公开(公告)号：US20060247429A1

公开(公告)日：2006-11-02

申请号：US11358924

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigleman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigleman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060281175A1

公开(公告)日：2006-12-14

申请号：US11502876

申请日：2006-08-11

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： C12N5/06 ,  A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060217335A1

公开(公告)日：2006-09-28

申请号：US11358807

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/00 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060247428A1

公开(公告)日：2006-11-02

申请号：US11358540

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060217334A1

公开(公告)日：2006-09-28

申请号：US11358443

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07F9/02 ,  C07H21/00 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20070004663A1

公开(公告)日：2007-01-04

申请号：US11499520

申请日：2006-08-04

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060293271A1

公开(公告)日：2006-12-28

申请号：US11499521

申请日：2006-08-04

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060276635A1

公开(公告)日：2006-12-07

申请号：US11499828

申请日：2006-08-04

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis MacEjak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis MacEjak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： C07H21/02

CPC分类号： C12N15/111 ,  A61K9/0019 ,  A61K9/0048 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060217337A1

公开(公告)日：2006-09-28

申请号：US11358932

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060217336A1

公开(公告)日：2006-09-28

申请号：US11358863

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/00 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.