专利检索 ap:("James N. Wemple" OR "Gregory L. Karrick" OR "Floyd G. Spence") AND inv:"Gregory L. Karrick" 第 1 页

1.

发明授权
Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid 失效
标题翻译：合成3-氯-2,4,5-三氟苯甲酸的方法

公开(公告)号：US4885386A

公开(公告)日：1989-12-05

申请号：US264296

申请日：1988-10-28

申请人： James N. Wemple , Gregory L. Karrick , Floyd G. Spence

发明人： James N. Wemple , Gregory L. Karrick , Floyd G. Spence

IPC分类号： C07C51/363 , C07C63/70 , C07C227/08 , C07C227/18 , C07C229/60 , C07C229/62

CPC分类号： C07C227/08 , C07C51/363

摘要： An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a substituted amine to afford 3-amino-2,4,5-trifluorobenzoic acid followed by subsequent conversion of the amio intermediate into 3-chloro-2,4,5-trifluorobenzoic acid.