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    TREATMENT OF TISSUE DEFECTS WITH A THERAPEUTIC COMPOSITION
    1.
    发明申请
    TREATMENT OF TISSUE DEFECTS WITH A THERAPEUTIC COMPOSITION 审中-公开
    用治疗组合物治疗组织缺损

    公开(公告)号：US20080193424A1

    公开(公告)日：2008-08-14

    申请号：US12028361

    申请日：2008-02-08

    申请人： James M. McKale ,  Joel C. Higgins ,  Matthew Swift

    发明人： James M. McKale ,  Joel C. Higgins ,  Matthew Swift

    IPC分类号： A61K35/12

    CPC分类号： A61K35/16 ,  A61K35/35 ,  A61K2300/00

    摘要： Methods for treating a tissue defect include applying therapeutic compositions to the tissue defect. Treatment of a tissue defect, including wound healing can be enhanced by a process including obtaining blood compatible with the subject, fractionating the blood from the subject to produce a blood component, obtaining stromal cells from the subject, combining the stromal cells and the blood component to form a therapeutic composition, and delivering the therapeutic composition to the tissue defect. Therapeutic compositions for promoting wound healing include isolated stromal cells and a blood component.

    摘要翻译： 治疗组织缺损的方法包括将治疗组合物施用于组织缺损。 包括伤口愈合的组织缺损的治疗可以通过包括获得与受试者相容的血液，从受试者分离血液以产生血液成分，从受试者获得基质细胞，组合基质细胞和血液成分 以形成治疗组合物，并将治疗组合物递送至组织缺损。 用于促进伤口愈合的治疗组合物包括分离的基质细胞和血液成分。

    Apparatus and method for separating and concentrating fluids containing multiple components
    4.
    发明授权
    Apparatus and method for separating and concentrating fluids containing multiple components 有权
    用于分离和浓缩含有多种组分的流体的装置和方法

    公开(公告)号：US07845499B2

    公开(公告)日：2010-12-07

    申请号：US11441276

    申请日：2006-05-25

    申请人： Joel C. Higgins ,  Matthew Swift ,  Nathan Gordon ,  Barry F. Hecker

    发明人： Joel C. Higgins ,  Matthew Swift ,  Nathan Gordon ,  Barry F. Hecker

    IPC分类号： B01D21/26

    CPC分类号： B01D17/12 ,  B01D17/0217 ,  B01D21/262 ,  B01L3/50215 ,  B01L9/54 ,  B01L2200/026 ,  B01L2400/0409 ,  B01L2400/0478 ,  G01N33/491

    摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

    摘要翻译： 允许分离和收集一部分样品的装置。 该设备在与离心机一起使用时允许在设备中以各种分数的形式产生。 可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。 因此，各种馏分的分离可以基本上快速有效。 也可以将来自样品的选择的部分单独或作为混合物的一部分施用于患者。

    Apparatus and method for separating and concentrating fluids containing multiple components
    7.
    发明授权
    Apparatus and method for separating and concentrating fluids containing multiple components 有权
    用于分离和浓缩含有多种组分的流体的装置和方法

    公开(公告)号：US08062534B2

    公开(公告)日：2011-11-22

    申请号：US12961191

    申请日：2010-12-06

    申请人： Joel C. Higgins ,  Matthew Swift ,  Nathan Gordon ,  Barry F. Hecker

    发明人： Joel C. Higgins ,  Matthew Swift ,  Nathan Gordon ,  Barry F. Hecker

    IPC分类号： B04B5/02

    CPC分类号： B01D17/12 ,  B01D17/0217 ,  B01D21/262 ,  B01L3/50215 ,  B01L9/54 ,  B01L2200/026 ,  B01L2400/0409 ,  B01L2400/0478 ,  G01N33/491

    摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

    摘要翻译： 允许分离和收集一部分样品的装置。 该设备在与离心机一起使用时允许在设备中以各种分数的形式产生。 可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。 因此，各种馏分的分离可以基本上快速有效。 也可以将来自样品的选择的部分单独或作为混合物的一部分施用于患者。

    METHOD AND DEVICE FOR HERNIA REPAIR
    8.
    发明申请
    METHOD AND DEVICE FOR HERNIA REPAIR 审中-公开
    HERNIA修复的方法和装置

    公开(公告)号：US20090192528A1

    公开(公告)日：2009-07-30

    申请号：US12021739

    申请日：2008-01-29

    申请人： Joel C. Higgins ,  Matthew Swift

    发明人： Joel C. Higgins ,  Matthew Swift

    IPC分类号： A61B17/11 ,  A61F2/02

    CPC分类号： A61L27/3641 ,  A61L27/3608 ,  A61L27/3616 ,  A61L27/3804 ,  A61L31/005

    摘要： A device for repairing a hernia defect in a patient, the device having a biocompatible mesh material having a treated surface and a tissue composition coated on at least a portion of the treated surface, where the tissue composition originates from the patient. A method of preparing a surgical mesh for repairing a hernia defect, comprises placing a tissue specimen into a container, centrifuging the container to separate the specimen into at least two fractions, then drawing a selected fraction from the container, treating a surface of a biocompatible mesh and coating the surface-treated biocompatible mesh with the selected fraction.

    摘要翻译： 一种用于修复患者疝缺损的装置，所述装置具有生物相容的网状材料，其具有经处理的表面和组织组合物，所述组织组合物涂覆在经处理的表面的至少一部分上，其中所述组织组成来源于患者。 一种制备用于修复疝缺损的外科手术网的方法，包括将组织样本放入容器中，离心所述容器以将所述样本分离成至少两个部分，然后从所述容器中抽出选定的部分，处理生物相容性的表面 筛选并用选择的部分涂覆经表面处理的生物相容性筛网。

    Surgical Mesh Spray and Delivery System
    10.
    发明申请
    Surgical Mesh Spray and Delivery System 有权
    手术网喷雾和输送系统

    公开(公告)号：US20130040042A1

    公开(公告)日：2013-02-14

    申请号：US13206190

    申请日：2011-08-09

    申请人： Matthew Swift

    发明人： Matthew Swift

    IPC分类号： B05D5/00 ,  B05C5/00

    CPC分类号： A61F13/00991 ,  A61F2/0063 ,  B05B7/08 ,  B05B12/16

    摘要： A device for spraying a biological substance onto a biocompatible implant. The device includes a housing that defines a sterile chamber. A spray head is within the chamber and proximate to a first end. A first conduit is configured to direct the biological substance into the chamber through a first spray tip of the spray head. A second conduit is configured to direct an activator into the chamber through a second spray tip of the spray head. A third conduit is configured to direct compressed air to the chamber through a third spray tip of the spay head. The spray head is configured to direct a coating of the biological substance as activated by the activator to the implant seated within the chamber at a second end that is opposite to the first end.

    摘要翻译： 用于将生物物质喷洒到生物相容性植入物上的装置。 该装置包括限定无菌室的壳体。 喷雾头在腔室内并靠近第一端。 第一导管构造成通过喷头的第一喷嘴将生物物质引导到腔室中。 第二导管构造成通过喷头的第二喷嘴将活化剂引导到腔室中。 第三导管构造成通过喷头的第三喷嘴将压缩空气引导到腔室。 喷头被构造成将由激活剂激活的生物物质的涂层引导到位于腔室内的植入物处于与第一端相对的第二端。