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    System and Apparatus for Continuous Monitoring of Movement Disorders
    4.
    发明申请
    System and Apparatus for Continuous Monitoring of Movement Disorders 有权
    用于连续监测运动障碍的系统和装置

    公开(公告)号：US20100145236A1

    公开(公告)日：2010-06-10

    申请号：US12632778

    申请日：2009-12-07

    申请人： Andrew Greenberg ,  James McNames ,  Pedro Mateo Riobo Aboy

    发明人： Andrew Greenberg ,  James McNames ,  Pedro Mateo Riobo Aboy

    IPC分类号： A61B5/11

    CPC分类号： G04G21/025 ,  A61B5/0002 ,  A61B5/1101 ,  A61B5/1118 ,  A61B5/681 ,  A61B2560/029 ,  A61B2560/0456 ,  A61B2560/0475 ,  A61B2562/0219 ,  G01S5/0257 ,  G01S5/0294 ,  G01S19/42

    摘要： Disclosed embodiments include a complete system and platform which allows for continuous monitoring of movement disorders during normal daily activities in the clinic, home, and other normal daily environments. The system comprises: 1) a wearable apparatus for continuous monitoring of movement disorders, 2) a docking station, 3) a web server, and 4) methods for statistical analysis that generate movement impairment measures. Disclosed embodiments include a wearable movement monitoring apparatus comprising of (a) a sensor module including a plurality of low power micro-electromechanical systems kinematics sensors; (b) a microprocessor module including a low power microcontroller configured for device control, device status, and device communication; (c) a data storage module including a solid state local storage medium; (d) a wireless communication module including a low power surface mount transceiver and an integrated antenna; and (e) a power and docking module including a battery, an energy charging regulator circuit, and a docking connector.

    摘要翻译： 公开的实施例包括完整的系统和平台，其允许在诊所，家庭和其他正常日常环境中的正常日常活动期间连续监测运动障碍。 该系统包括：1）用于连续监测运动障碍的穿戴式装置，2）对接站，3）网络服务器，以及4）产生运动损伤测量的统计分析方法。 公开的实施例包括一种可穿戴运动监测装置，包括：（a）包括多个低功率微机电系统运动传感器的传感器模块; （b）微处理器模块，其包括被配置用于设备控制，设备状态和设备通信的低功率微控制器; （c）包括固态本地存储介质的数据存储模块; （d）包括低功率表面安装收发器和集成天线的无线通信模块; 和（e）包括电池，能量充电调节器电路和对接连接器的电力和​​对接模块。

    Method and apparatus for assessment of fluid responsiveness
    5.
    发明授权
    Method and apparatus for assessment of fluid responsiveness 有权
    评估液体反应性的方法和装置

    公开(公告)号：US08529458B2

    公开(公告)日：2013-09-10

    申请号：US12891795

    申请日：2010-09-27

    申请人： Sunghan Kim ,  Pedro Mateo Riobo Aboy ,  James McNames

    发明人： Sunghan Kim ,  Pedro Mateo Riobo Aboy ,  James McNames

    IPC分类号： A61B5/02

    CPC分类号： A61B5/0205 ,  A61B5/412 ,  A61B5/4848 ,  A61B2505/03

    摘要： Methods and apparatus for determining a cardiac parameter from cardiovascular pressure signals including arterial blood pressure (ABP) and the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration and predict fluid responsiveness are disclosed. Disclosed embodiments include a method for assessing fluid responsiveness implemented in a digital computer with one or more processors comprising: (a) measuring a cardiovascular signal, and (b) computing a dynamic index predictive of fluid responsiveness from said cardiovascular signal using a nonlinear state space estimator. According to one particular embodiment, and without limitation, the nonlinear state space estimator is based on a model for cardiovascular signals such as arterial blood pressure or plethysmogram signals, and employs a marginalized particle filter to estimate a dynamic index predictive of fluid responsiveness that is substantially equivalent to a variation in pulse pressure of said cardiovascular signal.

    摘要翻译： 公开了用于从心血管压力信号（包括动脉血压（ABP））和光电体积描记信号确定心脏参数的方法和装置，以量化由呼吸引起的幅度调制程度并预测流体反应性。 公开的实施例包括用于评估在具有一个或多个处理器的数字计算机中实现的流体响应性的方法，包括：（a）测量心血管信号，以及（b）使用非线性状态空间计算预测来自所述心血管信号的流体响应性的动态指数 估计。 根据一个特定实施例，非限制性地，非线性状态空间估计器基于诸如动脉血压或体积描记信号的心血管信号的模型，并且使用边缘化的粒子滤波器来估计预测流体响应性的动态指数，其基本上 相当于所述心血管信号的脉压的变化。

    METHOD AND APPARATUS FOR CONTINUOUS MEASUREMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND ESSENTIAL TREMOR WITH WEARABLE SENSORS
    6.
    发明申请
    METHOD AND APPARATUS FOR CONTINUOUS MEASUREMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND ESSENTIAL TREMOR WITH WEARABLE SENSORS 有权
    用于连续测量PARKINSON'S疾病和基本TREMOR与可靠传感器的运动症状的方法和装置

    公开(公告)号：US20100030119A1

    公开(公告)日：2010-02-04

    申请号：US12511038

    申请日：2009-07-28

    申请人： James McNames ,  Pedro Mateo Riobo Aboy ,  Andrew Greenberg

    发明人： James McNames ,  Pedro Mateo Riobo Aboy ,  Andrew Greenberg

    IPC分类号： A61B5/11

    CPC分类号： A61B5/1101 ,  A61B5/4082

    摘要： Disclosed embodiments include an apparatus for generating a plurality of movement impairment indices from one or more kinematic signals to characterize movement disorders. Additionally we disclose methods for generating a plurality of movement impairment indices from one or more kinematic signals obtained from one or more kinematic sensors, said methods implemented in a digital computer with one or more processors in order to characterize movement disorders based on spectral analysis, regularity metrics, and time-frequency analsysis.

    摘要翻译： 公开的实施例包括用于从一个或多个运动学信号产生多个运动损伤指数以表征运动障碍的装置。 另外，我们公开了从一个或多个运动学传感器获得的一个或多个运动学信号产生多个运动损伤指标的方法，所述方法在具有一个或多个处理器的数字计算机中实现，以便基于频谱分析来表征运动障碍，规律性 指标和时频分析。

    METHOD, SYSTEM, AND APPARATUS FOR CARDIOVASCULAR SIGNAL ANALYSIS, MODELING, AND MONITORING
    7.
    发明申请
    METHOD, SYSTEM, AND APPARATUS FOR CARDIOVASCULAR SIGNAL ANALYSIS, MODELING, AND MONITORING 有权
    心脏信号分析，建模与监测的方法，系统和装置

    公开(公告)号：US20090069647A1

    公开(公告)日：2009-03-12

    申请号：US12200995

    申请日：2008-08-29

    申请人： James McNames ,  Pedro Mateo Riobo Aboy

    发明人： James McNames ,  Pedro Mateo Riobo Aboy

    IPC分类号： A61B5/02

    CPC分类号： A61B5/0205 ,  A61B5/02405 ,  A61B5/031 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/412 ,  A61B5/725 ,  G06F19/00

    摘要： The present invention provides a method, system, and apparatus to monitor cardiovascular signals such as arterial blood pressure (ABP), pulse oximetry (POX), and intracranial pressure (ICP). The system can be used to calculate and monitor useful clinical information such as heart rate, respiratory rate, pulse pressure variation (PPV), harmonic phases, pulse morphology, and for artifact removal. The method uses a statistical state-space model of cardiovascular signals and a generalized Kalman filter (EKF) to simultaneously estimate and track the cardiovascular parameters of interest such as the cardiac fundamental frequency and higher harmonics, respiratory fundamental frequency and higher harmonics, cardiac component harmonic amplitudes and phases, respiratory component harmonic amplitudes and phases, and PPV.

    摘要翻译： 本发明提供一种监测心血管信号如血压（ABP），脉搏血氧饱和度（POX）和颅内压（ICP）的方法，系统和装置。 该系统可用于计算和监测有用的临床信息，如心率，呼吸频率，脉搏压力变化（PPV），谐波相位，脉冲形态和人为因素去除。 该方法使用心血管信号的统计状态空间模型和广义卡尔曼滤波器（EKF）来同时估计和跟踪感兴趣的心血管参数，例如心脏基频和高次谐波，呼吸基频和高次谐波，心脏分量谐波 振幅和相位，呼吸分量谐波幅度和相位以及PPV。

    Method and apparatus for continuous measurement of motor symptoms in parkinson's disease and essential tremor with wearable sensors
    8.
    发明授权
    Method and apparatus for continuous measurement of motor symptoms in parkinson's disease and essential tremor with wearable sensors 有权
    用于连续测量帕金森病运动症状和佩戴式传感器的基本震颤的方法和装置

    公开(公告)号：US09301712B2

    公开(公告)日：2016-04-05

    申请号：US12511038

    申请日：2009-07-28

    申请人： James McNames ,  Pedro Mateo Riobo Aboy ,  Andrew Greenberg

    发明人： James McNames ,  Pedro Mateo Riobo Aboy ,  Andrew Greenberg

    IPC分类号： A61B5/11 ,  A61B5/00

    CPC分类号： A61B5/1101 ,  A61B5/4082

    摘要： Disclosed embodiments include an apparatus for generating a plurality of movement impairment indices from one or more kinematic signals to characterize movement disorders. Additionally we disclose methods for generating a plurality of movement impairment indices from one or more kinematic signals obtained from one or more kinematic sensors, said methods implemented in a digital computer with one or more processors in order to characterize movement disorders based on spectral analysis, regularity metrics, and time-frequency analysis.

    摘要翻译： 公开的实施例包括用于从一个或多个运动学信号产生多个运动损伤指数以表征运动障碍的装置。 另外，我们公开了从一个或多个运动学传感器获得的一个或多个运动学信号产生多个运动损伤指标的方法，所述方法在具有一个或多个处理器的数字计算机中实现，以便基于频谱分析来表征运动障碍，规律性 指标和时频分析。