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5 条记录 (耗时 0.034 秒)

    FUSED HETEROCYCLES
    1.
    发明申请
    FUSED HETEROCYCLES 失效
    熔融杂环

    公开(公告)号：US20080004328A1

    公开(公告)日：2008-01-03

    申请号：US11833903

    申请日：2007-08-03

    申请人： James Dorsey ,  Michele Heffernan ,  Qun Fang ,  Robert Foglesong ,  Seth Hopkins ,  Cyprian Ogbu ,  Mustapha Soukri ,  Kerry Spear

    发明人： James Dorsey ,  Michele Heffernan ,  Qun Fang ,  Robert Foglesong ,  Seth Hopkins ,  Cyprian Ogbu ,  Mustapha Soukri ,  Kerry Spear

    IPC分类号： A61K31/407

    CPC分类号： A61K31/407 ,  C07D491/04 ,  C07D495/04

    摘要： This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.

    摘要翻译： 本发明提供具有下式的稠合杂环：其中R 1是选自H，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R 2是选自H取代或未取代的烯基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R 3是选自H，C 1 -C 6取代或未取代的烷基，取代或未取代的芳基烷基和取代的 或未取代的杂芳基烷基。 R 4是选自OH和O - O + X +的成员，其中X + +是正离子，其中 是选自有机正离子和无机阳离子的成员。 取代或未取代的芳基烷基和取代或未取代的杂芳基烷基部分具有下式：其中Ar是选自取代或未取代的芳基和取代或未取代的杂芳基的成员。 索引n是从1到4的整数。

    Beta-sheet mimetics and composition and methods relating thereto
    4.
    发明申请
    Beta-sheet mimetics and composition and methods relating thereto 审中-公开
    β-折叠模拟物及其组合和方法

    公开(公告)号：US20060084653A1

    公开(公告)日：2006-04-20

    申请号：US11295833

    申请日：2005-12-06

    申请人： Cyprian Ogbu ,  Hwa-Ok Kim ,  Mark Blaskovich

    发明人： Cyprian Ogbu ,  Hwa-Ok Kim ,  Mark Blaskovich

    IPC分类号： A61K31/503 ,  A61K31/4745 ,  A61K31/454 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C40B40/00

    摘要： Compounds having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein A, A′, B, X, Y, R2, R3, R4 and R5 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing such compounds, are tryptase antagonists.

    摘要翻译： 具有以下结构的化合物：包括其药学上可接受的盐和立体异构体，其中A，A'，B，X，Y，R 2，R 3， 4和R 5 5如本文所定义。 这些化合物在广泛的应用中具有应用价值，包括用作诊断和治疗剂。 特别地，本发明的化合物和含有这些化合物的药物组合物是类胰蛋白酶拮抗剂。