摘要:
The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula I or Formula II: in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method.
摘要:
The invention is related to modulation of Smad3 expression to prevent fibrosis and improve wound healing. Aspects of the invention, for example, include approaches to improve wound healing and/or reduce or prevent fibrosis by inhibiting Smad3. Embodiments described herein also include approaches to identify componds that modulate Smad3 expression and the preparation of pharmaceuticals comprising said compounds.
摘要:
The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.
摘要:
A support for wearing on the torso and supporting and raising a ceiling panel. The support includes a harness that engages the torso and a frame that is operatively connected to the harness and supports and raises the ceiling panel. The frame includes a pair of rods that extend upwardly and aligningly along the harness and an H-pipe that has a pair of uprights. Termination ends of the pair of rods extend snugly through lower restricted bores in the H-pipe. The frame further includes a pair of coil springs that are captured in the pair of uprights of the H-pipe and sit on the termination ends of the pair of rods. Upper ends of the uprights of the H-pipe contain ball sockets. The frame further includes a pair of balls that are rollingly received in the ball sockets in the H-pipe so as to form ball joints. The pair of balls have necks that extend freely through upper restricted bores in the H-pipe and supporting portions that diverge from the necks. The supporting portions of the pair of balls have rubber pads thereon that are flat and raise the ceiling panel and support the ceiling panel when the ceiling panel is against a ceiling and the pair of coil springs provide tension thereon.
摘要:
A catapult basketball includes a backboard having a basket affixed thereon, a rectangularly shaped board member having a court printed thereon, a ball member, a pair of die members for determining the point value of a shot, and a catapult shooting apparatus for propelling a ball member towards the basket.
摘要:
A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.
摘要:
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
摘要:
The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula (I) or Formula (II): in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method
摘要:
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
摘要:
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.