酸酯基团的蔗糖脂肪酸酯，并且具有以下脂肪酸组成：（a）约25％至约50％的月桂酸; （b）约50％至约75％的棕榈酸; 和（c）最多约5％的其它脂肪酸，优选选自癸酸，肉豆蔻酸和硬脂酸，以及它们的混合物。 或者，可可脂替代物可以包含具有至少四个脂肪酸酯基的蔗糖脂肪酸酯，并且具有以下脂肪酸组成：（a）约25％至约50％的癸酸; （b）约50％至约75％硬脂酸; 和（c）至多约5％的其他脂肪酸。 可可脂替代品是非热解的，比天然可可脂更便宜。 它具有与天然可可脂相同的理想熔融性质。