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1.发明申请Methods of treating abnormal cell growth using c-MET and m-TOR inhibitors 审中-公开使用c-MET和m-TOR抑制剂治疗异常细胞生长的方法公开(公告)号：US20060035907A1
公开(公告)日：2006-02-16
申请号：US11063033
申请日：2005-02-22
申请人： James Christensen , Ravi Salgia
发明人： James Christensen , Ravi Salgia
IPC分类号： A61K39/395 , A61K31/496 , A61K31/495 , A61K31/4745
CPC分类号： C07K16/40 , A61K31/40 , A61K31/495 , A61K2039/505
摘要： The invention provides a method of treating abnormal cell growth in a mammal, such as a human, by administering to the mammal a therapeutically effective amount of a c-MET inhibitor and a mammalian target of rapamycin (mTOR) inhibitor.
摘要翻译： 本发明提供了通过向哺乳动物施用治疗有效量的c-MET抑制剂和哺乳动物雷帕霉素靶（mTOR）抑制剂来治疗哺乳动物例如人类异常细胞生长的方法。
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2.发明申请PAXILLIN MUTATIONS, METHODS OF ASSESSING RISK OF METASTASIS AND METHODS OF STAGING TUMORS 审中-公开PAXILLIN突变体，评估肿瘤风险的方法和分期肿瘤的方法公开(公告)号：US20100075320A1
公开(公告)日：2010-03-25
申请号：US12526870
申请日：2008-02-15
申请人： Ravi Salgia
发明人： Ravi Salgia
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156
摘要： Disclosed herein are methods for assessing risk of metastasis of a tumor in a mammal by determining the paxillin gene copy number per cell in the tumor or by detecting the presence of a paxillin mutation in the tumor. The presence of an increased paxillin gene copy number or a paxillin mutation is indicative of an increased risk of metastasis. Methods of staging tumors and methods of reducing invasiveness or metastasis of a cancer cell are also provided. Oligonucleotides comprising a paxillin mutation and antibodies capable of recognizing a paxillin mutant are disclosed.
摘要翻译： 本文公开了通过确定肿瘤中每个细胞的桩蛋白基因拷贝数或通过检测肿瘤中桩蛋白突变的存在来评估哺乳动物肿瘤转移的风险的方法。 增加的桩蛋白基因拷贝数或桩蛋白突变的存在表明转移的风险增加。 还提供了分期肿瘤的方法和降低癌细胞侵袭或转移的方法。 公开了包含桩蛋白突变的寡核苷酸和能识别桩蛋白突变体的抗体。
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公开(公告)号：US20130217012A1
公开(公告)日：2013-08-22
申请号：US13701569
申请日：2011-06-03
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/6893
摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. The invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-CBL.
摘要翻译： 本发明一般涉及分子生物学和生长因子调节领域。 本发明涉及可用于诊断和治疗与突变c-CBL相关的人类肺癌的方法和组合物。
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公开(公告)号：US20100062441A1
公开(公告)日：2010-03-11
申请号：US12530172
申请日：2008-03-14
申请人： Ravi Salgia
发明人： Ravi Salgia
CPC分类号： C12Q1/6886 , A61K31/00 , A61K49/0008 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/16
摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-Met.
摘要翻译： 本发明一般涉及分子生物学和生长因子调节领域。 更具体地，本发明涉及可用于诊断和治疗与突变c-Met相关的人类肺癌的方法和组合物。
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5.发明申请Methods and compositions for the identification, assessment, and therapy of small cell lung cancer 审中-公开用于小细胞肺癌鉴别，评估和治疗的方法和组合物公开(公告)号：US20050233991A1
公开(公告)日：2005-10-20
申请号：US10507549
申请日：2003-03-20
申请人： Ravi Salgia
发明人： Ravi Salgia
IPC分类号： A61K31/00 , A61K31/7088 , A61K38/00 , A61K38/54 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P35/04 , A61P43/00 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/574
CPC分类号： A61K38/005 , A61K31/00 , G01N33/5011 , G01N33/57423 , G01N2333/52 , G01N2333/715 , G01N2333/726 , G01N2333/82 , G01N2333/9121
摘要： The invention provides novel methods and compositions for modulating small cell lung cancer (SCLC) proliferation and metastasis through modulation of CXCR4 activity or expression. Also provided are methods for identifying compounds that modulate SCLC proliferation and metastasis through modulation of CXCR4 activity or expression. Further provided are methods for treating SCLC proliferation and metastasis, as well as methods for determining whether subjects are suitable candidates for treatment of SCLC via modulation of CXCR4 activity.
摘要翻译： 本发明提供了通过调节CXCR4活性或表达调节小细胞肺癌（SCLC）增殖和转移的新方法和组合物。 还提供了通过调节CXCR4活性或表达来鉴定调节SCLC增殖和转移的化合物的方法。 还提供了用于治疗SCLC增殖和转移的方法，以及用于确定受试者是否是通过调节CXCR4活性治疗SCLC的合适候选者的方法。
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